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Cardiometabolic Risk Profiles in Patients With Impaired Fasting Glucose and/or Hemoglobin A1c 5.7% to 6.4%: Evidence for a Gradient According to Diagnostic Criteria: The PREDAPS Study.
Medicine (Baltimore). 2015 Nov; 94(44):e1935.M

Abstract

It has been suggested that the early detection of individuals with prediabetes can help prevent cardiovascular diseases. The purpose of the current study was to examine the cardiometabolic risk profile in patients with prediabetes according to fasting plasma glucose (FPG) and/or hemoglobin A1c (HbA1c) criteria.Cross-sectional analysis from the 2022 patients in the Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes (PREDAPS Study) was developed. Four glycemic status groups were defined based on American Diabetes Association criteria. Information about cardiovascular risk factors-body mass index, waist circumference, blood pressure, cholesterol, triglycerides, uric acid, gamma-glutamyltransferase, glomerular filtration-and metabolic syndrome components were analyzed. Mean values of clinical and biochemical characteristics and frequencies of metabolic syndrome were estimated adjusting by age, sex, educational level, and family history of diabetes.A linear trend (P < 0.001) was observed in most of the cardiovascular risk factors and in all components of metabolic syndrome. Normoglycemic individuals had the best values, individuals with both criteria of prediabetes had the worst, and individuals with only one-HbA1c or FPG-criterion had an intermediate position. Metabolic syndrome was present in 15.0% (95% confidence interval: 12.6-17.4), 59.5% (54.0-64.9), 62.0% (56.0-68.0), and 76.2% (72.8-79.6) of individuals classified in normoglycemia, isolated HbA1c, isolated FPG, and both criteria groups, respectively.In conclusion, individuals with prediabetes, especially those with both criteria, have worse cardiometabolic risk profile than normoglycemic individuals. These results suggest the need to use both criteria in the clinical practice to identify those individuals with the highest cardiovascular risk, in order to offer them special attention with intensive lifestyle intervention programs.

Authors+Show Affiliations

From the Department of Preventive Medicine and Public Health (History of Science), Universidad Complutense de Madrid (CG-G, ER), Instituto de Investigación Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid (CG-G, ER), Torrero-La Paz Health Center, Zaragoza (FJS, JMM), Department of Preventive Medicine and Quality Management, Hospital General Universitario Gregorio Marañón, Madrid (AD-R), Raval-Sud Primary Care Team, Barcelona (JF-N), Martín de Vargas Health Center, Madrid (RS), Tafalla Health Center, Navarra (JD), Azpilagaña Primary Care Team, Navarra (PB-C), Porriño Health Center, Pontevedra (JG-S), Hereza Health Center, Madrid (SA), Zumaia Health Center, Guipúzcua (PE), La Victoria de Acentejo Health Center, Santa Cruz de Tenerife (LC), Es Castell Basic Health Unit, Islas Baleares (MS), Yecla Health Center, Murcia (JM-C), Family and Community Medicine Teaching Unit, Cantabria (PM), Endocrinology and Nutrition Department, Del Mar Hospital, Barcelona (AG); and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain (ER).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Observational Study

Language

eng

PubMed ID

26554799

Citation

Giráldez-García, Carolina, et al. "Cardiometabolic Risk Profiles in Patients With Impaired Fasting Glucose And/or Hemoglobin A1c 5.7% to 6.4%: Evidence for a Gradient According to Diagnostic Criteria: the PREDAPS Study." Medicine, vol. 94, no. 44, 2015, pp. e1935.
Giráldez-García C, Sangrós FJ, Díaz-Redondo A, et al. Cardiometabolic Risk Profiles in Patients With Impaired Fasting Glucose and/or Hemoglobin A1c 5.7% to 6.4%: Evidence for a Gradient According to Diagnostic Criteria: The PREDAPS Study. Medicine (Baltimore). 2015;94(44):e1935.
Giráldez-García, C., Sangrós, F. J., Díaz-Redondo, A., Franch-Nadal, J., Serrano, R., Díez, J., Buil-Cosiales, P., García-Soidán, F. J., Artola, S., Ezkurra, P., Carrillo, L., Millaruelo, J. M., Seguí, M., Martínez-Candela, J., Muñoz, P., Goday, A., & Regidor, E. (2015). Cardiometabolic Risk Profiles in Patients With Impaired Fasting Glucose and/or Hemoglobin A1c 5.7% to 6.4%: Evidence for a Gradient According to Diagnostic Criteria: The PREDAPS Study. Medicine, 94(44), e1935. https://doi.org/10.1097/MD.0000000000001935
Giráldez-García C, et al. Cardiometabolic Risk Profiles in Patients With Impaired Fasting Glucose And/or Hemoglobin A1c 5.7% to 6.4%: Evidence for a Gradient According to Diagnostic Criteria: the PREDAPS Study. Medicine (Baltimore). 2015;94(44):e1935. PubMed PMID: 26554799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiometabolic Risk Profiles in Patients With Impaired Fasting Glucose and/or Hemoglobin A1c 5.7% to 6.4%: Evidence for a Gradient According to Diagnostic Criteria: The PREDAPS Study. AU - Giráldez-García,Carolina, AU - Sangrós,F Javier, AU - Díaz-Redondo,Alicia, AU - Franch-Nadal,Josep, AU - Serrano,Rosario, AU - Díez,Javier, AU - Buil-Cosiales,Pilar, AU - García-Soidán,F Javier, AU - Artola,Sara, AU - Ezkurra,Patxi, AU - Carrillo,Lourdes, AU - Millaruelo,J Manuel, AU - Seguí,Mateu, AU - Martínez-Candela,Juan, AU - Muñoz,Pedro, AU - Goday,Albert, AU - Regidor,Enrique, AU - ,, PY - 2015/11/12/entrez PY - 2015/11/12/pubmed PY - 2016/2/19/medline SP - e1935 EP - e1935 JF - Medicine JO - Medicine (Baltimore) VL - 94 IS - 44 N2 - It has been suggested that the early detection of individuals with prediabetes can help prevent cardiovascular diseases. The purpose of the current study was to examine the cardiometabolic risk profile in patients with prediabetes according to fasting plasma glucose (FPG) and/or hemoglobin A1c (HbA1c) criteria.Cross-sectional analysis from the 2022 patients in the Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes (PREDAPS Study) was developed. Four glycemic status groups were defined based on American Diabetes Association criteria. Information about cardiovascular risk factors-body mass index, waist circumference, blood pressure, cholesterol, triglycerides, uric acid, gamma-glutamyltransferase, glomerular filtration-and metabolic syndrome components were analyzed. Mean values of clinical and biochemical characteristics and frequencies of metabolic syndrome were estimated adjusting by age, sex, educational level, and family history of diabetes.A linear trend (P < 0.001) was observed in most of the cardiovascular risk factors and in all components of metabolic syndrome. Normoglycemic individuals had the best values, individuals with both criteria of prediabetes had the worst, and individuals with only one-HbA1c or FPG-criterion had an intermediate position. Metabolic syndrome was present in 15.0% (95% confidence interval: 12.6-17.4), 59.5% (54.0-64.9), 62.0% (56.0-68.0), and 76.2% (72.8-79.6) of individuals classified in normoglycemia, isolated HbA1c, isolated FPG, and both criteria groups, respectively.In conclusion, individuals with prediabetes, especially those with both criteria, have worse cardiometabolic risk profile than normoglycemic individuals. These results suggest the need to use both criteria in the clinical practice to identify those individuals with the highest cardiovascular risk, in order to offer them special attention with intensive lifestyle intervention programs. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/26554799/Cardiometabolic_Risk_Profiles_in_Patients_With_Impaired_Fasting_Glucose_and/or_Hemoglobin_A1c_5_7_to_6_4:_Evidence_for_a_Gradient_According_to_Diagnostic_Criteria:_The_PREDAPS_Study_ L2 - https://doi.org/10.1097/MD.0000000000001935 DB - PRIME DP - Unbound Medicine ER -