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A new microplatform based on titanium dioxide nanofibers/graphene oxide nanosheets nanocomposite modified screen printed carbon electrode for electrochemical determination of adenine in the presence of guanine.
Biosens Bioelectron. 2016 Mar 15; 77:837-44.BB

Abstract

The current techniques for determining adenine have several shortcomings such as high cost, high time consumption, tedious pretreatment steps and the requirements for highly skilled personnel often restrict their use in routine analytical practice. This paper describes the development and utilization of a new nanocomposite consisting of titanium dioxide nanofibers (TNFs) and graphene oxide nanosheets (GONs) for screen printed carbon electrode (SPCE) modification. The synthesized GONs and TNFs were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). The modified electrode (TNFs/GONs/SPCE) was used for electrochemical characterization of adenine. The TNFs/GONs/SPCE exhibited an increase in peak current and the electron transfer kinetics and decrease in the overpotential for the oxidation reaction of adenine. Using differential pulse voltammetry (DPV), the prepared sensor showed good sensitivity for determining adenine in two ranges from 0.1-1 and 1-10 μM, with a detection limit (DL) of 1.71 nM. Electrochemical studies suggested that the TNFs/GONs/SPCE provided a synergistic augmentation on the voltammetric behavior of electrochemical oxidation of adenine, which was indicated by the improvement of anodic peak current and a decrease in anodic peak potential. The amount of adenine in pBudCE4.1 plasmid was determined via the proposed sensor and the result was in good compatibility with the sequence data of pBudCE4.1 plasmid.

Authors+Show Affiliations

Electroanalytical Chemistry Laboratory, Faculty of Science, University of Guilan, Namjoo Street, P.O. Box 1914, Rasht, Iran. Electronic address: arvand@guilan.ac.ir.Electroanalytical Chemistry Laboratory, Faculty of Science, University of Guilan, Namjoo Street, P.O. Box 1914, Rasht, Iran.Electroanalytical Chemistry Laboratory, Faculty of Science, University of Guilan, Namjoo Street, P.O. Box 1914, Rasht, Iran.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26556182

Citation

Arvand, Majid, et al. "A New Microplatform Based On Titanium Dioxide Nanofibers/graphene Oxide Nanosheets Nanocomposite Modified Screen Printed Carbon Electrode for Electrochemical Determination of Adenine in the Presence of Guanine." Biosensors & Bioelectronics, vol. 77, 2016, pp. 837-44.
Arvand M, Ghodsi N, Zanjanchi MA. A new microplatform based on titanium dioxide nanofibers/graphene oxide nanosheets nanocomposite modified screen printed carbon electrode for electrochemical determination of adenine in the presence of guanine. Biosens Bioelectron. 2016;77:837-44.
Arvand, M., Ghodsi, N., & Zanjanchi, M. A. (2016). A new microplatform based on titanium dioxide nanofibers/graphene oxide nanosheets nanocomposite modified screen printed carbon electrode for electrochemical determination of adenine in the presence of guanine. Biosensors & Bioelectronics, 77, 837-44. https://doi.org/10.1016/j.bios.2015.10.055
Arvand M, Ghodsi N, Zanjanchi MA. A New Microplatform Based On Titanium Dioxide Nanofibers/graphene Oxide Nanosheets Nanocomposite Modified Screen Printed Carbon Electrode for Electrochemical Determination of Adenine in the Presence of Guanine. Biosens Bioelectron. 2016 Mar 15;77:837-44. PubMed PMID: 26556182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new microplatform based on titanium dioxide nanofibers/graphene oxide nanosheets nanocomposite modified screen printed carbon electrode for electrochemical determination of adenine in the presence of guanine. AU - Arvand,Majid, AU - Ghodsi,Navid, AU - Zanjanchi,Mohammad Ali, Y1 - 2015/10/20/ PY - 2015/07/29/received PY - 2015/10/09/revised PY - 2015/10/19/accepted PY - 2015/11/12/entrez PY - 2015/11/12/pubmed PY - 2016/9/13/medline KW - Adenine KW - Graphene oxide nanosheets KW - Titanium dioxide nanofibers KW - pBudCE4.1 plasmid SP - 837 EP - 44 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 77 N2 - The current techniques for determining adenine have several shortcomings such as high cost, high time consumption, tedious pretreatment steps and the requirements for highly skilled personnel often restrict their use in routine analytical practice. This paper describes the development and utilization of a new nanocomposite consisting of titanium dioxide nanofibers (TNFs) and graphene oxide nanosheets (GONs) for screen printed carbon electrode (SPCE) modification. The synthesized GONs and TNFs were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). The modified electrode (TNFs/GONs/SPCE) was used for electrochemical characterization of adenine. The TNFs/GONs/SPCE exhibited an increase in peak current and the electron transfer kinetics and decrease in the overpotential for the oxidation reaction of adenine. Using differential pulse voltammetry (DPV), the prepared sensor showed good sensitivity for determining adenine in two ranges from 0.1-1 and 1-10 μM, with a detection limit (DL) of 1.71 nM. Electrochemical studies suggested that the TNFs/GONs/SPCE provided a synergistic augmentation on the voltammetric behavior of electrochemical oxidation of adenine, which was indicated by the improvement of anodic peak current and a decrease in anodic peak potential. The amount of adenine in pBudCE4.1 plasmid was determined via the proposed sensor and the result was in good compatibility with the sequence data of pBudCE4.1 plasmid. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/26556182/A_new_microplatform_based_on_titanium_dioxide_nanofibers/graphene_oxide_nanosheets_nanocomposite_modified_screen_printed_carbon_electrode_for_electrochemical_determination_of_adenine_in_the_presence_of_guanine_ DB - PRIME DP - Unbound Medicine ER -