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A male preponderance in patients with Indian post kala-azar dermal leishmaniasis is associated with increased circulating levels of testosterone.
Int J Dermatol. 2016 May; 55(5):e250-5.IJ

Abstract

BACKGROUND

Post kala-azar dermal leishmaniasis (PKDL) is a neglected parasitic disease that occurs after apparent cure from visceral leishmaniasis (VL) and poses a challenge for elimination of VL, being its proposed reservoir. Several epidemiological studies have proposed that sex hormones may account for the increased susceptibility of males towards infectious diseases, including leishmaniasis; however, the role of testosterone and sex bias, if any, in PKDL has not been evaluated.

METHODS

The study population included 87 patients with PKDL and 39 with VL; levels of testosterone were measured by competitive enzyme-linked immunosorbent assay along with their levels of antileishmanial immunoglobulin and IgG. The association of testosterone, if any, was then correlated with age, gender, humoral response, lesional profile, disease duration, and lag period.

RESULTS

A male predominance was evident in PKDL, not in VL; importantly, this male bias was predominant postpubertal, strongly indicative of an association between sex hormone and disease progression. Male patients with PKDL had significantly higher levels of testosterone, which regressed significantly with miltefosine, not with sodium antimony gluconate. Additionally, a significant correlation was found between plasma testosterone and antileishmanial IgG.

CONCLUSION

Taken together, our study has established a male dominance in PKDL, which showed a strong association with testosterone. This information should be taken into consideration for disease monitoring and control.

Authors+Show Affiliations

Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India.Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India.Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India.Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India.Department of Tropical Medicine, Calcutta School of Tropical Medicine, Kolkata, India.Department of Dermatology, Calcutta Medical College, Kolkata, India.Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26536363

Citation

Mukhopadhyay, Debanjan, et al. "A Male Preponderance in Patients With Indian Post Kala-azar Dermal Leishmaniasis Is Associated With Increased Circulating Levels of Testosterone." International Journal of Dermatology, vol. 55, no. 5, 2016, pp. e250-5.
Mukhopadhyay D, Mukherjee S, Ghosh S, et al. A male preponderance in patients with Indian post kala-azar dermal leishmaniasis is associated with increased circulating levels of testosterone. Int J Dermatol. 2016;55(5):e250-5.
Mukhopadhyay, D., Mukherjee, S., Ghosh, S., Roy, S., Saha, B., Das, N. K., & Chatterjee, M. (2016). A male preponderance in patients with Indian post kala-azar dermal leishmaniasis is associated with increased circulating levels of testosterone. International Journal of Dermatology, 55(5), e250-5. https://doi.org/10.1111/ijd.13048
Mukhopadhyay D, et al. A Male Preponderance in Patients With Indian Post Kala-azar Dermal Leishmaniasis Is Associated With Increased Circulating Levels of Testosterone. Int J Dermatol. 2016;55(5):e250-5. PubMed PMID: 26536363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A male preponderance in patients with Indian post kala-azar dermal leishmaniasis is associated with increased circulating levels of testosterone. AU - Mukhopadhyay,Debanjan, AU - Mukherjee,Shibabrata, AU - Ghosh,Susmita, AU - Roy,Susmita, AU - Saha,Bibhuti, AU - Das,Nilay Kanti, AU - Chatterjee,Mitali, Y1 - 2015/11/04/ PY - 2015/02/02/received PY - 2015/03/09/revised PY - 2015/04/01/accepted PY - 2015/11/5/entrez PY - 2015/11/5/pubmed PY - 2017/1/12/medline SP - e250 EP - 5 JF - International journal of dermatology JO - Int J Dermatol VL - 55 IS - 5 N2 - BACKGROUND: Post kala-azar dermal leishmaniasis (PKDL) is a neglected parasitic disease that occurs after apparent cure from visceral leishmaniasis (VL) and poses a challenge for elimination of VL, being its proposed reservoir. Several epidemiological studies have proposed that sex hormones may account for the increased susceptibility of males towards infectious diseases, including leishmaniasis; however, the role of testosterone and sex bias, if any, in PKDL has not been evaluated. METHODS: The study population included 87 patients with PKDL and 39 with VL; levels of testosterone were measured by competitive enzyme-linked immunosorbent assay along with their levels of antileishmanial immunoglobulin and IgG. The association of testosterone, if any, was then correlated with age, gender, humoral response, lesional profile, disease duration, and lag period. RESULTS: A male predominance was evident in PKDL, not in VL; importantly, this male bias was predominant postpubertal, strongly indicative of an association between sex hormone and disease progression. Male patients with PKDL had significantly higher levels of testosterone, which regressed significantly with miltefosine, not with sodium antimony gluconate. Additionally, a significant correlation was found between plasma testosterone and antileishmanial IgG. CONCLUSION: Taken together, our study has established a male dominance in PKDL, which showed a strong association with testosterone. This information should be taken into consideration for disease monitoring and control. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/26536363/A_male_preponderance_in_patients_with_Indian_post_kala_azar_dermal_leishmaniasis_is_associated_with_increased_circulating_levels_of_testosterone_ L2 - https://doi.org/10.1111/ijd.13048 DB - PRIME DP - Unbound Medicine ER -