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The Function of Autophagy in Neurodegenerative Diseases.
Int J Mol Sci. 2015 Nov 09; 16(11):26797-812.IJ

Abstract

Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired autophagic processes in neurons lead to improper homeostasis and neurodegeneration. Recent studies have suggested that impairments of the autophagic process are associated with several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and static encephalopathy of childhood with neurodegeneration in adulthood. In this review, we focus on the recent findings regarding the autophagic process and the involvement of autophagy in neurodegenerative diseases.

Authors+Show Affiliations

School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan. kiriyamay@kph.bunri-u.ac.jp.School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan. nochi@kph.bunri-u.ac.jp.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26569220

Citation

Kiriyama, Yoshimitsu, and Hiromi Nochi. "The Function of Autophagy in Neurodegenerative Diseases." International Journal of Molecular Sciences, vol. 16, no. 11, 2015, pp. 26797-812.
Kiriyama Y, Nochi H. The Function of Autophagy in Neurodegenerative Diseases. Int J Mol Sci. 2015;16(11):26797-812.
Kiriyama, Y., & Nochi, H. (2015). The Function of Autophagy in Neurodegenerative Diseases. International Journal of Molecular Sciences, 16(11), 26797-812. https://doi.org/10.3390/ijms161125990
Kiriyama Y, Nochi H. The Function of Autophagy in Neurodegenerative Diseases. Int J Mol Sci. 2015 Nov 9;16(11):26797-812. PubMed PMID: 26569220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Function of Autophagy in Neurodegenerative Diseases. AU - Kiriyama,Yoshimitsu, AU - Nochi,Hiromi, Y1 - 2015/11/09/ PY - 2015/09/27/received PY - 2015/10/30/revised PY - 2015/11/02/accepted PY - 2015/11/17/entrez PY - 2015/11/17/pubmed PY - 2016/8/30/medline KW - ALS KW - Alzheimer’s disease KW - Huntington’s disease KW - Parkinson’s disease KW - SENDA KW - autophagy KW - mitophagy SP - 26797 EP - 812 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 16 IS - 11 N2 - Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired autophagic processes in neurons lead to improper homeostasis and neurodegeneration. Recent studies have suggested that impairments of the autophagic process are associated with several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and static encephalopathy of childhood with neurodegeneration in adulthood. In this review, we focus on the recent findings regarding the autophagic process and the involvement of autophagy in neurodegenerative diseases. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/26569220/The_Function_of_Autophagy_in_Neurodegenerative_Diseases_ L2 - https://www.mdpi.com/resolver?pii=ijms161125990 DB - PRIME DP - Unbound Medicine ER -