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Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma: A PRISMA-Compliant Meta-Analysis of Observational Studies.
Medicine (Baltimore) 2015; 94(45):e1729M

Abstract

The association between consumption of red and processed meat and non-Hodgkin lymphoma (NHL) remains unclear. We performed a meta-analysis of the published observational studies to explore this relationship.We searched databases in MEDLINE and EMBASE to identify observational studies which evaluated the association between consumption of red and processed meat and risk of NHL. Quality of included studies was evaluated using Newcastle-Ottawa Quality Assessment Scale (NOS). Random-effects models were used to calculate summary relative risk (SRR) and the corresponding 95% confidence interval (CI).We identified a total of 16 case-control and 4 prospective cohort studies, including 15,189 subjects with NHL. The SRR of NHL comparing the highest and lowest categories were 1.32 (95% CI: 1.12-1.55) for red meat and 1.17 (95% CI: 1.07-1.29) for processed meat intake. Stratified analysis indicated that a statistically significant risk association between consumption of red and processed meat and NHL risk was observed in case-control studies, but not in cohort studies. The SRR was 1.11 (95% CI: 1.04-1.18) for per 100 g/day increment in red meat intake and 1.28 (95% CI: 1.08-1.53) for per 50 g/day increment in processed meat intake. There was evidence of a nonlinear association for intake of processed meat, but not for intake of red meat.Findings from our meta-analysis indicate that consumption of red and processed meat may be related to NHL risk. More prospective epidemiological studies that control for important confounders and focus on the NHL risk related with different levels of meat consumption are required to clarify this association.

Authors+Show Affiliations

From the Department of Hematology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China (LY, SJ, WS, HH, XY, HL); Department of Hematology, Yancheng First People's Hospital, Yancheng, Jiangsu Province, China (JD); and Department of Internal medicine, Cancer Hospital of Nantong City and Affiliated Cancer Hospital of Nantong University, Nantong, Jiangsu Province, China (XX).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

26559248

Citation

Yang, Li, et al. "Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma: a PRISMA-Compliant Meta-Analysis of Observational Studies." Medicine, vol. 94, no. 45, 2015, pp. e1729.
Yang L, Dong J, Jiang S, et al. Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma: A PRISMA-Compliant Meta-Analysis of Observational Studies. Medicine (Baltimore). 2015;94(45):e1729.
Yang, L., Dong, J., Jiang, S., Shi, W., Xu, X., Huang, H., ... Liu, H. (2015). Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma: A PRISMA-Compliant Meta-Analysis of Observational Studies. Medicine, 94(45), pp. e1729. doi:10.1097/MD.0000000000001729.
Yang L, et al. Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma: a PRISMA-Compliant Meta-Analysis of Observational Studies. Medicine (Baltimore). 2015;94(45):e1729. PubMed PMID: 26559248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma: A PRISMA-Compliant Meta-Analysis of Observational Studies. AU - Yang,Li, AU - Dong,Jianming, AU - Jiang,Shenghua, AU - Shi,Wenyu, AU - Xu,Xiaohong, AU - Huang,Hongming, AU - You,Xuefen, AU - Liu,Hong, PY - 2015/11/13/entrez PY - 2015/11/13/pubmed PY - 2016/2/24/medline SP - e1729 EP - e1729 JF - Medicine JO - Medicine (Baltimore) VL - 94 IS - 45 N2 - The association between consumption of red and processed meat and non-Hodgkin lymphoma (NHL) remains unclear. We performed a meta-analysis of the published observational studies to explore this relationship.We searched databases in MEDLINE and EMBASE to identify observational studies which evaluated the association between consumption of red and processed meat and risk of NHL. Quality of included studies was evaluated using Newcastle-Ottawa Quality Assessment Scale (NOS). Random-effects models were used to calculate summary relative risk (SRR) and the corresponding 95% confidence interval (CI).We identified a total of 16 case-control and 4 prospective cohort studies, including 15,189 subjects with NHL. The SRR of NHL comparing the highest and lowest categories were 1.32 (95% CI: 1.12-1.55) for red meat and 1.17 (95% CI: 1.07-1.29) for processed meat intake. Stratified analysis indicated that a statistically significant risk association between consumption of red and processed meat and NHL risk was observed in case-control studies, but not in cohort studies. The SRR was 1.11 (95% CI: 1.04-1.18) for per 100 g/day increment in red meat intake and 1.28 (95% CI: 1.08-1.53) for per 50 g/day increment in processed meat intake. There was evidence of a nonlinear association for intake of processed meat, but not for intake of red meat.Findings from our meta-analysis indicate that consumption of red and processed meat may be related to NHL risk. More prospective epidemiological studies that control for important confounders and focus on the NHL risk related with different levels of meat consumption are required to clarify this association. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/26559248/Red_and_Processed_Meat_Consumption_Increases_Risk_for_Non_Hodgkin_Lymphoma:_A_PRISMA_Compliant_Meta_Analysis_of_Observational_Studies_ L2 - http://Insights.ovid.com/pubmed?pmid=26559248 DB - PRIME DP - Unbound Medicine ER -