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Biomineralization and biocompatibility studies of bone conductive scaffolds containing poly(3,4-ethylenedioxythiophene):poly(4-styrene sulfonate) (PEDOT:PSS).
J Mater Sci Mater Med 2015; 26(12):274JM

Abstract

Considering the well-known phenomenon of enhancing bone healing by applying electromagnetic stimulation, manufacturing conductive bone scaffolds is on demand to facilitate the delivery of electromagnetic stimulation to the injured region, which in turn significantly expedites the healing procedure in tissue engineering methods. For this purpose, hybrid conductive scaffolds composed of poly(3,4-ethylenedioxythiophene), poly(4-styrene sulfonate) (

PEDOT

PSS), gelatin (Gel), and bioactive glass (BaG) were produced employing freeze drying technique. Concentration of

PEDOT

PSS were optimized to design the most appropriate conductive scaffold in terms of biocompatibility and cell proliferation. More specifically, scaffolds with four different compositions of 0, 0.1, 0.3 and 0.6% (w/w)

PEDOT

PSS in the mixture of 10% (w/v) Gel and 30% (w/v) BaG were synthesized. Immersing the scaffolds in simulated body fluid (SBF), we evaluated the bioactivity of samples, and the biomineralization were studied in details using scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction analysis and Fourier transform infrared spectroscopy. By performing cytocompatibility analyses for 21 days using adult human mesenchymal stem cells, we concluded that the scaffolds with 0.3% (w/w)

PEDOT

PSS and conductivity of 170 μS/m has the optimized composition and further increasing the

PEDOT

PSS content has inverse effect on cell proliferation. Based on our finding, addition of this optimized amount of

PEDOT

PSS to our composition can increase the cell viability more than 4 times compared to a nonconductive composition.

Authors+Show Affiliations

Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK, 74106, USA. School of Chemical Engineering, Oklahoma State University, Stillwater, OK, 74078, USA.Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK, 74106, USA. BCAST, Institute of Materials and Manufacturing, Brunel University London, Uxbridge, London, UB8 3PH, UK. Brunel Institute for Bioengineering, Brunel University London, Uxbridge, London, UB8 3PH, UK.Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK, 74106, USA. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran.Electrical and Computer Engineering Department, North Carolina State University, Raleigh, NC, 27606, USA.Department of Biology, University of Central Oklahoma, Edmond, OK, 73034, USA.Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK, 74106, USA. lobat.tayebi@marquette.edu. Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Palo Alto, CA, 94305, USA. lobat.tayebi@marquette.edu. Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI, 53233, USA. lobat.tayebi@marquette.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26543020

Citation

Yazdimamaghani, Mostafa, et al. "Biomineralization and Biocompatibility Studies of Bone Conductive Scaffolds Containing Poly(3,4-ethylenedioxythiophene):poly(4-styrene Sulfonate) (PEDOT:PSS)." Journal of Materials Science. Materials in Medicine, vol. 26, no. 12, 2015, p. 274.
Yazdimamaghani M, Razavi M, Mozafari M, et al. Biomineralization and biocompatibility studies of bone conductive scaffolds containing poly(3,4-ethylenedioxythiophene):poly(4-styrene sulfonate) (PEDOT:PSS). J Mater Sci Mater Med. 2015;26(12):274.
Yazdimamaghani, M., Razavi, M., Mozafari, M., Vashaee, D., Kotturi, H., & Tayebi, L. (2015). Biomineralization and biocompatibility studies of bone conductive scaffolds containing poly(3,4-ethylenedioxythiophene):poly(4-styrene sulfonate) (PEDOT:PSS). Journal of Materials Science. Materials in Medicine, 26(12), p. 274. doi:10.1007/s10856-015-5599-8.
Yazdimamaghani M, et al. Biomineralization and Biocompatibility Studies of Bone Conductive Scaffolds Containing Poly(3,4-ethylenedioxythiophene):poly(4-styrene Sulfonate) (PEDOT:PSS). J Mater Sci Mater Med. 2015;26(12):274. PubMed PMID: 26543020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomineralization and biocompatibility studies of bone conductive scaffolds containing poly(3,4-ethylenedioxythiophene):poly(4-styrene sulfonate) (PEDOT:PSS). AU - Yazdimamaghani,Mostafa, AU - Razavi,Mehdi, AU - Mozafari,Masoud, AU - Vashaee,Daryoosh, AU - Kotturi,Hari, AU - Tayebi,Lobat, Y1 - 2015/11/05/ PY - 2015/07/09/received PY - 2015/10/03/accepted PY - 2015/11/7/entrez PY - 2015/11/7/pubmed PY - 2016/8/30/medline SP - 274 EP - 274 JF - Journal of materials science. Materials in medicine JO - J Mater Sci Mater Med VL - 26 IS - 12 N2 - UNLABELLED: Considering the well-known phenomenon of enhancing bone healing by applying electromagnetic stimulation, manufacturing conductive bone scaffolds is on demand to facilitate the delivery of electromagnetic stimulation to the injured region, which in turn significantly expedites the healing procedure in tissue engineering methods. For this purpose, hybrid conductive scaffolds composed of poly(3,4-ethylenedioxythiophene), poly(4-styrene sulfonate) ( PEDOT: PSS), gelatin (Gel), and bioactive glass (BaG) were produced employing freeze drying technique. Concentration of PEDOT: PSS were optimized to design the most appropriate conductive scaffold in terms of biocompatibility and cell proliferation. More specifically, scaffolds with four different compositions of 0, 0.1, 0.3 and 0.6% (w/w) PEDOT: PSS in the mixture of 10% (w/v) Gel and 30% (w/v) BaG were synthesized. Immersing the scaffolds in simulated body fluid (SBF), we evaluated the bioactivity of samples, and the biomineralization were studied in details using scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction analysis and Fourier transform infrared spectroscopy. By performing cytocompatibility analyses for 21 days using adult human mesenchymal stem cells, we concluded that the scaffolds with 0.3% (w/w) PEDOT: PSS and conductivity of 170 μS/m has the optimized composition and further increasing the PEDOT: PSS content has inverse effect on cell proliferation. Based on our finding, addition of this optimized amount of PEDOT: PSS to our composition can increase the cell viability more than 4 times compared to a nonconductive composition. SN - 1573-4838 UR - https://www.unboundmedicine.com/medline/citation/26543020/Biomineralization_and_biocompatibility_studies_of_bone_conductive_scaffolds_containing_poly_34_ethylenedioxythiophene_:poly_4_styrene_sulfonate___PEDOT:PSS__ L2 - https://doi.org/10.1007/s10856-015-5599-8 DB - PRIME DP - Unbound Medicine ER -