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One new 19-nor cucurbitane-type triterpenoid from the stems of Momordica charantia.
Nat Prod Res. 2016; 30(8):973-8.NP

Abstract

One new 19-nor cucurbitane-type triterpenoid (3β,9β,25-trihydroxy-7β-methoxy-19-nor-cucurbita-5,23(E)-diene) (1), together with other six known cucurbitane-type triterpenoids (2-7), were isolated from the stems of Momordica charantia L. The chemical structure of 1 was elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY and ROESY), MS experiments. Using MTT assay, compound 1 exhibited weak cytotoxicity against HL-60, A-549, and SK-BR-3 cell lines with the IC50 values at 27.3, 32.7 and 26.6 μM, respectively.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li YC
a Life school of Science and Technology , Henan Institute of Science and Technology , Xinxiang , China.
Xu XJ
a Life school of Science and Technology , Henan Institute of Science and Technology , Xinxiang , China.
Yang J
a Life school of Science and Technology , Henan Institute of Science and Technology , Xinxiang , China.
Wu XG
b School of Food Science , Henan Institute of Science and Technology , Xinxiang , China.
Fu QY
a Life school of Science and Technology , Henan Institute of Science and Technology , Xinxiang , China.

MeSH

Cell Line, TumorGlycosidesHumansMagnetic Resonance SpectroscopyMolecular StructureMomordica charantiaPlant ExtractsPlant StemsTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26539691

Citation

Li, Yong-chao, et al. "One New 19-nor Cucurbitane-type Triterpenoid From the Stems of Momordica Charantia." Natural Product Research, vol. 30, no. 8, 2016, pp. 973-8.
Li YC, Xu XJ, Yang J, et al. One new 19-nor cucurbitane-type triterpenoid from the stems of Momordica charantia. Nat Prod Res. 2016;30(8):973-8.
Li, Y. C., Xu, X. J., Yang, J., Wu, X. G., & Fu, Q. Y. (2016). One new 19-nor cucurbitane-type triterpenoid from the stems of Momordica charantia. Natural Product Research, 30(8), 973-8. https://doi.org/10.1080/14786419.2015.1089241
Li YC, et al. One New 19-nor Cucurbitane-type Triterpenoid From the Stems of Momordica Charantia. Nat Prod Res. 2016;30(8):973-8. PubMed PMID: 26539691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One new 19-nor cucurbitane-type triterpenoid from the stems of Momordica charantia. AU - Li,Yong-chao, AU - Xu,Xin-juan, AU - Yang,Jing, AU - Wu,Xing-gang, AU - Fu,Qing-yun, Y1 - 2015/11/05/ PY - 2015/11/6/entrez PY - 2015/11/6/pubmed PY - 2016/11/10/medline KW - 19-nor cucurbitane-type triterpenoid KW - Momordica charantia L KW - cytotoxicity SP - 973 EP - 8 JF - Natural product research JO - Nat Prod Res VL - 30 IS - 8 N2 - One new 19-nor cucurbitane-type triterpenoid (3β,9β,25-trihydroxy-7β-methoxy-19-nor-cucurbita-5,23(E)-diene) (1), together with other six known cucurbitane-type triterpenoids (2-7), were isolated from the stems of Momordica charantia L. The chemical structure of 1 was elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY and ROESY), MS experiments. Using MTT assay, compound 1 exhibited weak cytotoxicity against HL-60, A-549, and SK-BR-3 cell lines with the IC50 values at 27.3, 32.7 and 26.6 μM, respectively. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/26539691/One_new_19_nor_cucurbitane_type_triterpenoid_from_the_stems_of_Momordica_charantia_ DB - PRIME DP - Unbound Medicine ER -