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Visit-to-Visit Glucose Variability Predicts the Development of End-Stage Renal Disease in Type 2 Diabetes: 10-Year Follow-Up of Taiwan Diabetes Study.
Medicine (Baltimore). 2015 Nov; 94(44):e1804.M

Abstract

The purpose of this study was to examine the association of glucose variability using coefficient of variation of fasting plasma glucose (FPG-CV) and coefficient of variation of glycated hemoglobin (HbA1c-CV) to end-stage renal disease (ESRD) in 31,841 Chinese patients with type 2 diabetes.Patients with type 2 diabetes enrolled in National Diabetes Care Management Program, aged ≧30 years, and free of ESRD (n = 31,841) in January 1, 2002 to December 31, 2004 were included. Extended Cox proportional hazards regression models with competing risk of all-cause mortality were used to evaluate risk factors on ESRD incidence. Patients were followed till 2012.After a median follow-up period of 8.23 years, 1642 patients developed ESRD, giving a crude incidence rate of 6.27/1000 person-years (6.36 for men, 6.19 for women). After the multivariate adjustment, both FPG-CV and HbA1c-CV were independent predictors of ESRD with corresponding hazard ratios of 1.20 (95% confidence interval [CI] 1.01, 1.41), 1.24 (95% CI 1.05, 1.46) in HbA1c-CV from fourth to fifth quintile and 1.23 (95% CI 1.03, 1.47) in FPG-CV from fifth quintile.One-year visit-to-visit glucose variability expressed by FPG-CV and HbA1c-CV predicted development of ESRD in patients with type 2 diabetes, suggesting therapeutic strategies toward a goal to minimize glucose fluctuation.

Authors+Show Affiliations

From the Division of Nephrology (Y-FY, C-CH), China Medical University Hospital; School of Medicine (Y-FY, C-IL, C-SL, W-YL, C-CH, C-CL), College of Medicine, China Medical University; Department of Public Health (Y-FY, F-CS), China Medical University; Institute of Biostatistics (T-CL, S-YY), College of Public Health, China Medical University; Department of Healthcare Administration (T-CL), College of Medical and Health Science, Asia University; Department of Medical Research (C-IL, C-SL, C-CL), China Medical University Hospital; Department of Family Medicine (C-SL, W-YL, C-CL), China Medical University Hospital; Management Office for Health Data (J-HC, F-CS), China Medical University Hospital; and Research Center for Chinese Medicine & Accupuncture (J-HC), China Medical University, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26554779

Citation

Yang, Ya-Fei, et al. "Visit-to-Visit Glucose Variability Predicts the Development of End-Stage Renal Disease in Type 2 Diabetes: 10-Year Follow-Up of Taiwan Diabetes Study." Medicine, vol. 94, no. 44, 2015, pp. e1804.
Yang YF, Li TC, Li CI, et al. Visit-to-Visit Glucose Variability Predicts the Development of End-Stage Renal Disease in Type 2 Diabetes: 10-Year Follow-Up of Taiwan Diabetes Study. Medicine (Baltimore). 2015;94(44):e1804.
Yang, Y. F., Li, T. C., Li, C. I., Liu, C. S., Lin, W. Y., Yang, S. Y., Chiang, J. H., Huang, C. C., Sung, F. C., & Lin, C. C. (2015). Visit-to-Visit Glucose Variability Predicts the Development of End-Stage Renal Disease in Type 2 Diabetes: 10-Year Follow-Up of Taiwan Diabetes Study. Medicine, 94(44), e1804. https://doi.org/10.1097/MD.0000000000001804
Yang YF, et al. Visit-to-Visit Glucose Variability Predicts the Development of End-Stage Renal Disease in Type 2 Diabetes: 10-Year Follow-Up of Taiwan Diabetes Study. Medicine (Baltimore). 2015;94(44):e1804. PubMed PMID: 26554779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visit-to-Visit Glucose Variability Predicts the Development of End-Stage Renal Disease in Type 2 Diabetes: 10-Year Follow-Up of Taiwan Diabetes Study. AU - Yang,Ya-Fei, AU - Li,Tsai-Chung, AU - Li,Chia-Ing, AU - Liu,Chiu-Shong, AU - Lin,Wen-Yuan, AU - Yang,Sing-Yu, AU - Chiang,Jen-Huai, AU - Huang,Chiu-Ching, AU - Sung,Fung-Chang, AU - Lin,Cheng-Chieh, PY - 2015/11/12/entrez PY - 2015/11/12/pubmed PY - 2016/2/26/medline SP - e1804 EP - e1804 JF - Medicine JO - Medicine (Baltimore) VL - 94 IS - 44 N2 - The purpose of this study was to examine the association of glucose variability using coefficient of variation of fasting plasma glucose (FPG-CV) and coefficient of variation of glycated hemoglobin (HbA1c-CV) to end-stage renal disease (ESRD) in 31,841 Chinese patients with type 2 diabetes.Patients with type 2 diabetes enrolled in National Diabetes Care Management Program, aged ≧30 years, and free of ESRD (n = 31,841) in January 1, 2002 to December 31, 2004 were included. Extended Cox proportional hazards regression models with competing risk of all-cause mortality were used to evaluate risk factors on ESRD incidence. Patients were followed till 2012.After a median follow-up period of 8.23 years, 1642 patients developed ESRD, giving a crude incidence rate of 6.27/1000 person-years (6.36 for men, 6.19 for women). After the multivariate adjustment, both FPG-CV and HbA1c-CV were independent predictors of ESRD with corresponding hazard ratios of 1.20 (95% confidence interval [CI] 1.01, 1.41), 1.24 (95% CI 1.05, 1.46) in HbA1c-CV from fourth to fifth quintile and 1.23 (95% CI 1.03, 1.47) in FPG-CV from fifth quintile.One-year visit-to-visit glucose variability expressed by FPG-CV and HbA1c-CV predicted development of ESRD in patients with type 2 diabetes, suggesting therapeutic strategies toward a goal to minimize glucose fluctuation. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/26554779/Visit_to_Visit_Glucose_Variability_Predicts_the_Development_of_End_Stage_Renal_Disease_in_Type_2_Diabetes:_10_Year_Follow_Up_of_Taiwan_Diabetes_Study_ L2 - https://doi.org/10.1097/MD.0000000000001804 DB - PRIME DP - Unbound Medicine ER -