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Sevoflurane aggregates cognitive dysfunction and hippocampal oxidative stress induced by β-amyloid in rats.
Life Sci. 2015 Dec 15; 143:194-201.LS

Abstract

AIMS

To investigate the effects of sevoflurane inhalation on β-amyloid (Aβ)-induced cognitive disorders and hippocampal oxidative stress in rat models.

MATERIALS AND METHODS

Cognitive dysfunction is induced by hippocampal injection of Aβ1-40 (10μg in 2μl) for 22days. To explore the effect of sevoflurane inhalation on Aβ1-40 induced cognitive disorder, two doses of sevoflurane inhalation are used: 1.3% (Aβ+S1) and 2.6% (Aβ+S2). Sham operation (Sham, for operation control), saline injection (Control, for injection control) and 30% oxygen inhalation after Aβ1-40 injection (Aβ+O2, for inhalation control) were used as controls. All rats were further tested in electrical Y-maze and Morris water maze. Serum S100β levels, hippocampal superoxide dismutase (SOD) activity, S100β expression and malonyldialdehyde (MDA) concentrations were further quantified.

KEY FINDINGS

Rats in Aβ+O2, Aβ+S1 and Aβ+S2 groups had lower number of correct actions in the electrical Y maze task, longer escape latencies, less time exploring the original platform, elevated serum S100β levels, depressed hippocampal SOD activity, S100β expression and higher MDA concentrations compared to control group (p<0.05). Such difference was not significant between Aβ+S1 and Aβ+O2 rats. Rats in Aβ+S2 group, however, showed significantly impaired performances compared to those in Aβ+S1 group (p<0.05).

SIGNIFICANCE

Sevoflurane (2.6%) can aggravate the Aβ-induced cognitive dysfunction, possibly via the intracerebral oxidative stress response.

Authors+Show Affiliations

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang 110004, China.Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address: zhaop@sj-hospital.org.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26551432

Citation

Yue, Tian, et al. "Sevoflurane Aggregates Cognitive Dysfunction and Hippocampal Oxidative Stress Induced By Β-amyloid in Rats." Life Sciences, vol. 143, 2015, pp. 194-201.
Yue T, Shanbin G, Ling M, et al. Sevoflurane aggregates cognitive dysfunction and hippocampal oxidative stress induced by β-amyloid in rats. Life Sci. 2015;143:194-201.
Yue, T., Shanbin, G., Ling, M., Yuan, W., Ying, X., & Ping, Z. (2015). Sevoflurane aggregates cognitive dysfunction and hippocampal oxidative stress induced by β-amyloid in rats. Life Sciences, 143, 194-201. https://doi.org/10.1016/j.lfs.2015.11.002
Yue T, et al. Sevoflurane Aggregates Cognitive Dysfunction and Hippocampal Oxidative Stress Induced By Β-amyloid in Rats. Life Sci. 2015 Dec 15;143:194-201. PubMed PMID: 26551432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sevoflurane aggregates cognitive dysfunction and hippocampal oxidative stress induced by β-amyloid in rats. AU - Yue,Tian, AU - Shanbin,Guo, AU - Ling,Ma, AU - Yuan,Wang, AU - Ying,Xu, AU - Ping,Zhao, Y1 - 2015/11/06/ PY - 2015/03/12/received PY - 2015/10/09/revised PY - 2015/11/03/accepted PY - 2015/11/10/entrez PY - 2015/11/10/pubmed PY - 2016/4/9/medline KW - Amyloid protein KW - Cognitive dysfunctions KW - Oxidative stress KW - Sevoflurane inhalation SP - 194 EP - 201 JF - Life sciences JO - Life Sci. VL - 143 N2 - AIMS: To investigate the effects of sevoflurane inhalation on β-amyloid (Aβ)-induced cognitive disorders and hippocampal oxidative stress in rat models. MATERIALS AND METHODS: Cognitive dysfunction is induced by hippocampal injection of Aβ1-40 (10μg in 2μl) for 22days. To explore the effect of sevoflurane inhalation on Aβ1-40 induced cognitive disorder, two doses of sevoflurane inhalation are used: 1.3% (Aβ+S1) and 2.6% (Aβ+S2). Sham operation (Sham, for operation control), saline injection (Control, for injection control) and 30% oxygen inhalation after Aβ1-40 injection (Aβ+O2, for inhalation control) were used as controls. All rats were further tested in electrical Y-maze and Morris water maze. Serum S100β levels, hippocampal superoxide dismutase (SOD) activity, S100β expression and malonyldialdehyde (MDA) concentrations were further quantified. KEY FINDINGS: Rats in Aβ+O2, Aβ+S1 and Aβ+S2 groups had lower number of correct actions in the electrical Y maze task, longer escape latencies, less time exploring the original platform, elevated serum S100β levels, depressed hippocampal SOD activity, S100β expression and higher MDA concentrations compared to control group (p<0.05). Such difference was not significant between Aβ+S1 and Aβ+O2 rats. Rats in Aβ+S2 group, however, showed significantly impaired performances compared to those in Aβ+S1 group (p<0.05). SIGNIFICANCE: Sevoflurane (2.6%) can aggravate the Aβ-induced cognitive dysfunction, possibly via the intracerebral oxidative stress response. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/26551432/Sevoflurane_aggregates_cognitive_dysfunction_and_hippocampal_oxidative_stress_induced_by_β_amyloid_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(15)30066-7 DB - PRIME DP - Unbound Medicine ER -