Tags

Type your tag names separated by a space and hit enter

Estimating the critical immunity threshold for preventing hepatitis A outbreaks in men who have sex with men.
Epidemiol Infect. 2016 05; 144(7):1528-37.EI

Abstract

Several outbreaks of hepatitis A in men who have sex with men (MSM) were reported in the 1980s and 1990s in Australia and other countries. An effective hepatitis A virus (HAV) vaccine has been available in Australia since 1994 and is recommended for high-risk groups including MSM. No outbreaks of hepatitis A in Australian MSM have been reported since 1996. In this study, we aimed to estimate HAV transmissibility in MSM populations in order to inform targets for vaccine coverage in such populations. We used mathematical models of HAV transmission in a MSM population to estimate the basic reproduction number (R 0) and the probability of an HAV epidemic occurring as a function of the immune proportion. We estimated a plausible range for R 0 of 1·71-3·67 for HAV in MSM and that sustained epidemics cannot occur once the proportion immune to HAV is greater than ~70%. To our knowledge this is the first estimate of R 0 and the critical population immunity threshold for HAV transmission in MSM. As HAV is no longer endemic in Australia or in most other developed countries, vaccination is the only means of maintaining population immunity >70%. Our findings provide impetus to promote HAV vaccination in high-risk groups such as MSM.

Authors+Show Affiliations

The Kirby Institute,UNSW Australia,Sydney,NSW,Australia.The School of Public Health and Community Medicine,UNSW Australia,Sydney,NSW,Australia.École Nationale Supérieure de Techniques Avanceés,Palaiseau Cedex,France.The Kirby Institute,UNSW Australia,Sydney,NSW,Australia.The Kirby Institute,UNSW Australia,Sydney,NSW,Australia.South Eastern Area Laboratory Services,Prince of Wales Hospital,Sydney,NSW,Australia.The School of Public Health and Community Medicine,UNSW Australia,Sydney,NSW,Australia.Central Clinical School,Monash University,Melbourne,VIC,Australia.The Kirby Institute,UNSW Australia,Sydney,NSW,Australia.The Kirby Institute,UNSW Australia,Sydney,NSW,Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26566273

Citation

Regan, D G., et al. "Estimating the Critical Immunity Threshold for Preventing Hepatitis a Outbreaks in Men Who Have Sex With Men." Epidemiology and Infection, vol. 144, no. 7, 2016, pp. 1528-37.
Regan DG, Wood JG, Benevent C, et al. Estimating the critical immunity threshold for preventing hepatitis A outbreaks in men who have sex with men. Epidemiol Infect. 2016;144(7):1528-37.
Regan, D. G., Wood, J. G., Benevent, C., Ali, H., Smith, L. W., Robertson, P. W., Ferson, M. J., Fairley, C. K., Donovan, B., & Law, M. G. (2016). Estimating the critical immunity threshold for preventing hepatitis A outbreaks in men who have sex with men. Epidemiology and Infection, 144(7), 1528-37. https://doi.org/10.1017/S0950268815002605
Regan DG, et al. Estimating the Critical Immunity Threshold for Preventing Hepatitis a Outbreaks in Men Who Have Sex With Men. Epidemiol Infect. 2016;144(7):1528-37. PubMed PMID: 26566273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimating the critical immunity threshold for preventing hepatitis A outbreaks in men who have sex with men. AU - Regan,D G, AU - Wood,J G, AU - Benevent,C, AU - Ali,H, AU - Smith,L Watchirs, AU - Robertson,P W, AU - Ferson,M J, AU - Fairley,C K, AU - Donovan,B, AU - Law,M G, Y1 - 2015/11/13/ PY - 2015/11/14/entrez PY - 2015/11/14/pubmed PY - 2017/6/10/medline KW - Immunity threshold KW - men who have sex with men KW - reproduction number KW - transmission SP - 1528 EP - 37 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 144 IS - 7 N2 - Several outbreaks of hepatitis A in men who have sex with men (MSM) were reported in the 1980s and 1990s in Australia and other countries. An effective hepatitis A virus (HAV) vaccine has been available in Australia since 1994 and is recommended for high-risk groups including MSM. No outbreaks of hepatitis A in Australian MSM have been reported since 1996. In this study, we aimed to estimate HAV transmissibility in MSM populations in order to inform targets for vaccine coverage in such populations. We used mathematical models of HAV transmission in a MSM population to estimate the basic reproduction number (R 0) and the probability of an HAV epidemic occurring as a function of the immune proportion. We estimated a plausible range for R 0 of 1·71-3·67 for HAV in MSM and that sustained epidemics cannot occur once the proportion immune to HAV is greater than ~70%. To our knowledge this is the first estimate of R 0 and the critical population immunity threshold for HAV transmission in MSM. As HAV is no longer endemic in Australia or in most other developed countries, vaccination is the only means of maintaining population immunity >70%. Our findings provide impetus to promote HAV vaccination in high-risk groups such as MSM. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/26566273/Estimating_the_critical_immunity_threshold_for_preventing_hepatitis_A_outbreaks_in_men_who_have_sex_with_men_ L2 - https://www.cambridge.org/core/product/identifier/S0950268815002605/type/journal_article DB - PRIME DP - Unbound Medicine ER -