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Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases.
Mediators Inflamm. 2015; 2015:620581.MI

Abstract

Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases (MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro)inflammation and might be involved in neurodegeneration. Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions. MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies. Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases. Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and multiple sclerosis (MS). We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.

Authors+Show Affiliations

Inflammation Research Center, VIB, 9052 Ghent, Belgium ; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium ; Department of Neurobiology, Institute for Biological Research, University of Belgrade, 11060 Belgrade, Serbia.Inflammation Research Center, VIB, 9052 Ghent, Belgium ; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium.Inflammation Research Center, VIB, 9052 Ghent, Belgium ; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium.Inflammation Research Center, VIB, 9052 Ghent, Belgium ; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26538832

Citation

Brkic, Marjana, et al. "Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases." Mediators of Inflammation, vol. 2015, 2015, p. 620581.
Brkic M, Balusu S, Libert C, et al. Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators Inflamm. 2015;2015:620581.
Brkic, M., Balusu, S., Libert, C., & Vandenbroucke, R. E. (2015). Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators of Inflammation, 2015, 620581. https://doi.org/10.1155/2015/620581
Brkic M, et al. Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators Inflamm. 2015;2015:620581. PubMed PMID: 26538832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. AU - Brkic,Marjana, AU - Balusu,Sriram, AU - Libert,Claude, AU - Vandenbroucke,Roosmarijn E, Y1 - 2015/10/11/ PY - 2015/07/13/received PY - 2015/09/03/revised PY - 2015/09/06/accepted PY - 2015/11/6/entrez PY - 2015/11/6/pubmed PY - 2016/8/16/medline SP - 620581 EP - 620581 JF - Mediators of inflammation JO - Mediators Inflamm. VL - 2015 N2 - Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases (MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro)inflammation and might be involved in neurodegeneration. Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions. MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies. Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases. Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and multiple sclerosis (MS). We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases. SN - 1466-1861 UR - https://www.unboundmedicine.com/medline/citation/26538832/Friends_or_Foes:_Matrix_Metalloproteinases_and_Their_Multifaceted_Roles_in_Neurodegenerative_Diseases_ L2 - https://dx.doi.org/10.1155/2015/620581 DB - PRIME DP - Unbound Medicine ER -