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Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan.

Abstract

Recent studies revealed that Amblyomma or Ixodes tick bites may cause red meat allergy, in which galactose-α-1,3-galactose (α-Gal) is a major IgE-binding epitope. The incidence of red meat allergy is high in Shimane Prefecture, as is tick-transmitted Japanese spotted fever. Therefore, we speculated that tick bites may cause these meat allergies. The carbohydrate α-Gal was detected in the salivary gland protein of Haemaphysalis longicornis (H. longicornis), the vector for Japanese spotted fever, by immunoblotting using anti-α-Gal antibody. H. longicornis salivary gland protein-specific IgE was detected in the sera of 24 of 30 patients with red meat allergies. Sensitization to tick salivary gland protein containing α-Gal is possibly a major etiology of red meat allergy; the carbohydrate plays a crucial role in its allergenicity. These results further indicate that the α-Gal epitope is present not only in Amblyomma or Ixodes, but also in Haemaphysalis.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan.

    ,

    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan.

    ,

    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan.

    ,

    Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan.

    Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan.

    Source

    Allergy 71:3 2016 Mar pg 421-5

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Allergens
    Animals
    Female
    Food Hypersensitivity
    Galactose
    Geography
    Humans
    Immunoglobulin E
    Ixodes
    Japan
    Male
    Middle Aged
    Red Meat
    Tick Bites

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26551325

    Citation

    TY - JOUR T1 - Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan. AU - Chinuki,Y, AU - Ishiwata,K, AU - Yamaji,K, AU - Takahashi,H, AU - Morita,E, Y1 - 2015/12/29/ PY - 2015/10/29/accepted PY - 2015/11/10/entrez PY - 2015/11/10/pubmed PY - 2016/11/5/medline KW - Galactose-α-1,3-galactose (α-Gal) KW - Haemaphysalis longicornis KW - Japanese spotted fever KW - red meat allergy KW - salivary gland SP - 421 EP - 5 JF - Allergy JO - Allergy VL - 71 IS - 3 N2 - Recent studies revealed that Amblyomma or Ixodes tick bites may cause red meat allergy, in which galactose-α-1,3-galactose (α-Gal) is a major IgE-binding epitope. The incidence of red meat allergy is high in Shimane Prefecture, as is tick-transmitted Japanese spotted fever. Therefore, we speculated that tick bites may cause these meat allergies. The carbohydrate α-Gal was detected in the salivary gland protein of Haemaphysalis longicornis (H. longicornis), the vector for Japanese spotted fever, by immunoblotting using anti-α-Gal antibody. H. longicornis salivary gland protein-specific IgE was detected in the sera of 24 of 30 patients with red meat allergies. Sensitization to tick salivary gland protein containing α-Gal is possibly a major etiology of red meat allergy; the carbohydrate plays a crucial role in its allergenicity. These results further indicate that the α-Gal epitope is present not only in Amblyomma or Ixodes, but also in Haemaphysalis. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/26551325/Haemaphysalis_longicornis_tick_bites_are_a_possible_cause_of_red_meat_allergy_in_Japan_ L2 - https://doi.org/10.1111/all.12804 ER -