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Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan.
Allergy 2016; 71(3):421-5A

Abstract

Recent studies revealed that Amblyomma or Ixodes tick bites may cause red meat allergy, in which galactose-α-1,3-galactose (α-Gal) is a major IgE-binding epitope. The incidence of red meat allergy is high in Shimane Prefecture, as is tick-transmitted Japanese spotted fever. Therefore, we speculated that tick bites may cause these meat allergies. The carbohydrate α-Gal was detected in the salivary gland protein of Haemaphysalis longicornis (H. longicornis), the vector for Japanese spotted fever, by immunoblotting using anti-α-Gal antibody. H. longicornis salivary gland protein-specific IgE was detected in the sera of 24 of 30 patients with red meat allergies. Sensitization to tick salivary gland protein containing α-Gal is possibly a major etiology of red meat allergy; the carbohydrate plays a crucial role in its allergenicity. These results further indicate that the α-Gal epitope is present not only in Amblyomma or Ixodes, but also in Haemaphysalis.

Authors+Show Affiliations

Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan.Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan.Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan.Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan.Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26551325

Citation

Chinuki, Y, et al. "Haemaphysalis Longicornis Tick Bites Are a Possible Cause of Red Meat Allergy in Japan." Allergy, vol. 71, no. 3, 2016, pp. 421-5.
Chinuki Y, Ishiwata K, Yamaji K, et al. Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan. Allergy. 2016;71(3):421-5.
Chinuki, Y., Ishiwata, K., Yamaji, K., Takahashi, H., & Morita, E. (2016). Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan. Allergy, 71(3), pp. 421-5. doi:10.1111/all.12804.
Chinuki Y, et al. Haemaphysalis Longicornis Tick Bites Are a Possible Cause of Red Meat Allergy in Japan. Allergy. 2016;71(3):421-5. PubMed PMID: 26551325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan. AU - Chinuki,Y, AU - Ishiwata,K, AU - Yamaji,K, AU - Takahashi,H, AU - Morita,E, Y1 - 2015/12/29/ PY - 2015/10/29/accepted PY - 2015/11/10/entrez PY - 2015/11/10/pubmed PY - 2016/11/5/medline KW - Galactose-α-1,3-galactose (α-Gal) KW - Haemaphysalis longicornis KW - Japanese spotted fever KW - red meat allergy KW - salivary gland SP - 421 EP - 5 JF - Allergy JO - Allergy VL - 71 IS - 3 N2 - Recent studies revealed that Amblyomma or Ixodes tick bites may cause red meat allergy, in which galactose-α-1,3-galactose (α-Gal) is a major IgE-binding epitope. The incidence of red meat allergy is high in Shimane Prefecture, as is tick-transmitted Japanese spotted fever. Therefore, we speculated that tick bites may cause these meat allergies. The carbohydrate α-Gal was detected in the salivary gland protein of Haemaphysalis longicornis (H. longicornis), the vector for Japanese spotted fever, by immunoblotting using anti-α-Gal antibody. H. longicornis salivary gland protein-specific IgE was detected in the sera of 24 of 30 patients with red meat allergies. Sensitization to tick salivary gland protein containing α-Gal is possibly a major etiology of red meat allergy; the carbohydrate plays a crucial role in its allergenicity. These results further indicate that the α-Gal epitope is present not only in Amblyomma or Ixodes, but also in Haemaphysalis. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/26551325/Haemaphysalis_longicornis_tick_bites_are_a_possible_cause_of_red_meat_allergy_in_Japan_ L2 - https://doi.org/10.1111/all.12804 DB - PRIME DP - Unbound Medicine ER -