Tags

Type your tag names separated by a space and hit enter

Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study.
Am J Clin Nutr 2015; 102(6):1490-7AJ

Abstract

BACKGROUND

Most previous prospective studies in Western countries found no association between consumption of fish and n-3 (ω-3) polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), for which the main source is fish, and pancreatic cancer risk. However, prospective evidence is still lacking among populations who have a relatively higher fish consumption.

OBJECTIVE

We investigated the association between fish and n-3 PUFA consumption and pancreatic cancer risk in a population-based, prospective study in Japanese men and women.

DESIGN

The Japan Public Health Center-based Prospective Study (JPHC study) has enrolled 140,420 subjects. We analyzed data on 82,024 eligible participants aged 45-74 y without a history of cancer who responded to a validated food-frequency questionnaire that included 138 items in 1995 for cohort I and in 1998 for cohort II. Participants were followed through 2010. HRs and corresponding 95% CIs for the highest compared with lowest quartile were calculated by using multivariable-adjusted Cox proportional hazards regression models.

RESULTS

During 1,068,774 person-years of follow-up, 449 newly diagnosed pancreatic cancers were identified. After the exclusion of pancreatic cancer cases in the first 3 y of follow-up, we found an inverse association of marine n-3 PUFA (EPA+DPA+DHA) and DHA consumption with pancreatic cancer risk: compared with the lowest quartile, multivariate-adjusted HRs in the highest quartile were 0.70 (95% CI: 0.51, 0.95; P-trend = 0.07) and 0.69 (0.51, 0.94; P-trend = 0.03), respectively. Associations for total fish, n-3 PUFA, EPA, and DPA consumption were similar but were not significant.

CONCLUSION

High n-3 PUFA, especially marine n-3 PUFAs, and DHA consumption was associated with a lower risk of pancreatic cancer in a population with a large variation in fish consumption, although the data apply to only a portion of the JPHC study subjects.

Authors+Show Affiliations

Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and tshimazu@ncc.go.jp.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26537936

Citation

Hidaka, Akihisa, et al. "Fish, N-3 PUFA Consumption, and Pancreatic Cancer Risk in Japanese: a Large, Population-based, Prospective Cohort Study." The American Journal of Clinical Nutrition, vol. 102, no. 6, 2015, pp. 1490-7.
Hidaka A, Shimazu T, Sawada N, et al. Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study. Am J Clin Nutr. 2015;102(6):1490-7.
Hidaka, A., Shimazu, T., Sawada, N., Yamaji, T., Iwasaki, M., Sasazuki, S., ... Tsugane, S. (2015). Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study. The American Journal of Clinical Nutrition, 102(6), pp. 1490-7. doi:10.3945/ajcn.115.113597.
Hidaka A, et al. Fish, N-3 PUFA Consumption, and Pancreatic Cancer Risk in Japanese: a Large, Population-based, Prospective Cohort Study. Am J Clin Nutr. 2015;102(6):1490-7. PubMed PMID: 26537936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study. AU - Hidaka,Akihisa, AU - Shimazu,Taichi, AU - Sawada,Norie, AU - Yamaji,Taiki, AU - Iwasaki,Motoki, AU - Sasazuki,Shizuka, AU - Inoue,Manami, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2015/11/04/ PY - 2015/04/22/received PY - 2015/09/16/accepted PY - 2015/11/6/entrez PY - 2015/11/6/pubmed PY - 2016/4/14/medline KW - Japanese KW - fish consumption KW - n–3 PUFAs KW - pancreatic cancer KW - prospective study SP - 1490 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 102 IS - 6 N2 - BACKGROUND: Most previous prospective studies in Western countries found no association between consumption of fish and n-3 (ω-3) polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), for which the main source is fish, and pancreatic cancer risk. However, prospective evidence is still lacking among populations who have a relatively higher fish consumption. OBJECTIVE: We investigated the association between fish and n-3 PUFA consumption and pancreatic cancer risk in a population-based, prospective study in Japanese men and women. DESIGN: The Japan Public Health Center-based Prospective Study (JPHC study) has enrolled 140,420 subjects. We analyzed data on 82,024 eligible participants aged 45-74 y without a history of cancer who responded to a validated food-frequency questionnaire that included 138 items in 1995 for cohort I and in 1998 for cohort II. Participants were followed through 2010. HRs and corresponding 95% CIs for the highest compared with lowest quartile were calculated by using multivariable-adjusted Cox proportional hazards regression models. RESULTS: During 1,068,774 person-years of follow-up, 449 newly diagnosed pancreatic cancers were identified. After the exclusion of pancreatic cancer cases in the first 3 y of follow-up, we found an inverse association of marine n-3 PUFA (EPA+DPA+DHA) and DHA consumption with pancreatic cancer risk: compared with the lowest quartile, multivariate-adjusted HRs in the highest quartile were 0.70 (95% CI: 0.51, 0.95; P-trend = 0.07) and 0.69 (0.51, 0.94; P-trend = 0.03), respectively. Associations for total fish, n-3 PUFA, EPA, and DPA consumption were similar but were not significant. CONCLUSION: High n-3 PUFA, especially marine n-3 PUFAs, and DHA consumption was associated with a lower risk of pancreatic cancer in a population with a large variation in fish consumption, although the data apply to only a portion of the JPHC study subjects. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26537936/Fish_n_3_PUFA_consumption_and_pancreatic_cancer_risk_in_Japanese:_a_large_population_based_prospective_cohort_study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.113597 DB - PRIME DP - Unbound Medicine ER -