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Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution.

Abstract

Type 1 diabetes (T1D) is the second most frequent autoimmune disease in childhood. The long-term micro- and macro-vascular complications of diabetes are associated with the leading causes of disability and even mortality in young adults. Understanding the T1D etiology will allow the design of preventive strategies to avoid or delay the T1D onset and to help to maintain control after developing. T1D development involves genetic and environmental factors, such as birth delivery mode, use of antibiotics, and diet. Gut microbiota could be the link between environmental factors, the development of autoimmunity, and T1D. In this review, we will focus on the dietary factor and its relationship with the gut microbiota in the complex process involved in autoimmunity and T1D. The molecular mechanisms involved will also be addressed, and finally, evidence-based strategies for potential primary and secondary prevention of T1D will be discussed.

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  • Authors+Show Affiliations

    ,

    Department Nutrición y Metabolismo, Centro de Investigación en Alimentación y Desarrollo, A.C., Carr. La Victoria, Km. 0.6, Hermosillo, Sonora 83304, Mexico. esther.mejia83@gmail.com.

    Department Nutrición y Metabolismo, Centro de Investigación en Alimentación y Desarrollo, A.C., Carr. La Victoria, Km. 0.6, Hermosillo, Sonora 83304, Mexico. amc@ciad.mx.

    Source

    Nutrients 7:11 2015 Nov 06 pg 9171-84

    MeSH

    Animals
    Autoimmune Diseases
    Diabetes Mellitus, Type 1
    Diet
    Disease Models, Animal
    Gastrointestinal Microbiome
    Gastrointestinal Tract
    Humans
    Immune System

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26561831

    Citation

    Mejía-León, María E., and Ana M Calderón de la Barca. "Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution." Nutrients, vol. 7, no. 11, 2015, pp. 9171-84.
    Mejía-León ME, Barca AM. Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. Nutrients. 2015;7(11):9171-84.
    Mejía-León, M. E., & Barca, A. M. (2015). Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. Nutrients, 7(11), pp. 9171-84. doi:10.3390/nu7115461.
    Mejía-León ME, Barca AM. Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. Nutrients. 2015 Nov 6;7(11):9171-84. PubMed PMID: 26561831.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. AU - Mejía-León,María E, AU - Barca,Ana M Calderón de la, Y1 - 2015/11/06/ PY - 2015/07/09/received PY - 2015/10/17/revised PY - 2015/10/20/accepted PY - 2015/11/13/entrez PY - 2015/11/13/pubmed PY - 2016/8/31/medline KW - Bacteroides KW - Type 1 diabetes KW - autoimmunity KW - diet KW - dysbiosis KW - gut microbiota SP - 9171 EP - 84 JF - Nutrients JO - Nutrients VL - 7 IS - 11 N2 - Type 1 diabetes (T1D) is the second most frequent autoimmune disease in childhood. The long-term micro- and macro-vascular complications of diabetes are associated with the leading causes of disability and even mortality in young adults. Understanding the T1D etiology will allow the design of preventive strategies to avoid or delay the T1D onset and to help to maintain control after developing. T1D development involves genetic and environmental factors, such as birth delivery mode, use of antibiotics, and diet. Gut microbiota could be the link between environmental factors, the development of autoimmunity, and T1D. In this review, we will focus on the dietary factor and its relationship with the gut microbiota in the complex process involved in autoimmunity and T1D. The molecular mechanisms involved will also be addressed, and finally, evidence-based strategies for potential primary and secondary prevention of T1D will be discussed. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26561831/Diet_Microbiota_and_Immune_System_in_Type_1_Diabetes_Development_and_Evolution_ L2 - http://www.mdpi.com/resolver?pii=nu7115461 DB - PRIME DP - Unbound Medicine ER -