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Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology.

Abstract

Age-related dementia is increasingly recognized as having a mixed pathology, with contributions from both cerebrovascular factors and pathogenic factors associated with Alzheimer's disease (AD). Furthermore, there is accumulating evidence that vascular risk factors in midlife, e.g., obesity, diabetes, and hypertension, increase the risk of developing late-life dementia. Since obesity and changes in body weight/adiposity often drive diabetes and hypertension, understanding the relationship between adiposity and age-related dementia may reveal common underlying mechanisms. Here we offer a brief appraisal of how changes in body weight and adiposity are related to both AD and dementia on vascular basis, and examine the involvement of two key adipocyte-derived hormones: leptin and adiponectin. The evidence suggests that in midlife increased body weight/adiposity and subsequent changes in adipocyte-derived hormones may increase the long-term susceptibility to dementia. On the other hand, later in life, decreases in body weight/adiposity and related hormonal changes are early manifestations of disease that precede the onset of dementia and may promote AD and vascular pathology. Understanding the contribution of adiposity to age-related dementia may help identify the underlying pathological mechanisms common to both vascular dementia and AD, and provide new putative targets for early diagnosis and therapy. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia, edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

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    ,

    Feil Family Brain and Mind Research Institute, Joan and Sanford I. Weill Medical College of Cornell University, USA.

    Feil Family Brain and Mind Research Institute, Joan and Sanford I. Weill Medical College of Cornell University, USA. Electronic address: coi2001@med.cornell.edu.

    Source

    Biochimica et biophysica acta 1862:5 2016 05 pg 966-74

    MeSH

    Adipocytes
    Adiponectin
    Adipose Tissue
    Adiposity
    Age Factors
    Alzheimer Disease
    Animals
    Dementia, Vascular
    Humans
    Leptin

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26546479

    Citation

    Ishii, Makoto, and Costantino Iadecola. "Adipocyte-derived Factors in Age-related Dementia and Their Contribution to Vascular and Alzheimer Pathology." Biochimica Et Biophysica Acta, vol. 1862, no. 5, 2016, pp. 966-74.
    Ishii M, Iadecola C. Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology. Biochim Biophys Acta. 2016;1862(5):966-74.
    Ishii, M., & Iadecola, C. (2016). Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology. Biochimica Et Biophysica Acta, 1862(5), pp. 966-74. doi:10.1016/j.bbadis.2015.10.029.
    Ishii M, Iadecola C. Adipocyte-derived Factors in Age-related Dementia and Their Contribution to Vascular and Alzheimer Pathology. Biochim Biophys Acta. 2016;1862(5):966-74. PubMed PMID: 26546479.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology. AU - Ishii,Makoto, AU - Iadecola,Costantino, Y1 - 2015/11/09/ PY - 2015/08/24/received PY - 2015/10/29/revised PY - 2015/10/30/accepted PY - 2015/11/8/entrez PY - 2015/11/8/pubmed PY - 2019/1/25/medline KW - Adiponectin KW - Adiposity KW - Alzheimer's KW - Dementia KW - Leptin KW - Vascular SP - 966 EP - 74 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1862 IS - 5 N2 - Age-related dementia is increasingly recognized as having a mixed pathology, with contributions from both cerebrovascular factors and pathogenic factors associated with Alzheimer's disease (AD). Furthermore, there is accumulating evidence that vascular risk factors in midlife, e.g., obesity, diabetes, and hypertension, increase the risk of developing late-life dementia. Since obesity and changes in body weight/adiposity often drive diabetes and hypertension, understanding the relationship between adiposity and age-related dementia may reveal common underlying mechanisms. Here we offer a brief appraisal of how changes in body weight and adiposity are related to both AD and dementia on vascular basis, and examine the involvement of two key adipocyte-derived hormones: leptin and adiponectin. The evidence suggests that in midlife increased body weight/adiposity and subsequent changes in adipocyte-derived hormones may increase the long-term susceptibility to dementia. On the other hand, later in life, decreases in body weight/adiposity and related hormonal changes are early manifestations of disease that precede the onset of dementia and may promote AD and vascular pathology. Understanding the contribution of adiposity to age-related dementia may help identify the underlying pathological mechanisms common to both vascular dementia and AD, and provide new putative targets for early diagnosis and therapy. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia, edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/26546479/Adipocyte_derived_factors_in_age_related_dementia_and_their_contribution_to_vascular_and_Alzheimer_pathology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4439(15)00329-4 DB - PRIME DP - Unbound Medicine ER -