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Radiology of Cleft Lip and Palate: Imaging for the Prenatal Period and throughout Life.
Radiographics. 2015 Nov-Dec; 35(7):2053-63.R

Abstract

Recent advances in prenatal imaging have made possible the in utero diagnosis of cleft lip and palate and associated deformities. Postnatal diagnosis of cleft lip is made clinically, but imaging still plays a role in detection of associated abnormalities, surgical treatment planning, and screening for or surveillance of secondary deformities. This article describes the clinical entities of cleft lip with or without cleft palate (CLP) and isolated cleft palate and documents their prenatal and postnatal appearances at radiography, ultrasonography (US), magnetic resonance (MR) imaging, and computed tomography (CT). Imaging protocols and findings for prenatal screening, detection of associated anomalies, and evaluation of secondary deformities throughout life are described and illustrated. CLP and isolated cleft palate are distinct entities with shared radiologic appearances. Prenatal US and MR imaging can depict clefting of the lip or palate and associated anomalies. While two- and three-dimensional US often can depict cleft lip, visualization of cleft palate is more difficult, and repeat US or fetal MR imaging should be performed if cleft palate is suspected. Postnatal imaging can assist in identifying associated abnormalities and dentofacial deformities. Dentofacial sequelae of cleft lip and palate include missing and supernumerary teeth, oronasal fistulas, velopharyngeal insufficiency, hearing loss, maxillary growth restriction, and airway abnormalities. Secondary deformities can often be found incidentally at imaging performed for other purposes, but detection is necessary because they may have considerable implications for the patient.

Authors+Show Affiliations

From the College of Medicine, University of Tennessee Health Science Center, Memphis, Tenn (Z.R.A.); Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, Mass (Z.S.P.); and Department of Radiology, Le Bonheur Children's Hospital, 848 Adams Ave, Room G216, Memphis, TN 38103 (H.L.C., A.F.C.).From the College of Medicine, University of Tennessee Health Science Center, Memphis, Tenn (Z.R.A.); Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, Mass (Z.S.P.); and Department of Radiology, Le Bonheur Children's Hospital, 848 Adams Ave, Room G216, Memphis, TN 38103 (H.L.C., A.F.C.).From the College of Medicine, University of Tennessee Health Science Center, Memphis, Tenn (Z.R.A.); Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, Mass (Z.S.P.); and Department of Radiology, Le Bonheur Children's Hospital, 848 Adams Ave, Room G216, Memphis, TN 38103 (H.L.C., A.F.C.).From the College of Medicine, University of Tennessee Health Science Center, Memphis, Tenn (Z.R.A.); Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, Mass (Z.S.P.); and Department of Radiology, Le Bonheur Children's Hospital, 848 Adams Ave, Room G216, Memphis, TN 38103 (H.L.C., A.F.C.).

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26562237

Citation

Abramson, Zachary R., et al. "Radiology of Cleft Lip and Palate: Imaging for the Prenatal Period and Throughout Life." Radiographics : a Review Publication of the Radiological Society of North America, Inc, vol. 35, no. 7, 2015, pp. 2053-63.
Abramson ZR, Peacock ZS, Cohen HL, et al. Radiology of Cleft Lip and Palate: Imaging for the Prenatal Period and throughout Life. Radiographics. 2015;35(7):2053-63.
Abramson, Z. R., Peacock, Z. S., Cohen, H. L., & Choudhri, A. F. (2015). Radiology of Cleft Lip and Palate: Imaging for the Prenatal Period and throughout Life. Radiographics : a Review Publication of the Radiological Society of North America, Inc, 35(7), 2053-63. https://doi.org/10.1148/rg.2015150050
Abramson ZR, et al. Radiology of Cleft Lip and Palate: Imaging for the Prenatal Period and Throughout Life. Radiographics. 2015 Nov-Dec;35(7):2053-63. PubMed PMID: 26562237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radiology of Cleft Lip and Palate: Imaging for the Prenatal Period and throughout Life. AU - Abramson,Zachary R, AU - Peacock,Zachary S, AU - Cohen,Harris L, AU - Choudhri,Asim F, PY - 2015/11/13/entrez PY - 2015/11/13/pubmed PY - 2016/9/22/medline SP - 2053 EP - 63 JF - Radiographics : a review publication of the Radiological Society of North America, Inc JO - Radiographics VL - 35 IS - 7 N2 - Recent advances in prenatal imaging have made possible the in utero diagnosis of cleft lip and palate and associated deformities. Postnatal diagnosis of cleft lip is made clinically, but imaging still plays a role in detection of associated abnormalities, surgical treatment planning, and screening for or surveillance of secondary deformities. This article describes the clinical entities of cleft lip with or without cleft palate (CLP) and isolated cleft palate and documents their prenatal and postnatal appearances at radiography, ultrasonography (US), magnetic resonance (MR) imaging, and computed tomography (CT). Imaging protocols and findings for prenatal screening, detection of associated anomalies, and evaluation of secondary deformities throughout life are described and illustrated. CLP and isolated cleft palate are distinct entities with shared radiologic appearances. Prenatal US and MR imaging can depict clefting of the lip or palate and associated anomalies. While two- and three-dimensional US often can depict cleft lip, visualization of cleft palate is more difficult, and repeat US or fetal MR imaging should be performed if cleft palate is suspected. Postnatal imaging can assist in identifying associated abnormalities and dentofacial deformities. Dentofacial sequelae of cleft lip and palate include missing and supernumerary teeth, oronasal fistulas, velopharyngeal insufficiency, hearing loss, maxillary growth restriction, and airway abnormalities. Secondary deformities can often be found incidentally at imaging performed for other purposes, but detection is necessary because they may have considerable implications for the patient. SN - 1527-1323 UR - https://www.unboundmedicine.com/medline/citation/26562237/Radiology_of_Cleft_Lip_and_Palate:_Imaging_for_the_Prenatal_Period_and_throughout_Life_ L2 - https://pubs.rsna.org/doi/10.1148/rg.2015150050?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -