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Penicyclones A-E, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp. F23-2.
J Nat Prod. 2015 Nov 25; 78(11):2699-703.JN

Abstract

Five new ambuic acid analogues, penicyclones A-E (1-5), were isolated from the extract of the deep-sea-derived fungus Penicillium sp. F23-2. The structures including the absolute configurations were established by interpretation of NMR and MS data, as well as the application of ECD, X-ray crystallography, and a chemical conversion, as well as the TDDFT-ECD calculations. Penicyclones A-E (1-5) exhibited antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus with MIC values ranging from 0.3 to 1.0 μg/mL.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Guo W
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
Zhang Z
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
Zhu T
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
Gu Q
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
Li D
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.

MeSH

Anti-Bacterial AgentsCrystallography, X-RayDoxorubicinDrug Screening Assays, AntitumorGram-Positive BacteriaHCT116 CellsHEK293 CellsHeLa CellsHumansMarine BiologyMicrobial Sensitivity TestsMolecular ConformationMolecular StructureNuclear Magnetic Resonance, BiomolecularPenicilliumPolyketidesStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26540093

Citation

Guo, Wenqiang, et al. "Penicyclones A-E, Antibacterial Polyketides From the Deep-Sea-Derived Fungus Penicillium Sp. F23-2." Journal of Natural Products, vol. 78, no. 11, 2015, pp. 2699-703.
Guo W, Zhang Z, Zhu T, et al. Penicyclones A-E, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp. F23-2. J Nat Prod. 2015;78(11):2699-703.
Guo, W., Zhang, Z., Zhu, T., Gu, Q., & Li, D. (2015). Penicyclones A-E, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp. F23-2. Journal of Natural Products, 78(11), 2699-703. https://doi.org/10.1021/acs.jnatprod.5b00655
Guo W, et al. Penicyclones A-E, Antibacterial Polyketides From the Deep-Sea-Derived Fungus Penicillium Sp. F23-2. J Nat Prod. 2015 Nov 25;78(11):2699-703. PubMed PMID: 26540093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Penicyclones A-E, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp. F23-2. AU - Guo,Wenqiang, AU - Zhang,Zhenzhen, AU - Zhu,Tianjiao, AU - Gu,Qianqun, AU - Li,Dehai, Y1 - 2015/11/05/ PY - 2015/11/6/entrez PY - 2015/11/6/pubmed PY - 2016/3/22/medline SP - 2699 EP - 703 JF - Journal of natural products JO - J Nat Prod VL - 78 IS - 11 N2 - Five new ambuic acid analogues, penicyclones A-E (1-5), were isolated from the extract of the deep-sea-derived fungus Penicillium sp. F23-2. The structures including the absolute configurations were established by interpretation of NMR and MS data, as well as the application of ECD, X-ray crystallography, and a chemical conversion, as well as the TDDFT-ECD calculations. Penicyclones A-E (1-5) exhibited antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus with MIC values ranging from 0.3 to 1.0 μg/mL. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/26540093/Penicyclones_A_E_Antibacterial_Polyketides_from_the_Deep_Sea_Derived_Fungus_Penicillium_sp__F23_2_ DB - PRIME DP - Unbound Medicine ER -