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Rolipram-induced improvement of cognitive function correlates with changes in hippocampal CREB phosphorylation, BDNF and Arc protein levels.
Neurosci Lett. 2016 Jan 01; 610:171-6.NL

Abstract

Diabetics suffer from a higher risk of cognitive decline. cAMP response element-binding protein (CREB) is a transcription factor associated with memory and synaptic plasticity. Here, we investigated the molecular changes in the hippocampus correlated with diabetes associated cognitive decline (DACD) from a CREB-centered perspective in a rat model of type 2 diabetes. Furthermore, we tested the therapeutic effect of rolipram on DACD. High-fat diet and low-dose streptozocin were adopted to induce diabetes in SD rats. Results show that supplementation with rolipram for 23 days (0.5mg/kg, once a day) improved the performance of diabetic rats in Morris water navigation task with increased level of CREB, brain-derived neurotrophic factor (BDNF), and Arc protein in the hippocampus. Rolipram, acting as an inhibitor of PDE4, was found to repair the imbalance in the CREB/BDNF/Arc pathway. This study may provide important insights into the mechanisms underlying DACD and provide new therapeutic targets for clinical treatment.

Authors+Show Affiliations

Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's Hospital, 600 Yi Shan Road, Shanghai 200233, China.Department of Boxi medical center, The First Affiliated Hospital of Soochow University, No. 188 Shizi St, Suzhou, Jiangsu 215006, China.Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's Hospital, 600 Yi Shan Road, Shanghai 200233, China.Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's Hospital, 600 Yi Shan Road, Shanghai 200233, China.Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's Hospital, 600 Yi Shan Road, Shanghai 200233, China.Department of Geriatrics, Shanghai Jiao Tong University affiliated Sixth People's Hospital, 600 Yi Shan Road, Shanghai 200233, China. Electronic address: nning-my@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26552011

Citation

Zhong, Yuan, et al. "Rolipram-induced Improvement of Cognitive Function Correlates With Changes in Hippocampal CREB Phosphorylation, BDNF and Arc Protein Levels." Neuroscience Letters, vol. 610, 2016, pp. 171-6.
Zhong Y, Zhu Y, He T, et al. Rolipram-induced improvement of cognitive function correlates with changes in hippocampal CREB phosphorylation, BDNF and Arc protein levels. Neurosci Lett. 2016;610:171-6.
Zhong, Y., Zhu, Y., He, T., Li, W., Yan, H., & Miao, Y. (2016). Rolipram-induced improvement of cognitive function correlates with changes in hippocampal CREB phosphorylation, BDNF and Arc protein levels. Neuroscience Letters, 610, 171-6. https://doi.org/10.1016/j.neulet.2015.09.023
Zhong Y, et al. Rolipram-induced Improvement of Cognitive Function Correlates With Changes in Hippocampal CREB Phosphorylation, BDNF and Arc Protein Levels. Neurosci Lett. 2016 Jan 1;610:171-6. PubMed PMID: 26552011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rolipram-induced improvement of cognitive function correlates with changes in hippocampal CREB phosphorylation, BDNF and Arc protein levels. AU - Zhong,Yuan, AU - Zhu,Yitong, AU - He,Ting, AU - Li,Wei, AU - Yan,Hong, AU - Miao,Ya, Y1 - 2015/11/10/ PY - 2015/05/06/received PY - 2015/09/09/revised PY - 2015/09/21/accepted PY - 2015/11/10/entrez PY - 2015/11/10/pubmed PY - 2016/5/10/medline KW - Arc protein KW - Brain-derived neurotrophic factor KW - Cognition KW - Rolipram KW - cAMP response element-binding protein SP - 171 EP - 6 JF - Neuroscience letters JO - Neurosci Lett VL - 610 N2 - Diabetics suffer from a higher risk of cognitive decline. cAMP response element-binding protein (CREB) is a transcription factor associated with memory and synaptic plasticity. Here, we investigated the molecular changes in the hippocampus correlated with diabetes associated cognitive decline (DACD) from a CREB-centered perspective in a rat model of type 2 diabetes. Furthermore, we tested the therapeutic effect of rolipram on DACD. High-fat diet and low-dose streptozocin were adopted to induce diabetes in SD rats. Results show that supplementation with rolipram for 23 days (0.5mg/kg, once a day) improved the performance of diabetic rats in Morris water navigation task with increased level of CREB, brain-derived neurotrophic factor (BDNF), and Arc protein in the hippocampus. Rolipram, acting as an inhibitor of PDE4, was found to repair the imbalance in the CREB/BDNF/Arc pathway. This study may provide important insights into the mechanisms underlying DACD and provide new therapeutic targets for clinical treatment. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/26552011/Rolipram_induced_improvement_of_cognitive_function_correlates_with_changes_in_hippocampal_CREB_phosphorylation_BDNF_and_Arc_protein_levels_ DB - PRIME DP - Unbound Medicine ER -