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Impaired systemic vascular endothelial function in patients with non-arteritic anterior ischaemic optic neuropathy.
Graefes Arch Clin Exp Ophthalmol. 2016 May; 254(5):977-81.GA

Abstract

PURPOSE

The purpose of this study was to evaluate systemic endothelial function in elderly hypertension patients with non-arteritic anterior ischaemic optic neuropathy (NAION) by using a noninvasive physiological method: endothelium-dependent, flow-mediated vasodilation (FMD).

METHODS

Forty-two systemic hypertension patients with NAION (NAION group), 64 age- and sex-matched patients with systemic hypertension and no other ocular disease (hypertension group), and 100 age- and sex-matched healthy volunteers (normal group) were enrolled. FMD was evaluated using a high-resolution ultrasonography. Traditional cardiovascular risk factors and vascular parameters were measured.

RESULTS

Systolic blood pressure and diastolic blood pressure were significantly higher in patients with NAION compared with the control groups (p < 0.001). The FMD decreased significantly in the NAION group (6.02 ± 1.87 %) compared to in the hypertension group (7.86 ± 2.94 %, p < 0.001) and the normal group (8.99 ± 2.44 %, p < 0.001). By multivariable logistic regression analysis, FMD was significantly associated with NAION (OR, 1.79; 95%CI, 1.67-2.01).

CONCLUSIONS

NAION may be associated with systemic vascular endothelial dysfunction. FMD might be useful in the treatment monitoring of NAION.

Authors+Show Affiliations

Department of Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, 510080.Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, #58 Zhongshan Second Road, Guangzhou, Guangdong, China, 510080.Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, #58 Zhongshan Second Road, Guangzhou, Guangdong, China, 510080.Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, #58 Zhongshan Second Road, Guangzhou, Guangdong, China, 510080.Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, #58 Zhongshan Second Road, Guangzhou, Guangdong, China, 510080. dctzwh@139.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26542122

Citation

Yao, Fengjuan, et al. "Impaired Systemic Vascular Endothelial Function in Patients With Non-arteritic Anterior Ischaemic Optic Neuropathy." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 254, no. 5, 2016, pp. 977-81.
Yao F, Wan P, Su Y, et al. Impaired systemic vascular endothelial function in patients with non-arteritic anterior ischaemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2016;254(5):977-81.
Yao, F., Wan, P., Su, Y., Liao, R., & Zhu, W. (2016). Impaired systemic vascular endothelial function in patients with non-arteritic anterior ischaemic optic neuropathy. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 254(5), 977-81. https://doi.org/10.1007/s00417-015-3212-y
Yao F, et al. Impaired Systemic Vascular Endothelial Function in Patients With Non-arteritic Anterior Ischaemic Optic Neuropathy. Graefes Arch Clin Exp Ophthalmol. 2016;254(5):977-81. PubMed PMID: 26542122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired systemic vascular endothelial function in patients with non-arteritic anterior ischaemic optic neuropathy. AU - Yao,Fengjuan, AU - Wan,Pengxia, AU - Su,Yihua, AU - Liao,Ruiduan, AU - Zhu,Wenhui, Y1 - 2015/11/05/ PY - 2015/05/21/received PY - 2015/10/27/accepted PY - 2015/10/14/revised PY - 2015/11/7/entrez PY - 2015/11/7/pubmed PY - 2017/3/23/medline KW - Doppler sonography KW - Endothelial function KW - Nitric oxide KW - Non-arteritic anterior ischaemic optic neuropathy KW - Vasodilation SP - 977 EP - 81 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 254 IS - 5 N2 - PURPOSE: The purpose of this study was to evaluate systemic endothelial function in elderly hypertension patients with non-arteritic anterior ischaemic optic neuropathy (NAION) by using a noninvasive physiological method: endothelium-dependent, flow-mediated vasodilation (FMD). METHODS: Forty-two systemic hypertension patients with NAION (NAION group), 64 age- and sex-matched patients with systemic hypertension and no other ocular disease (hypertension group), and 100 age- and sex-matched healthy volunteers (normal group) were enrolled. FMD was evaluated using a high-resolution ultrasonography. Traditional cardiovascular risk factors and vascular parameters were measured. RESULTS: Systolic blood pressure and diastolic blood pressure were significantly higher in patients with NAION compared with the control groups (p < 0.001). The FMD decreased significantly in the NAION group (6.02 ± 1.87 %) compared to in the hypertension group (7.86 ± 2.94 %, p < 0.001) and the normal group (8.99 ± 2.44 %, p < 0.001). By multivariable logistic regression analysis, FMD was significantly associated with NAION (OR, 1.79; 95%CI, 1.67-2.01). CONCLUSIONS: NAION may be associated with systemic vascular endothelial dysfunction. FMD might be useful in the treatment monitoring of NAION. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/26542122/Impaired_systemic_vascular_endothelial_function_in_patients_with_non_arteritic_anterior_ischaemic_optic_neuropathy_ L2 - https://dx.doi.org/10.1007/s00417-015-3212-y DB - PRIME DP - Unbound Medicine ER -