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Lipoproteins and apolipoproteins in young nonobese Arab women with NIDDM treated with insulin.
Diabetes Care 1989; 12(5):325-31DC

Abstract

The effects of insulin on the lipid values of nonobese non-insulin-dependent diabetic (NIDDM) Arab women requiring insulin was investigated to find whether these patients have the same coronary artery risk factor related to lipid levels. In this study, 55 NIDDM women on insulin therapy (mean age 28 +/- 8.1 yr and duration of disease 5 +/- 1.2 yr) and 70 control subjects (matched for sex, age, and body mass index) were studied for their plasma levels of lipids, lipoproteins, and apolipoproteins. Concentrations of total cholesterol, very-low-density lipoprotein cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride (TG), LDL TG, high-density lipoprotein triglyceride (HDL TG), phospholipid, glucose, glycosylated hemoglobin (HbAtc), apolipoprotein B (apoB), LDL-apoB, and apoB/apoAl were significantly elevated in diabetic women compared with control subjects. There was no significant change in the levels of apoAll in plasma and lipoprotein fractions. Concentrations of HDL cholesterol (chol), HDL2-chol, HDL3-chol, plasma apoAl, HDL2-apoAl, HDL3-apoAl, and HDL-apoAl were significantly lower in diabetic women than in control subjects. There was no significant correlation between glucose or HbAtc and most of the lipids, lipoprotein lipids, and apolipoproteins measured. Despite normal body weight and insulin therapy, abnormalities in lipids, lipoprotein lipids, and apoB persisted in NIDDM patients compared with control subjects. Our data may favor an enhanced affinity toward atherosclerosis in these patients.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Kuwait University, Safat.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2656141

Citation

Al-Muhtaseb, N, et al. "Lipoproteins and Apolipoproteins in Young Nonobese Arab Women With NIDDM Treated With Insulin." Diabetes Care, vol. 12, no. 5, 1989, pp. 325-31.
Al-Muhtaseb N, Al-Yusuf AR, Abdella N, et al. Lipoproteins and apolipoproteins in young nonobese Arab women with NIDDM treated with insulin. Diabetes Care. 1989;12(5):325-31.
Al-Muhtaseb, N., Al-Yusuf, A. R., Abdella, N., & Fenech, F. (1989). Lipoproteins and apolipoproteins in young nonobese Arab women with NIDDM treated with insulin. Diabetes Care, 12(5), pp. 325-31.
Al-Muhtaseb N, et al. Lipoproteins and Apolipoproteins in Young Nonobese Arab Women With NIDDM Treated With Insulin. Diabetes Care. 1989;12(5):325-31. PubMed PMID: 2656141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoproteins and apolipoproteins in young nonobese Arab women with NIDDM treated with insulin. AU - Al-Muhtaseb,N, AU - Al-Yusuf,A R, AU - Abdella,N, AU - Fenech,F, PY - 1989/5/1/pubmed PY - 1989/5/1/medline PY - 1989/5/1/entrez SP - 325 EP - 31 JF - Diabetes care JO - Diabetes Care VL - 12 IS - 5 N2 - The effects of insulin on the lipid values of nonobese non-insulin-dependent diabetic (NIDDM) Arab women requiring insulin was investigated to find whether these patients have the same coronary artery risk factor related to lipid levels. In this study, 55 NIDDM women on insulin therapy (mean age 28 +/- 8.1 yr and duration of disease 5 +/- 1.2 yr) and 70 control subjects (matched for sex, age, and body mass index) were studied for their plasma levels of lipids, lipoproteins, and apolipoproteins. Concentrations of total cholesterol, very-low-density lipoprotein cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride (TG), LDL TG, high-density lipoprotein triglyceride (HDL TG), phospholipid, glucose, glycosylated hemoglobin (HbAtc), apolipoprotein B (apoB), LDL-apoB, and apoB/apoAl were significantly elevated in diabetic women compared with control subjects. There was no significant change in the levels of apoAll in plasma and lipoprotein fractions. Concentrations of HDL cholesterol (chol), HDL2-chol, HDL3-chol, plasma apoAl, HDL2-apoAl, HDL3-apoAl, and HDL-apoAl were significantly lower in diabetic women than in control subjects. There was no significant correlation between glucose or HbAtc and most of the lipids, lipoprotein lipids, and apolipoproteins measured. Despite normal body weight and insulin therapy, abnormalities in lipids, lipoprotein lipids, and apoB persisted in NIDDM patients compared with control subjects. Our data may favor an enhanced affinity toward atherosclerosis in these patients. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/2656141/Lipoproteins_and_apolipoproteins_in_young_nonobese_Arab_women_with_NIDDM_treated_with_insulin_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -