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Photo-Fenton oxidation of 3-amino-5-methylisoxazole: a by-product from biological breakdown of some pharmaceutical compounds.
Environ Sci Pollut Res Int. 2017 Mar; 24(7):6195-6204.ES

Abstract

The present study aims to assess the removal of 3-amino-5-methylisoxazole (AMI), a recalcitrant by-product resulting from the biological breakdown of some pharmaceuticals, applying a solar photo-Fenton process assisted by ferrioxalate complexes (SPFF) (Fe3+/H2O2/oxalic acid/UVA-Vis) and classical solar photo-Fenton process (SPF) (Fe2+/H2O2/UVA-Vis). The oxidation ability of SPFF was evaluated at different iron/oxalate molar ratios (1:3, 1:6, and 1:9, with [total iron] = 3.58 × 10-2 mM and [oxalic acid] = 1.07 × 10-1, 2.14 × 10-1 and 3.22 × 10-1 mM, respectively) and pH values (3.5-6.5), using low iron contents (2.0 mg Fe3+ L-1). Additionally, the use of other organic ligands such as citrate and ethylenediamine-N,N'-disuccinic acid (EDDS) was tested. The oxidation power of the classical SPF was assessed at different pH values (2.8-4.0) using 2.0 mg Fe2+ per liter. Furthermore, the effect of AMI concentration (2-20 mg L-1), presence of inorganic ions (Cl-, SO42-, NO3-, HCO3-, NH4+), and radical scavengers (sodium azide and D-mannitol) on the SPF method at pH 3.5 was also assessed. Experiments were done using a lab-scale photoreactor with a compound parabolic collector (CPC) under simulated solar radiation. A pilot-scale assay was conducted using the best operation conditions. While at near neutral pH, an iron/oxalate molar ratio of 1:9 led to the removal of 72 % of AMI after 90 min of SPFF, at pH 3.5, an iron/oxalate molar ratio of 1:3 was enough to achieve complete AMI degradation (below the detection limit) after 30 min of reaction. The SPF process at pH 3.5 underwent a slower AMI degradation, reaching total AMI degradation after 40 min of reaction. The scale up of SPF process showed a good reproducibility. Oxalic and oxamic acids were identified as the main low-molecular-weight carboxylic acids detected during the pilot-scale SPF reaction. Graphical abstract ᅟ.

Authors+Show Affiliations

LSRE-Laboratory of Separation and Reaction Engineering-Associate Laboratory LSRE/LCM, Departamento de Engenharia Química, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal. Chemical Engineering Program-COPPE, Federal University of Rio de Janeiro, P.O. Box 68502, 21941-972, Rio de Janeiro, RJ, Brazil.LSRE-Laboratory of Separation and Reaction Engineering-Associate Laboratory LSRE/LCM, Departamento de Engenharia Química, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal.LSRE-Laboratory of Separation and Reaction Engineering-Associate Laboratory LSRE/LCM, Departamento de Engenharia Química, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal.Chemical Engineering Program-COPPE, Federal University of Rio de Janeiro, P.O. Box 68502, 21941-972, Rio de Janeiro, RJ, Brazil.LSRE-Laboratory of Separation and Reaction Engineering-Associate Laboratory LSRE/LCM, Departamento de Engenharia Química, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal.LSRE-Laboratory of Separation and Reaction Engineering-Associate Laboratory LSRE/LCM, Departamento de Engenharia Química, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal. vilar@fe.up.pt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26555882

Citation

Souza, Bianca M., et al. "Photo-Fenton Oxidation of 3-amino-5-methylisoxazole: a By-product From Biological Breakdown of some Pharmaceutical Compounds." Environmental Science and Pollution Research International, vol. 24, no. 7, 2017, pp. 6195-6204.
Souza BM, Marinho BA, Moreira FC, et al. Photo-Fenton oxidation of 3-amino-5-methylisoxazole: a by-product from biological breakdown of some pharmaceutical compounds. Environ Sci Pollut Res Int. 2017;24(7):6195-6204.
Souza, B. M., Marinho, B. A., Moreira, F. C., Dezotti, M. W. C., Boaventura, R. A. R., & Vilar, V. J. P. (2017). Photo-Fenton oxidation of 3-amino-5-methylisoxazole: a by-product from biological breakdown of some pharmaceutical compounds. Environmental Science and Pollution Research International, 24(7), 6195-6204. https://doi.org/10.1007/s11356-015-5690-1
Souza BM, et al. Photo-Fenton Oxidation of 3-amino-5-methylisoxazole: a By-product From Biological Breakdown of some Pharmaceutical Compounds. Environ Sci Pollut Res Int. 2017;24(7):6195-6204. PubMed PMID: 26555882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photo-Fenton oxidation of 3-amino-5-methylisoxazole: a by-product from biological breakdown of some pharmaceutical compounds. AU - Souza,Bianca M, AU - Marinho,Belisa A, AU - Moreira,Francisca C, AU - Dezotti,Márcia W C, AU - Boaventura,Rui A R, AU - Vilar,Vítor J P, Y1 - 2015/11/10/ PY - 2015/09/04/received PY - 2015/10/23/accepted PY - 2015/11/12/pubmed PY - 2017/5/23/medline PY - 2015/11/12/entrez KW - 3-amino-5-methylisoxazole KW - CPCs KW - Ferrioxalate complexes KW - Solar photo-Fenton SP - 6195 EP - 6204 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 24 IS - 7 N2 - The present study aims to assess the removal of 3-amino-5-methylisoxazole (AMI), a recalcitrant by-product resulting from the biological breakdown of some pharmaceuticals, applying a solar photo-Fenton process assisted by ferrioxalate complexes (SPFF) (Fe3+/H2O2/oxalic acid/UVA-Vis) and classical solar photo-Fenton process (SPF) (Fe2+/H2O2/UVA-Vis). The oxidation ability of SPFF was evaluated at different iron/oxalate molar ratios (1:3, 1:6, and 1:9, with [total iron] = 3.58 × 10-2 mM and [oxalic acid] = 1.07 × 10-1, 2.14 × 10-1 and 3.22 × 10-1 mM, respectively) and pH values (3.5-6.5), using low iron contents (2.0 mg Fe3+ L-1). Additionally, the use of other organic ligands such as citrate and ethylenediamine-N,N'-disuccinic acid (EDDS) was tested. The oxidation power of the classical SPF was assessed at different pH values (2.8-4.0) using 2.0 mg Fe2+ per liter. Furthermore, the effect of AMI concentration (2-20 mg L-1), presence of inorganic ions (Cl-, SO42-, NO3-, HCO3-, NH4+), and radical scavengers (sodium azide and D-mannitol) on the SPF method at pH 3.5 was also assessed. Experiments were done using a lab-scale photoreactor with a compound parabolic collector (CPC) under simulated solar radiation. A pilot-scale assay was conducted using the best operation conditions. While at near neutral pH, an iron/oxalate molar ratio of 1:9 led to the removal of 72 % of AMI after 90 min of SPFF, at pH 3.5, an iron/oxalate molar ratio of 1:3 was enough to achieve complete AMI degradation (below the detection limit) after 30 min of reaction. The SPF process at pH 3.5 underwent a slower AMI degradation, reaching total AMI degradation after 40 min of reaction. The scale up of SPF process showed a good reproducibility. Oxalic and oxamic acids were identified as the main low-molecular-weight carboxylic acids detected during the pilot-scale SPF reaction. Graphical abstract ᅟ. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/26555882/Photo_Fenton_oxidation_of_3_amino_5_methylisoxazole:_a_by_product_from_biological_breakdown_of_some_pharmaceutical_compounds_ L2 - https://dx.doi.org/10.1007/s11356-015-5690-1 DB - PRIME DP - Unbound Medicine ER -