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From molecules in space to molecules in breath.
Paediatr Respir Rev. 2016 Jan; 17:50-2.PR

Abstract

The evolution of the selected ion flow tube, SIFT, used to study ion-molecule reactions of interstellar significance, to the selected ion flow tube mass spectrometry, SIFT-MS, analytical technique is described briefly. Focus is placed on the application of SIFT-MS to breath analysis and its potential for the detection of volatile biomarkers of disease including respiratory pathogens. Typical concentrations of particular volatile breath biomarkers are given and their associations with specific diseases are indicated. A special case is the identification and quantification of gaseous hydrogen cyanide that is elevated in the exhaled breath of patients with cystic fibrosis and is now taken as a biomarker of Pseudomonas aeruginosa infection of the airways.

Authors+Show Affiliations

Institute for Science and Technology in Medicine - Keele University, Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26541224

Citation

Smith, David. "From Molecules in Space to Molecules in Breath." Paediatric Respiratory Reviews, vol. 17, 2016, pp. 50-2.
Smith D. From molecules in space to molecules in breath. Paediatr Respir Rev. 2016;17:50-2.
Smith, D. (2016). From molecules in space to molecules in breath. Paediatric Respiratory Reviews, 17, 50-2. https://doi.org/10.1016/j.prrv.2015.08.012
Smith D. From Molecules in Space to Molecules in Breath. Paediatr Respir Rev. 2016;17:50-2. PubMed PMID: 26541224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From molecules in space to molecules in breath. A1 - Smith,David, Y1 - 2015/11/03/ PY - 2015/08/26/received PY - 2015/08/28/accepted PY - 2015/11/7/entrez PY - 2015/11/7/pubmed PY - 2017/1/18/medline SP - 50 EP - 2 JF - Paediatric respiratory reviews JO - Paediatr Respir Rev VL - 17 N2 - The evolution of the selected ion flow tube, SIFT, used to study ion-molecule reactions of interstellar significance, to the selected ion flow tube mass spectrometry, SIFT-MS, analytical technique is described briefly. Focus is placed on the application of SIFT-MS to breath analysis and its potential for the detection of volatile biomarkers of disease including respiratory pathogens. Typical concentrations of particular volatile breath biomarkers are given and their associations with specific diseases are indicated. A special case is the identification and quantification of gaseous hydrogen cyanide that is elevated in the exhaled breath of patients with cystic fibrosis and is now taken as a biomarker of Pseudomonas aeruginosa infection of the airways. SN - 1526-0550 UR - https://www.unboundmedicine.com/medline/citation/26541224/From_molecules_in_space_to_molecules_in_breath_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1526-0542(15)00083-4 DB - PRIME DP - Unbound Medicine ER -