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Evaluation of oxidative and antioxidative parameters in generalized anxiety disorder.
Psychiatry Res 2015; 230(3):806-10PR

Abstract

Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder. The exact causes of GAD still unknown, in addition to neurochemical and neuroanatomic disorders, genetic and environmental factors are discussed in etiology. In our study we aimed to evaluate the oxidative metabolism's status and investigate the role of oxidative metabolites in GAD. Blood samples were taken from enrolled subjects in appropriate way and total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were studied in Harran University Biochemistry Labs. Results were compared between groups. The patients' TOS and OSI levels were significantly higher than control group. The patients' TAS levels were significantly lower than controls'. According to our findings, oxidative stress mechanism might have a role in GAD pathophysiology. In the future, total antioxidants may be used as a biologic marker in GAD etiology but more research is needed.

Authors+Show Affiliations

Clinic of Psychiatry, Ministry of Health, Diyarbakır Education and Research Hospital, Diyarbakır, Turkey.Harris County Psychiatric Center, University of Texas Health Science Center at Houston, TX, USA. Electronic address: drselek@yahoo.com.Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26564548

Citation

Emhan, Ali, et al. "Evaluation of Oxidative and Antioxidative Parameters in Generalized Anxiety Disorder." Psychiatry Research, vol. 230, no. 3, 2015, pp. 806-10.
Emhan A, Selek S, Bayazıt H, et al. Evaluation of oxidative and antioxidative parameters in generalized anxiety disorder. Psychiatry Res. 2015;230(3):806-10.
Emhan, A., Selek, S., Bayazıt, H., Fatih Karababa, İ., Katı, M., & Aksoy, N. (2015). Evaluation of oxidative and antioxidative parameters in generalized anxiety disorder. Psychiatry Research, 230(3), pp. 806-10. doi:10.1016/j.psychres.2015.11.001.
Emhan A, et al. Evaluation of Oxidative and Antioxidative Parameters in Generalized Anxiety Disorder. Psychiatry Res. 2015 Dec 30;230(3):806-10. PubMed PMID: 26564548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of oxidative and antioxidative parameters in generalized anxiety disorder. AU - Emhan,Ali, AU - Selek,Salih, AU - Bayazıt,Hüseyin, AU - Fatih Karababa,İbrahim, AU - Katı,Mahmut, AU - Aksoy,Nurten, Y1 - 2015/11/09/ PY - 2014/11/09/received PY - 2015/07/30/revised PY - 2015/11/02/accepted PY - 2015/11/14/entrez PY - 2015/11/14/pubmed PY - 2016/7/28/medline KW - Generalized anxiety disorder KW - Oxidative stress KW - Total antioxidant status KW - Total oxidant status SP - 806 EP - 10 JF - Psychiatry research JO - Psychiatry Res VL - 230 IS - 3 N2 - Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder. The exact causes of GAD still unknown, in addition to neurochemical and neuroanatomic disorders, genetic and environmental factors are discussed in etiology. In our study we aimed to evaluate the oxidative metabolism's status and investigate the role of oxidative metabolites in GAD. Blood samples were taken from enrolled subjects in appropriate way and total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were studied in Harran University Biochemistry Labs. Results were compared between groups. The patients' TOS and OSI levels were significantly higher than control group. The patients' TAS levels were significantly lower than controls'. According to our findings, oxidative stress mechanism might have a role in GAD pathophysiology. In the future, total antioxidants may be used as a biologic marker in GAD etiology but more research is needed. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/26564548/Evaluation_of_oxidative_and_antioxidative_parameters_in_generalized_anxiety_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(15)30616-8 DB - PRIME DP - Unbound Medicine ER -