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Toxicological effects of bisphenol A on growth and antioxidant defense system in Oryza sativa as revealed by ultrastructure analysis.
Ecotoxicol Environ Saf. 2016 Feb; 124:277-284.EE

Abstract

The present study was conducted to evaluate the effect of bisphenol A (BPA) on rice seedlings grown in a hydroponic system. The obtained results demonstrated that at lower concentration (up to 10µM) BPA had some stimulatory effects on the growth of rice seedlings but at higher doses it significantly inhibited seedlings growth. The photosynthetic pigments were significantly decreased by high doses of BPA. Exposure to BPA caused increased membrane permeability in root cells and resulted in increased concentration of reactive oxygen species (ROS) and increased lipid peroxidation as revealed by thiobarbituric acid reactive substances (TBARS) assay. In leaves, superoxide dismutase (SOD) activity exhibited an increase at lower concentrations of BPA but was inhibited at the highest dose (200µM) of BPA. At 100µM of BPA, a significant increase in antioxidant activities in leaves was observed but at 200µM this activity was inhibited. In roots, a significant decrease in enzymes activity was recorded at the highest concentration of BPA (200µM); however, ascorbate peroxidase (APX) and catalase (CAT) activities were significantly increased at the concentrations of 10 and 50µM in comparison to the control. Moreover, the present results revealed that BPA severely affected cell organelles in rice seedlings. It can be concluded that the observed adverse effects in rice seedlings by BPA in the present study could be attributed to the oxidative stress caused by BPA.

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Authors+Show Affiliations

Zhejiang Key Lab of Crop Germplasm, Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310058, China; Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology (KUST) Kohat, Khyber Pakhtunkhwa 26000, Pakistan.

Zhejiang Key Lab of Crop Germplasm, Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310058, China.

Zhejiang Key Lab of Crop Germplasm, Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310058, China.

Zhejiang Key Lab of Crop Germplasm, Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310058, China.

Department of Botany, Kohat University of Science and Technology (KUST) Kohat, Khyber Pakhtunkhwa 26000, Pakistan.

Zhejiang Key Lab of Crop Germplasm, Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310058, China.

Zhejiang Key Lab of Crop Germplasm, Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310058, China.

Zhejiang Key Lab of Crop Germplasm, Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, 866 Yuhangtang Rd, Hangzhou 310058, China. Electronic address: ygan@zju.edu.cn.

MeSH

AntioxidantsAscorbate PeroxidasesBenzhydryl CompoundsCatalaseHydroponicsLipid PeroxidationMicroscopy, Electron, TransmissionOryzaOxidative StressPhenolsPhotosynthesisPlant LeavesPlant RootsReactive Oxygen SpeciesSeedlingsThiobarbituric Acid Reactive Substances

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26547398

Citation

Ali, Imran, et al. "Toxicological Effects of Bisphenol a On Growth and Antioxidant Defense System in Oryza Sativa as Revealed By Ultrastructure Analysis." Ecotoxicology and Environmental Safety, vol. 124, 2016, pp. 277-284.

Ali I, Liu B, Farooq MA, et al. Toxicological effects of bisphenol A on growth and antioxidant defense system in Oryza sativa as revealed by ultrastructure analysis. Ecotoxicol Environ Saf. 2016;124:277-284.

Ali, I., Liu, B., Farooq, M. A., Islam, F., Azizullah, A., Yu, C., Su, W., & Gan, Y. (2016). Toxicological effects of bisphenol A on growth and antioxidant defense system in Oryza sativa as revealed by ultrastructure analysis. Ecotoxicology and Environmental Safety, 124, 277-284. https://doi.org/10.1016/j.ecoenv.2015.10.027

Ali I, et al. Toxicological Effects of Bisphenol a On Growth and Antioxidant Defense System in Oryza Sativa as Revealed By Ultrastructure Analysis. Ecotoxicol Environ Saf. 2016;124:277-284. PubMed PMID: 26547398.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Toxicological effects of bisphenol A on growth and antioxidant defense system in Oryza sativa as revealed by ultrastructure analysis. AU - Ali,Imran, AU - Liu,Bohan, AU - Farooq,Muhammad Ahsan, AU - Islam,Faisal, AU - Azizullah,Azizullah, AU - Yu,Chunyan, AU - Su,Wen, AU - Gan,Yinbo, Y1 - 2015/11/11/ PY - 2015/03/13/received PY - 2015/10/17/revised PY - 2015/10/23/accepted PY - 2015/11/9/entrez PY - 2015/11/9/pubmed PY - 2016/8/12/medline KW - Antioxidant enzymes KW - Bisphenol A KW - Oxidative stress KW - Rice KW - Ultra-structure SP - 277 EP - 284 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 124 N2 - The present study was conducted to evaluate the effect of bisphenol A (BPA) on rice seedlings grown in a hydroponic system. The obtained results demonstrated that at lower concentration (up to 10µM) BPA had some stimulatory effects on the growth of rice seedlings but at higher doses it significantly inhibited seedlings growth. The photosynthetic pigments were significantly decreased by high doses of BPA. Exposure to BPA caused increased membrane permeability in root cells and resulted in increased concentration of reactive oxygen species (ROS) and increased lipid peroxidation as revealed by thiobarbituric acid reactive substances (TBARS) assay. In leaves, superoxide dismutase (SOD) activity exhibited an increase at lower concentrations of BPA but was inhibited at the highest dose (200µM) of BPA. At 100µM of BPA, a significant increase in antioxidant activities in leaves was observed but at 200µM this activity was inhibited. In roots, a significant decrease in enzymes activity was recorded at the highest concentration of BPA (200µM); however, ascorbate peroxidase (APX) and catalase (CAT) activities were significantly increased at the concentrations of 10 and 50µM in comparison to the control. Moreover, the present results revealed that BPA severely affected cell organelles in rice seedlings. It can be concluded that the observed adverse effects in rice seedlings by BPA in the present study could be attributed to the oxidative stress caused by BPA. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/26547398/Toxicological_effects_of_bisphenol_A_on_growth_and_antioxidant_defense_system_in_Oryza_sativa_as_revealed_by_ultrastructure_analysis_ DB - PRIME DP - Unbound Medicine ER -