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The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension.
Biomed Res Int 2015; 2015:827516BR

Abstract

Glaucoma is the second leading cause of blindness worldwide. Although the mechanism of the development of primary open-angle glaucoma (POAG) is not fully understood, elevated intraocular pressure (IOP) is considered the most important risk factor. Several vascular factors have also been identified as risk factors and can lead to hypoperfusion of the optic nerve head and thus may play an important role in the pathogenesis and progression of POAG. The results of the present study suggest that both high and low blood pressure (BP) are associated with an increased risk of POAG based on a comprehensive literature review. Elevated BP is associated with elevated IOP, leading to increased risk of glaucoma, but excessive BP lowering in glaucoma patients may cause a drop in ocular perfusion pressure (OPP) and subsequent ischemic injury. The relationship between IOP, OPP, and BP suggests that the relationship between BP and glaucoma progression is U-shaped.

Authors+Show Affiliations

HanGil Eye Hospital, Incheon 21388, Republic of Korea.Department of Ophthalmology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 403-720, Republic of Korea.Department of Ophthalmology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 403-720, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26557702

Citation

Chung, Hye Jin, et al. "The Association Between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension." BioMed Research International, vol. 2015, 2015, p. 827516.
Chung HJ, Hwang HB, Lee NY. The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension. Biomed Res Int. 2015;2015:827516.
Chung, H. J., Hwang, H. B., & Lee, N. Y. (2015). The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension. BioMed Research International, 2015, p. 827516. doi:10.1155/2015/827516.
Chung HJ, Hwang HB, Lee NY. The Association Between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension. Biomed Res Int. 2015;2015:827516. PubMed PMID: 26557702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension. AU - Chung,Hye Jin, AU - Hwang,Hyung Bin, AU - Lee,Na Young, Y1 - 2015/10/18/ PY - 2015/05/22/received PY - 2015/08/31/accepted PY - 2015/11/12/entrez PY - 2015/11/12/pubmed PY - 2016/8/30/medline SP - 827516 EP - 827516 JF - BioMed research international JO - Biomed Res Int VL - 2015 N2 - Glaucoma is the second leading cause of blindness worldwide. Although the mechanism of the development of primary open-angle glaucoma (POAG) is not fully understood, elevated intraocular pressure (IOP) is considered the most important risk factor. Several vascular factors have also been identified as risk factors and can lead to hypoperfusion of the optic nerve head and thus may play an important role in the pathogenesis and progression of POAG. The results of the present study suggest that both high and low blood pressure (BP) are associated with an increased risk of POAG based on a comprehensive literature review. Elevated BP is associated with elevated IOP, leading to increased risk of glaucoma, but excessive BP lowering in glaucoma patients may cause a drop in ocular perfusion pressure (OPP) and subsequent ischemic injury. The relationship between IOP, OPP, and BP suggests that the relationship between BP and glaucoma progression is U-shaped. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/26557702/The_Association_between_Primary_Open_Angle_Glaucoma_and_Blood_Pressure:_Two_Aspects_of_Hypertension_and_Hypotension_ L2 - https://dx.doi.org/10.1155/2015/827516 DB - PRIME DP - Unbound Medicine ER -