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The role of lymphocytes in the development and treatment of alopecia areata.
Expert Rev Clin Immunol. 2015; 11(12):1335-51.ER

Abstract

Alopecia areata (AA) development is associated with both innate and adaptive immune cell activation, migration to peri- and intra-follicular regions, and hair follicle disruption. Both CD4(+) and CD8(+) lymphocytes are abundant in AA lesions; however, CD8(+) cytotoxic T lymphocytes are more likely to enter inside hair follicles, circumstantially suggesting that they have a significant role to play in AA development. Several rodent models recapitulate important features of the human autoimmune disease and demonstrate that CD8(+) cytotoxic T lymphocytes are fundamentally required for AA induction and perpetuation. However, the initiating events, the self-antigens involved, and the molecular signaling pathways, all need further exploration. Studying CD8(+) cytotoxic T lymphocytes and their fate decisions in AA development may reveal new and improved treatment approaches.

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Authors+Show Affiliations

Guo H
a 1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada. b 2 Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
Cheng Y
a 1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.
Shapiro J
a 1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada. c 3 Department of Dermatology, New York University, Langone Medical Center, New York, USA.
McElwee K
a 1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada. d 4 Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.

MeSH

Alopecia AreataAutoantigensAutoimmune DiseasesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansSignal Transduction

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26548356

Citation

Guo, Hongwei, et al. "The Role of Lymphocytes in the Development and Treatment of Alopecia Areata." Expert Review of Clinical Immunology, vol. 11, no. 12, 2015, pp. 1335-51.
Guo H, Cheng Y, Shapiro J, et al. The role of lymphocytes in the development and treatment of alopecia areata. Expert Rev Clin Immunol. 2015;11(12):1335-51.
Guo, H., Cheng, Y., Shapiro, J., & McElwee, K. (2015). The role of lymphocytes in the development and treatment of alopecia areata. Expert Review of Clinical Immunology, 11(12), 1335-51. https://doi.org/10.1586/1744666X.2015.1085306
Guo H, et al. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata. Expert Rev Clin Immunol. 2015;11(12):1335-51. PubMed PMID: 26548356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of lymphocytes in the development and treatment of alopecia areata. AU - Guo,Hongwei, AU - Cheng,Yabin, AU - Shapiro,Jerry, AU - McElwee,Kevin, Y1 - 2015/09/07/ PY - 2015/11/10/entrez PY - 2015/11/10/pubmed PY - 2016/8/20/medline KW - alopecia areata KW - autoimmune inflammation KW - hair follicles KW - lymphocytes KW - pathogenesis KW - treatment SP - 1335 EP - 51 JF - Expert review of clinical immunology JO - Expert Rev Clin Immunol VL - 11 IS - 12 N2 - Alopecia areata (AA) development is associated with both innate and adaptive immune cell activation, migration to peri- and intra-follicular regions, and hair follicle disruption. Both CD4(+) and CD8(+) lymphocytes are abundant in AA lesions; however, CD8(+) cytotoxic T lymphocytes are more likely to enter inside hair follicles, circumstantially suggesting that they have a significant role to play in AA development. Several rodent models recapitulate important features of the human autoimmune disease and demonstrate that CD8(+) cytotoxic T lymphocytes are fundamentally required for AA induction and perpetuation. However, the initiating events, the self-antigens involved, and the molecular signaling pathways, all need further exploration. Studying CD8(+) cytotoxic T lymphocytes and their fate decisions in AA development may reveal new and improved treatment approaches. SN - 1744-8409 UR - https://www.unboundmedicine.com/medline/citation/26548356/The_role_of_lymphocytes_in_the_development_and_treatment_of_alopecia_areata_ DB - PRIME DP - Unbound Medicine ER -