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[Alcohol consumption and epithelial cancer risk in the EPIC-Italy cohort].
Epidemiol Prev 2015 Sep-Dec; 39(5-6):345-9EP

Abstract

OBJECTIVES

to evaluate the association between baseline and lifetime alcohol consumption and the risk of epithelial cancer (all types) in the Italian cohort of the European Prospective Investigation into Cancer and nutrition (EPIC) study.

DESIGN

prospective study carried out in a large Italian population.

SETTING AND PARTICIPANTS

detailed information on the consumption of alcoholic beverages at baseline and over lifetime collected at enrolment into the EPIC study (1993-1998) by standardised questionnaires for 44,477 healthy adults.

MAIN OUTCOMES MEASURES

2,640 incident epithelial cancers identified during a mean follow-up of 11.4 years. Multivariate Cox proportional hazard models adjusted for several potential confounders were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (CI).

RESULTS

lifetime alcohol consumption (p for trend =0.005) was associated with epithelial cancer risk in the whole cohort. This effect was more evident in women (p =0.049) and in current smokers (p =0.012). Alcohol consumption at baseline was associated with the epithelial cancer risk in women (p for trend =0.01) and current smokers (p for trend =0.02). A significant interaction between alcohol consumption and smoke duration (p =0.015 for baseline; p =0.006 for lifetime) was identified.

CONCLUSIONS

in this large Italian population, alcohol consumption, particularly lifetime, is a significant risk factor for the development of epithelial cancers. This effect appears to be modulated by smoking habits.

Authors+Show Affiliations

SC epidemiologia molecolare e nutrizionale, Istituto per lo studio e prevenzione oncologica (ISPO), Firenze.SC epidemiologia molecolare e nutrizionale, Istituto per lo studio e prevenzione oncologica (ISPO), Firenze.SC epidemiologia molecolare e nutrizionale, Istituto per lo studio e prevenzione oncologica (ISPO), Firenze.Human Genetics Foundation (HuGeF), Torino. Unità di epidemiologia dei tumori, Città della salute e della scienza, Azienda ospedaliero-universitaria e Centro per la prevenzione oncologica (CPO) del Piemonte, Torino.Unità di epidemiologia dei tumori, Città della salute e della scienza, Azienda ospedaliero-universitaria e Centro per la prevenzione oncologica (CPO) del Piemonte, Torino.SC di epidemiologia e prevenzione, Fondazione IRCCS - Istituto nazionale dei tumori, Milano.SC di epidemiologia e prevenzione, Fondazione IRCCS - Istituto nazionale dei tumori, Milano.Dipartimento di medicina clinica e chirurgia, Università Federico II, Napoli.Dipartimento di medicina clinica e chirurgia, Università Federico II, Napoli.Registro dei tumori, Dipartimento di prevenzione medica, Azienda sanitaria provinciale (ASP) Ragusa.Registro dei tumori, Dipartimento di prevenzione medica, Azienda sanitaria provinciale (ASP) Ragusa.SC epidemiologia molecolare e nutrizionale, Istituto per lo studio e prevenzione oncologica (ISPO), Firenze. g.masala@ispo.toscana.it.

Pub Type(s)

Journal Article
Multicenter Study

Language

ita

PubMed ID

26554685

Citation

Saieva, Calogero, et al. "[Alcohol Consumption and Epithelial Cancer Risk in the EPIC-Italy Cohort]." Epidemiologia E Prevenzione, vol. 39, no. 5-6, 2015, pp. 345-9.
Saieva C, Caini S, Ceroti M, et al. [Alcohol consumption and epithelial cancer risk in the EPIC-Italy cohort]. Epidemiol Prev. 2015;39(5-6):345-9.
Saieva, C., Caini, S., Ceroti, M., Fasanelli, F., Ricceri, F., Agnoli, C., ... Masala, G. (2015). [Alcohol consumption and epithelial cancer risk in the EPIC-Italy cohort]. Epidemiologia E Prevenzione, 39(5-6), pp. 345-9.
Saieva C, et al. [Alcohol Consumption and Epithelial Cancer Risk in the EPIC-Italy Cohort]. Epidemiol Prev. 2015;39(5-6):345-9. PubMed PMID: 26554685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Alcohol consumption and epithelial cancer risk in the EPIC-Italy cohort]. AU - Saieva,Calogero, AU - Caini,Saverio, AU - Ceroti,Marco, AU - Fasanelli,Francesca, AU - Ricceri,Fulvio, AU - Agnoli,Claudia, AU - Grioni,Sara, AU - Mattiello,Amalia, AU - Santucci de Magistris,Maria, AU - Tumino,Rosario, AU - Martorana,Caterina, AU - Masala,Giovanna, PY - 2015/11/12/entrez PY - 2015/11/12/pubmed PY - 2017/6/24/medline SP - 345 EP - 9 JF - Epidemiologia e prevenzione JO - Epidemiol Prev VL - 39 IS - 5-6 N2 - OBJECTIVES: to evaluate the association between baseline and lifetime alcohol consumption and the risk of epithelial cancer (all types) in the Italian cohort of the European Prospective Investigation into Cancer and nutrition (EPIC) study. DESIGN: prospective study carried out in a large Italian population. SETTING AND PARTICIPANTS: detailed information on the consumption of alcoholic beverages at baseline and over lifetime collected at enrolment into the EPIC study (1993-1998) by standardised questionnaires for 44,477 healthy adults. MAIN OUTCOMES MEASURES: 2,640 incident epithelial cancers identified during a mean follow-up of 11.4 years. Multivariate Cox proportional hazard models adjusted for several potential confounders were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (CI). RESULTS: lifetime alcohol consumption (p for trend =0.005) was associated with epithelial cancer risk in the whole cohort. This effect was more evident in women (p =0.049) and in current smokers (p =0.012). Alcohol consumption at baseline was associated with the epithelial cancer risk in women (p for trend =0.01) and current smokers (p for trend =0.02). A significant interaction between alcohol consumption and smoke duration (p =0.015 for baseline; p =0.006 for lifetime) was identified. CONCLUSIONS: in this large Italian population, alcohol consumption, particularly lifetime, is a significant risk factor for the development of epithelial cancers. This effect appears to be modulated by smoking habits. SN - 1120-9763 UR - https://www.unboundmedicine.com/medline/citation/26554685/[Alcohol_consumption_and_epithelial_cancer_risk_in_the_EPIC_Italy_cohort]_ L2 - http://www.epiprev.it/node/3007 DB - PRIME DP - Unbound Medicine ER -