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Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans.
Age (Dordr) 2015; 37(6):113A

Abstract

Folic acid (FA) is an essential nutrient that the human body needs but cannot be synthesized on its own. Fortified foods and plant food sources such as green leafy vegetables, beans, fruits, and juices are good sources of FA to meet the daily requirements of the body. The aim was to evaluate the effect of dietary FA levels on the longevity of well-known experimental aging model Caenorhabditis elegans. Here, we show for first time that FA extends organism life span and causes a delay in aging. We observed that FA inhibits mechanistic target of rapamycin (mTOR) and insulin/insulin growth factor 1 (IGF-1) signaling pathways to control both oxidative stress levels and life span. The expression levels of stress- and life span-relevant gerontogenes, viz. daf-16, skn-1, and sir. 2.1, and oxidative enzymes, such as glutathione S-transferase 4 (GST-4) and superoxide dismutase 3 (SOD-3), were also found to be highly enhanced to attenuate the intracellular reactive oxygen species (ROS) damage and to delay the aging process. Our study promotes the use of FA to mitigate abiotic stresses and other aging-related ailments.

Authors+Show Affiliations

Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, 226015, India.Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, 226015, India.Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, 226015, India.Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, 226015, India.Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, 226015, India. r.pandeycimap@gmail.com.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26546011

Citation

Rathor, Laxmi, et al. "Folic Acid Supplementation at Lower Doses Increases Oxidative Stress Resistance and Longevity in Caenorhabditis Elegans." Age (Dordrecht, Netherlands), vol. 37, no. 6, 2015, p. 113.
Rathor L, Akhoon BA, Pandey S, et al. Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr). 2015;37(6):113.
Rathor, L., Akhoon, B. A., Pandey, S., Srivastava, S., & Pandey, R. (2015). Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordrecht, Netherlands), 37(6), p. 113. doi:10.1007/s11357-015-9850-5.
Rathor L, et al. Folic Acid Supplementation at Lower Doses Increases Oxidative Stress Resistance and Longevity in Caenorhabditis Elegans. Age (Dordr). 2015;37(6):113. PubMed PMID: 26546011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. AU - Rathor,Laxmi, AU - Akhoon,Bashir Akhlaq, AU - Pandey,Swapnil, AU - Srivastava,Swati, AU - Pandey,Rakesh, Y1 - 2015/11/06/ PY - 2015/05/29/received PY - 2015/10/23/accepted PY - 2015/11/8/entrez PY - 2015/11/8/pubmed PY - 2016/8/9/medline KW - Aging KW - Caenorhabditis elegans KW - Dietary restriction KW - Folic acid KW - Oxidative stress SP - 113 EP - 113 JF - Age (Dordrecht, Netherlands) JO - Age (Dordr) VL - 37 IS - 6 N2 - Folic acid (FA) is an essential nutrient that the human body needs but cannot be synthesized on its own. Fortified foods and plant food sources such as green leafy vegetables, beans, fruits, and juices are good sources of FA to meet the daily requirements of the body. The aim was to evaluate the effect of dietary FA levels on the longevity of well-known experimental aging model Caenorhabditis elegans. Here, we show for first time that FA extends organism life span and causes a delay in aging. We observed that FA inhibits mechanistic target of rapamycin (mTOR) and insulin/insulin growth factor 1 (IGF-1) signaling pathways to control both oxidative stress levels and life span. The expression levels of stress- and life span-relevant gerontogenes, viz. daf-16, skn-1, and sir. 2.1, and oxidative enzymes, such as glutathione S-transferase 4 (GST-4) and superoxide dismutase 3 (SOD-3), were also found to be highly enhanced to attenuate the intracellular reactive oxygen species (ROS) damage and to delay the aging process. Our study promotes the use of FA to mitigate abiotic stresses and other aging-related ailments. SN - 1574-4647 UR - https://www.unboundmedicine.com/medline/citation/26546011/Folic_acid_supplementation_at_lower_doses_increases_oxidative_stress_resistance_and_longevity_in_Caenorhabditis_elegans_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26546011/ DB - PRIME DP - Unbound Medicine ER -