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The association of oxidant-antioxidant status in patients with chronic renal failure.
Ren Fail. 2016; 38(1):20-6.RF

Abstract

Oxidative stress has been linked to disease progression, including chronic renal failure (CRF). The aim of the present study was to determine malondialdehyde (MDA) as a sign of lipid peroxidation, and to investigate the association between antioxidant activities and three trace elements, in 49 patients with CRF. The erythrocyte and plasma trace elements [selenium (Se), zinc (Zn), and copper (Cu)] and antioxidant defense levels were determined: glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), vitamins E and C. The obtained values were compared with 42 age- and sex-matched healthy controls. There were significantly lower mean values of plasma Se, GPx, vitamins E and C, erythrocyte Se, SOD and CAT levels in the patient group compared to the control group (p < 0.001). Plasma MDA showed a significant increase in all CRF patients in comparison with controls. No significant difference was found in plasma Cu, Zn, and erythrocyte GPx, Cu and Zn levels between patient and control groups. These findings indicate oxidative stress is present in patients of CRF, and may serve to establish a simple protocol for evaluation of renal function.

Authors+Show Affiliations

a Pharmacology Department, Institute of Medical Technology , Almansur , Baghdad , Iraq .a Pharmacology Department, Institute of Medical Technology , Almansur , Baghdad , Iraq .b Health and Medical Technology College , Baghdad , Iraq .c Al-Nahrain Medical College , Baghdad , Iraq.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26524399

Citation

Aziz, Manal A., et al. "The Association of Oxidant-antioxidant Status in Patients With Chronic Renal Failure." Renal Failure, vol. 38, no. 1, 2016, pp. 20-6.
Aziz MA, Majeed GH, Diab KS, et al. The association of oxidant-antioxidant status in patients with chronic renal failure. Ren Fail. 2016;38(1):20-6.
Aziz, M. A., Majeed, G. H., Diab, K. S., & Al-Tamimi, R. J. (2016). The association of oxidant-antioxidant status in patients with chronic renal failure. Renal Failure, 38(1), 20-6. https://doi.org/10.3109/0886022X.2015.1103654
Aziz MA, et al. The Association of Oxidant-antioxidant Status in Patients With Chronic Renal Failure. Ren Fail. 2016;38(1):20-6. PubMed PMID: 26524399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of oxidant-antioxidant status in patients with chronic renal failure. AU - Aziz,Manal A, AU - Majeed,Ghanim H, AU - Diab,Kareem S, AU - Al-Tamimi,Raid J, Y1 - 2015/11/02/ PY - 2015/11/3/entrez PY - 2015/11/3/pubmed PY - 2017/1/11/medline KW - Antioxidants KW - chronic renal failure KW - lipid peroxidation KW - oxidative stress KW - trace elements SP - 20 EP - 6 JF - Renal failure JO - Ren Fail VL - 38 IS - 1 N2 - Oxidative stress has been linked to disease progression, including chronic renal failure (CRF). The aim of the present study was to determine malondialdehyde (MDA) as a sign of lipid peroxidation, and to investigate the association between antioxidant activities and three trace elements, in 49 patients with CRF. The erythrocyte and plasma trace elements [selenium (Se), zinc (Zn), and copper (Cu)] and antioxidant defense levels were determined: glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), vitamins E and C. The obtained values were compared with 42 age- and sex-matched healthy controls. There were significantly lower mean values of plasma Se, GPx, vitamins E and C, erythrocyte Se, SOD and CAT levels in the patient group compared to the control group (p < 0.001). Plasma MDA showed a significant increase in all CRF patients in comparison with controls. No significant difference was found in plasma Cu, Zn, and erythrocyte GPx, Cu and Zn levels between patient and control groups. These findings indicate oxidative stress is present in patients of CRF, and may serve to establish a simple protocol for evaluation of renal function. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/26524399/The_association_of_oxidant_antioxidant_status_in_patients_with_chronic_renal_failure_ L2 - https://www.tandfonline.com/doi/full/10.3109/0886022X.2015.1103654 DB - PRIME DP - Unbound Medicine ER -