Tags

Type your tag names separated by a space and hit enter

Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution.
Nutrients 2015; 7(11):9171-84N

Abstract

Type 1 diabetes (T1D) is the second most frequent autoimmune disease in childhood. The long-term micro- and macro-vascular complications of diabetes are associated with the leading causes of disability and even mortality in young adults. Understanding the T1D etiology will allow the design of preventive strategies to avoid or delay the T1D onset and to help to maintain control after developing. T1D development involves genetic and environmental factors, such as birth delivery mode, use of antibiotics, and diet. Gut microbiota could be the link between environmental factors, the development of autoimmunity, and T1D. In this review, we will focus on the dietary factor and its relationship with the gut microbiota in the complex process involved in autoimmunity and T1D. The molecular mechanisms involved will also be addressed, and finally, evidence-based strategies for potential primary and secondary prevention of T1D will be discussed.

Authors+Show Affiliations

Department Nutrición y Metabolismo, Centro de Investigación en Alimentación y Desarrollo, A.C., Carr. La Victoria, Km. 0.6, Hermosillo, Sonora 83304, Mexico. esther.mejia83@gmail.com.Department Nutrición y Metabolismo, Centro de Investigación en Alimentación y Desarrollo, A.C., Carr. La Victoria, Km. 0.6, Hermosillo, Sonora 83304, Mexico. amc@ciad.mx.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26561831

Citation

Mejía-León, María E., and Ana M Calderón de la Barca. "Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution." Nutrients, vol. 7, no. 11, 2015, pp. 9171-84.
Mejía-León ME, Barca AM. Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. Nutrients. 2015;7(11):9171-84.
Mejía-León, M. E., & Barca, A. M. (2015). Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. Nutrients, 7(11), pp. 9171-84. doi:10.3390/nu7115461.
Mejía-León ME, Barca AM. Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. Nutrients. 2015 Nov 6;7(11):9171-84. PubMed PMID: 26561831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. AU - Mejía-León,María E, AU - Barca,Ana M Calderón de la, Y1 - 2015/11/06/ PY - 2015/07/09/received PY - 2015/10/17/revised PY - 2015/10/20/accepted PY - 2015/11/13/entrez PY - 2015/11/13/pubmed PY - 2016/8/31/medline KW - Bacteroides KW - Type 1 diabetes KW - autoimmunity KW - diet KW - dysbiosis KW - gut microbiota SP - 9171 EP - 84 JF - Nutrients JO - Nutrients VL - 7 IS - 11 N2 - Type 1 diabetes (T1D) is the second most frequent autoimmune disease in childhood. The long-term micro- and macro-vascular complications of diabetes are associated with the leading causes of disability and even mortality in young adults. Understanding the T1D etiology will allow the design of preventive strategies to avoid or delay the T1D onset and to help to maintain control after developing. T1D development involves genetic and environmental factors, such as birth delivery mode, use of antibiotics, and diet. Gut microbiota could be the link between environmental factors, the development of autoimmunity, and T1D. In this review, we will focus on the dietary factor and its relationship with the gut microbiota in the complex process involved in autoimmunity and T1D. The molecular mechanisms involved will also be addressed, and finally, evidence-based strategies for potential primary and secondary prevention of T1D will be discussed. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26561831/Diet_Microbiota_and_Immune_System_in_Type_1_Diabetes_Development_and_Evolution_ L2 - http://www.mdpi.com/resolver?pii=nu7115461 DB - PRIME DP - Unbound Medicine ER -