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Serum Levels of sRAGE Are Associated with Body Measurements, but Not Glycemic Parameters in Patients with Prediabetes.
Metab Syndr Relat Disord 2016; 14(1):33-9MS

Abstract

BACKGROUND

Our aim was to assess serum levels of the soluble receptor for advanced glycation end products (sRAGE) and to examine their association with anthropometric and metabolic parameters in patients with prediabetes and obese controls.

METHODS

The two study groups were composed of 42 patients with prediabetes and diabetic neuropathy and 42 age-, gender-, body weight (BW)-, and body mass index (BMI)-matched obese adults as the control group. Prediabetes was diagnosed by the following criteria issued by the American Diabetes Association: impaired fasting glucose [fasting plasma glucose (FPG) level of 100-125 mg/dL], impaired glucose tolerance (2 hr plasma glucose level of 140-199 mg/dL after a 75 grams oral glucose challenge), or a glycated hemoglobin (HbA1C) level of 5.7%-6.4%.

RESULTS

There were no differences between the groups in terms of age, gender distribution, BW, or BMI. Despite these similarities, patients with prediabetes had higher FPG, HbA1c, and 2-hr postchallenge glucose levels, higher systolic and diastolic blood pressure, and larger waist and hip circumferences compared with the obese controls. Lipid measurements, complete blood counts, kidney and liver function tests, high-sensitivity C-reactive protein, and sRAGE levels were similar between the two groups. We found significant negative correlations between sRAGE levels and BW, BMI, waist and hip circumferences, waist-to-hip ratios, and low-density lipoprotein (LDL) cholesterol levels. There were no significant correlations with other parameters, including demographic, metabolic, and blood pressure measurements.

CONCLUSIONS

In contrast to glycemic parameters, serum levels of sRAGE were negatively correlated with body measurements indicative of obesity in the prediabetic state. In addition, the negative correlation with LDL cholesterol levels suggests that sRAGE has a more robust association with metabolic syndrome than with prediabetes.

Authors+Show Affiliations

1 Department of Endocrinology and Metabolism, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .2 Department of Neurology, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .3 Department of Internal Medicine, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .4 Department of Biochemistry, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .1 Department of Endocrinology and Metabolism, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .4 Department of Biochemistry, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26569122

Citation

Guclu, Metin, et al. "Serum Levels of sRAGE Are Associated With Body Measurements, but Not Glycemic Parameters in Patients With Prediabetes." Metabolic Syndrome and Related Disorders, vol. 14, no. 1, 2016, pp. 33-9.
Guclu M, Ali A, Eroglu DU, et al. Serum Levels of sRAGE Are Associated with Body Measurements, but Not Glycemic Parameters in Patients with Prediabetes. Metab Syndr Relat Disord. 2016;14(1):33-9.
Guclu, M., Ali, A., Eroglu, D. U., Büyükuysal, S. O., Cander, S., & Ocak, N. (2016). Serum Levels of sRAGE Are Associated with Body Measurements, but Not Glycemic Parameters in Patients with Prediabetes. Metabolic Syndrome and Related Disorders, 14(1), pp. 33-9. doi:10.1089/met.2015.0078.
Guclu M, et al. Serum Levels of sRAGE Are Associated With Body Measurements, but Not Glycemic Parameters in Patients With Prediabetes. Metab Syndr Relat Disord. 2016;14(1):33-9. PubMed PMID: 26569122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum Levels of sRAGE Are Associated with Body Measurements, but Not Glycemic Parameters in Patients with Prediabetes. AU - Guclu,Metin, AU - Ali,Asuman, AU - Eroglu,Derya Ustun, AU - Büyükuysal,Sema Oral, AU - Cander,Soner, AU - Ocak,Nihal, Y1 - 2015/11/16/ PY - 2015/11/17/entrez PY - 2015/11/17/pubmed PY - 2016/12/30/medline SP - 33 EP - 9 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 14 IS - 1 N2 - BACKGROUND: Our aim was to assess serum levels of the soluble receptor for advanced glycation end products (sRAGE) and to examine their association with anthropometric and metabolic parameters in patients with prediabetes and obese controls. METHODS: The two study groups were composed of 42 patients with prediabetes and diabetic neuropathy and 42 age-, gender-, body weight (BW)-, and body mass index (BMI)-matched obese adults as the control group. Prediabetes was diagnosed by the following criteria issued by the American Diabetes Association: impaired fasting glucose [fasting plasma glucose (FPG) level of 100-125 mg/dL], impaired glucose tolerance (2 hr plasma glucose level of 140-199 mg/dL after a 75 grams oral glucose challenge), or a glycated hemoglobin (HbA1C) level of 5.7%-6.4%. RESULTS: There were no differences between the groups in terms of age, gender distribution, BW, or BMI. Despite these similarities, patients with prediabetes had higher FPG, HbA1c, and 2-hr postchallenge glucose levels, higher systolic and diastolic blood pressure, and larger waist and hip circumferences compared with the obese controls. Lipid measurements, complete blood counts, kidney and liver function tests, high-sensitivity C-reactive protein, and sRAGE levels were similar between the two groups. We found significant negative correlations between sRAGE levels and BW, BMI, waist and hip circumferences, waist-to-hip ratios, and low-density lipoprotein (LDL) cholesterol levels. There were no significant correlations with other parameters, including demographic, metabolic, and blood pressure measurements. CONCLUSIONS: In contrast to glycemic parameters, serum levels of sRAGE were negatively correlated with body measurements indicative of obesity in the prediabetic state. In addition, the negative correlation with LDL cholesterol levels suggests that sRAGE has a more robust association with metabolic syndrome than with prediabetes. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/26569122/Serum_Levels_of_sRAGE_Are_Associated_with_Body_Measurements_but_Not_Glycemic_Parameters_in_Patients_with_Prediabetes_ L2 - https://www.liebertpub.com/doi/full/10.1089/met.2015.0078?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -