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Susceptibility of Clostridium difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators.
Antimicrob Agents Chemother. 2016 01; 60(1):689-92.AA

Abstract

We determined the in vitro activity of SMT19969 and 11 comparators, including metronidazole, vancomycin, and fidaxomicin, against 107 C. difficile isolates of different antimicrobial resistance phenotypes. Fidaxomicin and SMT19969 were the most active. The fidaxomicin and SMT19969 geometric mean MICs were highest in ribotypes known to show multiple resistance. Coresistance to linezolid and moxifloxacin was evident in ribotypes 001, 017, 027, and 356. The high-level ceftriaxone resistance in ribotypes 356 and 018 was location linked.

Authors+Show Affiliations

Microbiology, Leeds Teaching Hospitals Trust, University of Leeds, Leeds, United Kingdom Healthcare Associated Infections Research Group, Leeds Institute for Biomedical and Clinical Sciences, University of Leeds, Leeds, United Kingdom.Healthcare Associated Infections Research Group, Leeds Institute for Biomedical and Clinical Sciences, University of Leeds, Leeds, United Kingdom.Summit Therapeutics, Abingdon, Oxfordshire, United Kingdom.Microbiology, Leeds Teaching Hospitals Trust, University of Leeds, Leeds, United Kingdom Healthcare Associated Infections Research Group, Leeds Institute for Biomedical and Clinical Sciences, University of Leeds, Leeds, United Kingdom mark.wilcox@nhs.net.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26552981

Citation

Freeman, Jane, et al. "Susceptibility of Clostridium Difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators." Antimicrobial Agents and Chemotherapy, vol. 60, no. 1, 2016, pp. 689-92.
Freeman J, Vernon J, Vickers R, et al. Susceptibility of Clostridium difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators. Antimicrob Agents Chemother. 2016;60(1):689-92.
Freeman, J., Vernon, J., Vickers, R., & Wilcox, M. H. (2016). Susceptibility of Clostridium difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators. Antimicrobial Agents and Chemotherapy, 60(1), 689-92. https://doi.org/10.1128/AAC.02000-15
Freeman J, et al. Susceptibility of Clostridium Difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators. Antimicrob Agents Chemother. 2016;60(1):689-92. PubMed PMID: 26552981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility of Clostridium difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators. AU - Freeman,Jane, AU - Vernon,Jonathan, AU - Vickers,Richard, AU - Wilcox,Mark H, Y1 - 2015/11/09/ PY - 2015/08/19/received PY - 2015/11/04/accepted PY - 2015/11/11/entrez PY - 2015/11/11/pubmed PY - 2016/9/30/medline SP - 689 EP - 92 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 60 IS - 1 N2 - We determined the in vitro activity of SMT19969 and 11 comparators, including metronidazole, vancomycin, and fidaxomicin, against 107 C. difficile isolates of different antimicrobial resistance phenotypes. Fidaxomicin and SMT19969 were the most active. The fidaxomicin and SMT19969 geometric mean MICs were highest in ribotypes known to show multiple resistance. Coresistance to linezolid and moxifloxacin was evident in ribotypes 001, 017, 027, and 356. The high-level ceftriaxone resistance in ribotypes 356 and 018 was location linked. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/26552981/Susceptibility_of_Clostridium_difficile_Isolates_of_Varying_Antimicrobial_Resistance_Phenotypes_to_SMT19969_and_11_Comparators_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=26552981 DB - PRIME DP - Unbound Medicine ER -