Tags

Type your tag names separated by a space and hit enter

Iron Absorption from Two Milk Formulas Fortified with Iron Sulfate Stabilized with Maltodextrin and Citric Acid.
Nutrients. 2015 Oct 30; 7(11):8952-9.N

Abstract

BACKGROUND

Fortification of milk formulas with iron is a strategy widely used, but the absorption of non-heme iron is low. The purpose of this study was to measure the bioavailability of two iron fortified milk formulas designed to cover toddlers´ nutritional needs. These milks were fortified with iron sulfate stabilized with maltodextrin and citric acid.

METHODS

15 women (33-47 years old) participated in study. They received on different days, after an overnight fast, 200 mL of Formula A; 200 mL of Formula B; 30 mL of a solution of iron and ascorbic acid as reference dose and 200 mL of full fat cow's milk fortified with iron as ferrous sulfate. Milk formulas and reference dose were labeled with radioisotopes (59)Fe or (55)Fe, and the absorption of iron measured by erythrocyte incorporation of radioactive Fe.

RESULTS

The geometric mean iron absorption corrected to 40% of the reference dose was 20.6% for Formula A and 20.7% for Formula B, versus 7.5% of iron fortified cow's milk (p < 0.001). The post hoc Sheffé indeed differences between the milk formulas and the cow's milk (p < 0.001).

CONCLUSION

Formulas A and B contain highly bioavailable iron, which contributes to covering toddlers´ requirements of this micronutrient.

Authors+Show Affiliations

Micronutrients Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, Avda, El Líbano 5524, 6903625 Santiago, Chile. fpizarro@inta.uchile.cl.Micronutrients Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, Avda, El Líbano 5524, 6903625 Santiago, Chile. molivare@inta.uchile.cl.Kasdorf S.A. Av. Panamericana y Gral. Savio (1619) Garín, Buenos Aires, Argentina. eugemaciero@hotmail.com.Kasdorf S.A. Av. Panamericana y Gral. Savio (1619) Garín, Buenos Aires, Argentina. gustavo.krasnoff@danone.com.Kasdorf S.A. Av. Panamericana y Gral. Savio (1619) Garín, Buenos Aires, Argentina. nicolas.cocaro@danone.com.Escuela de Nutrición y Dietética-Universidad de Antioquia, UdeA, Calle 70 No. 52-21, Medellín, Colombia. diego.gaitan@udea.edu.co.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26529007

Citation

Pizarro, Fernando, et al. "Iron Absorption From Two Milk Formulas Fortified With Iron Sulfate Stabilized With Maltodextrin and Citric Acid." Nutrients, vol. 7, no. 11, 2015, pp. 8952-9.
Pizarro F, Olivares M, Maciero E, et al. Iron Absorption from Two Milk Formulas Fortified with Iron Sulfate Stabilized with Maltodextrin and Citric Acid. Nutrients. 2015;7(11):8952-9.
Pizarro, F., Olivares, M., Maciero, E., Krasnoff, G., Cócaro, N., & Gaitan, D. (2015). Iron Absorption from Two Milk Formulas Fortified with Iron Sulfate Stabilized with Maltodextrin and Citric Acid. Nutrients, 7(11), 8952-9. https://doi.org/10.3390/nu7115448
Pizarro F, et al. Iron Absorption From Two Milk Formulas Fortified With Iron Sulfate Stabilized With Maltodextrin and Citric Acid. Nutrients. 2015 Oct 30;7(11):8952-9. PubMed PMID: 26529007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron Absorption from Two Milk Formulas Fortified with Iron Sulfate Stabilized with Maltodextrin and Citric Acid. AU - Pizarro,Fernando, AU - Olivares,Manuel, AU - Maciero,Eugenia, AU - Krasnoff,Gustavo, AU - Cócaro,Nicolas, AU - Gaitan,Diego, Y1 - 2015/10/30/ PY - 2015/08/12/received PY - 2015/10/15/revised PY - 2015/10/19/accepted PY - 2015/11/4/entrez PY - 2015/11/4/pubmed PY - 2016/8/17/medline KW - iron bioavailability KW - iron fortification KW - milk formula KW - toddlers SP - 8952 EP - 9 JF - Nutrients JO - Nutrients VL - 7 IS - 11 N2 - BACKGROUND: Fortification of milk formulas with iron is a strategy widely used, but the absorption of non-heme iron is low. The purpose of this study was to measure the bioavailability of two iron fortified milk formulas designed to cover toddlers´ nutritional needs. These milks were fortified with iron sulfate stabilized with maltodextrin and citric acid. METHODS: 15 women (33-47 years old) participated in study. They received on different days, after an overnight fast, 200 mL of Formula A; 200 mL of Formula B; 30 mL of a solution of iron and ascorbic acid as reference dose and 200 mL of full fat cow's milk fortified with iron as ferrous sulfate. Milk formulas and reference dose were labeled with radioisotopes (59)Fe or (55)Fe, and the absorption of iron measured by erythrocyte incorporation of radioactive Fe. RESULTS: The geometric mean iron absorption corrected to 40% of the reference dose was 20.6% for Formula A and 20.7% for Formula B, versus 7.5% of iron fortified cow's milk (p < 0.001). The post hoc Sheffé indeed differences between the milk formulas and the cow's milk (p < 0.001). CONCLUSION: Formulas A and B contain highly bioavailable iron, which contributes to covering toddlers´ requirements of this micronutrient. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26529007/Iron_Absorption_from_Two_Milk_Formulas_Fortified_with_Iron_Sulfate_Stabilized_with_Maltodextrin_and_Citric_Acid_ L2 - https://www.mdpi.com/resolver?pii=nu7115448 DB - PRIME DP - Unbound Medicine ER -