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Zinc intake and risk of Crohn’s disease and ulcerative colitis: a prospective cohort study.
Int J Epidemiol 2015; 44(6):1995-2005IJ

Abstract

BACKGROUND

Diet plays a role in the pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC). Dietary zinc may influence risk of disease through effects on autophagy, innate and adaptive immune response and maintenance of the intestinal barrier.

METHODS

We analysed data from 170 776 women from the Nurses Health Study I and Nurses Health Study II, who were followed for 26 years. Zinc intake was assessed using semi-quantitative food frequency questionnaires administered every 4 years. Incident CD and UC were ascertained by medical record review. Cox proportional hazards models adjusting for potential confounders determined the independent association between zinc intake and incident disease.

RESULTS

Over 3 317 550 person-years (p-y) of follow-up, we identified 269 incident cases of CD and 338 incident cases of UC. Zinc intake ranged from 9 mg/day in the lowest quintile to 27 mg/day in the highest quintile. Compared with women with the lowest quintile of intake, the multivariate hazard ratios (HR) for CD were 0.92 [95% confidence interval (CI), 0.65 – 1.29) for women in the second quintile of intake, 0.60 (95% CI, 0.40 – 0.89) for the third quintile, 0.57 (95% CI, 0.38 – 0.86) for fourth quintile and 0.74 (95% CI, 0.50 – 1.10) for the highest quintile (Ptrend = 0.003). The association was stronger for dietary zinc (HR 0.63, 95% CI, 0.43 – 0.93, comparing extreme quintiles) than for zinc intake from supplements. Neither dietary nor supplemental zinc modified risk of UC.

CONCLUSIONS

In two large prospective cohorts of women, intake of zinc was inversely associated with risk of CD but not UC.

Authors+Show Affiliations

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. aananthakrishnan@mgh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26546032

Citation

Ananthakrishnan, Ashwin N., et al. "Zinc Intake and Risk of Crohn’s Disease and Ulcerative Colitis: a Prospective Cohort Study." International Journal of Epidemiology, vol. 44, no. 6, 2015, pp. 1995-2005.
Ananthakrishnan AN, Khalili H, Song M, et al. Zinc intake and risk of Crohn’s disease and ulcerative colitis: a prospective cohort study. Int J Epidemiol. 2015;44(6):1995-2005.
Ananthakrishnan, A. N., Khalili, H., Song, M., Higuchi, L. M., Richter, J. M., & Chan, A. T. (2015). Zinc intake and risk of Crohn’s disease and ulcerative colitis: a prospective cohort study. International Journal of Epidemiology, 44(6), pp. 1995-2005. doi:10.1093/ije/dyv301.
Ananthakrishnan AN, et al. Zinc Intake and Risk of Crohn’s Disease and Ulcerative Colitis: a Prospective Cohort Study. Int J Epidemiol. 2015;44(6):1995-2005. PubMed PMID: 26546032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc intake and risk of Crohn’s disease and ulcerative colitis: a prospective cohort study. AU - Ananthakrishnan,Ashwin N, AU - Khalili,Hamed, AU - Song,Mingyang, AU - Higuchi,Leslie M, AU - Richter,James M, AU - Chan,Andrew T, PY - 2015/11/8/entrez PY - 2015/11/8/pubmed PY - 2016/9/27/medline SP - 1995 EP - 2005 JF - International journal of epidemiology JO - Int J Epidemiol VL - 44 IS - 6 N2 - BACKGROUND: Diet plays a role in the pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC). Dietary zinc may influence risk of disease through effects on autophagy, innate and adaptive immune response and maintenance of the intestinal barrier. METHODS: We analysed data from 170 776 women from the Nurses Health Study I and Nurses Health Study II, who were followed for 26 years. Zinc intake was assessed using semi-quantitative food frequency questionnaires administered every 4 years. Incident CD and UC were ascertained by medical record review. Cox proportional hazards models adjusting for potential confounders determined the independent association between zinc intake and incident disease. RESULTS: Over 3 317 550 person-years (p-y) of follow-up, we identified 269 incident cases of CD and 338 incident cases of UC. Zinc intake ranged from 9 mg/day in the lowest quintile to 27 mg/day in the highest quintile. Compared with women with the lowest quintile of intake, the multivariate hazard ratios (HR) for CD were 0.92 [95% confidence interval (CI), 0.65 – 1.29) for women in the second quintile of intake, 0.60 (95% CI, 0.40 – 0.89) for the third quintile, 0.57 (95% CI, 0.38 – 0.86) for fourth quintile and 0.74 (95% CI, 0.50 – 1.10) for the highest quintile (Ptrend = 0.003). The association was stronger for dietary zinc (HR 0.63, 95% CI, 0.43 – 0.93, comparing extreme quintiles) than for zinc intake from supplements. Neither dietary nor supplemental zinc modified risk of UC. CONCLUSIONS: In two large prospective cohorts of women, intake of zinc was inversely associated with risk of CD but not UC. SN - 1464-3685 UR - https://www.unboundmedicine.com/medline/citation/26546032/Zinc_intake_and_risk_of_Crohn’s_disease_and_ulcerative_colitis:_a_prospective_cohort_study_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyv301 DB - PRIME DP - Unbound Medicine ER -