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The Relationship between Galectin-3 and Different Patterns of Ventricular Geometry Remodelling in Aortic Valve Stenosis.
Heart Lung Circ 2016; 25(4):371-7HL

Abstract

BACKGROUND

This study was conducted to assess expression of Galectin-3 (Gal-3) in patients with different types of left ventricle (LV) hypertrophy geometry, and the relationship between Gal-3 expression and LV remodelling in patients with aortic valve stenosis (AS).

METHODS

Galectin-3 expression was measured in the plasma and myocardia of AS patients who underwent an aortic valve replacement procedure.

RESULTS

The study enrolled 77 consecutive patients with severe AS. Fifty-five (71.43%) of the enrolled patients had concentric hypertrophy (CH group), and had the highest degree of fibrosis (27.10±5.25%; p<0.001) and expression of Gal-3 in both plasma (19.11±2.06 ng/mL) and myocardial tissue (3.01±0.79). There was a strong positive correlation between the levels of fibrosis and Gal-3 expression in both plasma (r=0.584, p<0.001) and myocardium (r=0.522, p<0.001). Relative wall thickness (RWT) was strongly correlated with Gal-3 expression in both myocardium (r=0.594, p<0.001) and plasma (r=0.323, p=0.005). Additionally, N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were positively correlated with both fibrosis (r=0.313, p=0.036) and LV mass index (r=0.559, p<0.001).

CONCLUSIONS

Concentric hypertrophy geometry was the most common type of myocardium remodelling, and AS patients with CH geometry showed the highest levels of Gal-3 expression. Galectin-3 levels were positively correlated with fibrosis and RWT, both of which are crucial indicators of geometric remodelling. Galectin-3 and NT-proBNP levels may be valuable prognostic predictors in AS patients with myocardial remodelling.

Authors+Show Affiliations

The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China. Electronic address: mark090103@163.com.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26525848

Citation

Zhou, Kang, et al. "The Relationship Between Galectin-3 and Different Patterns of Ventricular Geometry Remodelling in Aortic Valve Stenosis." Heart, Lung & Circulation, vol. 25, no. 4, 2016, pp. 371-7.
Zhou K, Zhou Y, Zhao Y, et al. The Relationship between Galectin-3 and Different Patterns of Ventricular Geometry Remodelling in Aortic Valve Stenosis. Heart Lung Circ. 2016;25(4):371-7.
Zhou, K., Zhou, Y., Zhao, Y., Tan, C., Yuan, Z., Li, J., ... Zhou, X. (2016). The Relationship between Galectin-3 and Different Patterns of Ventricular Geometry Remodelling in Aortic Valve Stenosis. Heart, Lung & Circulation, 25(4), pp. 371-7. doi:10.1016/j.hlc.2015.08.021.
Zhou K, et al. The Relationship Between Galectin-3 and Different Patterns of Ventricular Geometry Remodelling in Aortic Valve Stenosis. Heart Lung Circ. 2016;25(4):371-7. PubMed PMID: 26525848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Relationship between Galectin-3 and Different Patterns of Ventricular Geometry Remodelling in Aortic Valve Stenosis. AU - Zhou,Kang, AU - Zhou,Yangzhao, AU - Zhao,Yuan, AU - Tan,Changming, AU - Yuan,Zhaoshun, AU - Li,Jianming, AU - Liao,Xiaobo, AU - Gu,Lu, AU - Zhou,Xinmin, Y1 - 2015/10/01/ PY - 2015/07/13/received PY - 2015/08/28/revised PY - 2015/08/31/accepted PY - 2015/11/4/entrez PY - 2015/11/4/pubmed PY - 2016/12/15/medline KW - Aortic stenosis KW - Fibrosis KW - Galectin-3 KW - Myocardial hypertrophy KW - Myocardial remodelling SP - 371 EP - 7 JF - Heart, lung & circulation JO - Heart Lung Circ VL - 25 IS - 4 N2 - BACKGROUND: This study was conducted to assess expression of Galectin-3 (Gal-3) in patients with different types of left ventricle (LV) hypertrophy geometry, and the relationship between Gal-3 expression and LV remodelling in patients with aortic valve stenosis (AS). METHODS: Galectin-3 expression was measured in the plasma and myocardia of AS patients who underwent an aortic valve replacement procedure. RESULTS: The study enrolled 77 consecutive patients with severe AS. Fifty-five (71.43%) of the enrolled patients had concentric hypertrophy (CH group), and had the highest degree of fibrosis (27.10±5.25%; p<0.001) and expression of Gal-3 in both plasma (19.11±2.06 ng/mL) and myocardial tissue (3.01±0.79). There was a strong positive correlation between the levels of fibrosis and Gal-3 expression in both plasma (r=0.584, p<0.001) and myocardium (r=0.522, p<0.001). Relative wall thickness (RWT) was strongly correlated with Gal-3 expression in both myocardium (r=0.594, p<0.001) and plasma (r=0.323, p=0.005). Additionally, N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were positively correlated with both fibrosis (r=0.313, p=0.036) and LV mass index (r=0.559, p<0.001). CONCLUSIONS: Concentric hypertrophy geometry was the most common type of myocardium remodelling, and AS patients with CH geometry showed the highest levels of Gal-3 expression. Galectin-3 levels were positively correlated with fibrosis and RWT, both of which are crucial indicators of geometric remodelling. Galectin-3 and NT-proBNP levels may be valuable prognostic predictors in AS patients with myocardial remodelling. SN - 1444-2892 UR - https://www.unboundmedicine.com/medline/citation/26525848/The_Relationship_between_Galectin_3_and_Different_Patterns_of_Ventricular_Geometry_Remodelling_in_Aortic_Valve_Stenosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1443-9506(15)01389-X DB - PRIME DP - Unbound Medicine ER -