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The influence of bexarotene, a selective agonist of the retinoid receptor X (RXR), and tazarotene, a selective agonist of the retinoid acid receptor (RAR), on bone metabolism in rats.
Adv Med Sci 2016; 61(1):85-9AM

Abstract

PURPOSE

The purpose of this study was to investigate the influence of selective agonists of the retinoid receptor X (RXR) and the retinoid acid receptor (RAR) on bone metabolism in rats.

METHODS

Thirty six male Wistar rats were divided into three groups: receiving bexarotene, or tazarotene, or to control group. Serum biochemical markers of bone turnover (osteocalcin - OC, tartrate resistant acid phosphatase 5 - TRACP5b and osteoprotegerin - OPG) and mechanical properties of bones were analyzed.

RESULTS

There was a significant decrease in the femur index value in groups receiving tazarotene and bexarotene on Day 14 (8% and 20% respectively, p=0.0039). On Day 28, 14 days after discontinuation of tazarotene and bexarotene, the difference in femur indexes was still significant (4% for T1-6 and B1-6, p=0.0270). In the bexarotene group an increase in mean plasma osteocalcin level and mean plasma TRACP5b level was detected. In the tazarotene group the mean osteocalcin level remained unchanged and the mean plasma TRACP5b level decreased. An increased yield stress was detected in groups receiving retinoids comparing to controls after 14 days of tazarotene and bexarotene administration.

CONCLUSION

Although bexarotene and tazarotene administration caused decrease in the femur index, mechanisms responsible for that effect seem to be different. Our results suggest that bexaroten increases bone turnover. On the contrary, tazaroten seems to have inhibitory effect on bone turnover. A counter influence of selective RAR and RXR agonists on the bone turnover might be the reason for inconsistency in results from published research concerning the influence of retinoids on bone metabolism.

Authors+Show Affiliations

Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland. Electronic address: beata.nowak@umed.wroc.pl.Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.Division of Biomedical Engineering and Experimental Mechanics, Wroclaw University of Technology, Wrocław, Poland.Division of Biomedical Engineering and Experimental Mechanics, Wroclaw University of Technology, Wrocław, Poland.Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26569440

Citation

Nowak, Beata, et al. "The Influence of Bexarotene, a Selective Agonist of the Retinoid Receptor X (RXR), and Tazarotene, a Selective Agonist of the Retinoid Acid Receptor (RAR), On Bone Metabolism in Rats." Advances in Medical Sciences, vol. 61, no. 1, 2016, pp. 85-9.
Nowak B, Matuszewska A, Filipiak J, et al. The influence of bexarotene, a selective agonist of the retinoid receptor X (RXR), and tazarotene, a selective agonist of the retinoid acid receptor (RAR), on bone metabolism in rats. Adv Med Sci. 2016;61(1):85-9.
Nowak, B., Matuszewska, A., Filipiak, J., Nikodem, A., Merwid-Ląd, A., Pieśniewska, M., ... Szeląg, A. (2016). The influence of bexarotene, a selective agonist of the retinoid receptor X (RXR), and tazarotene, a selective agonist of the retinoid acid receptor (RAR), on bone metabolism in rats. Advances in Medical Sciences, 61(1), pp. 85-9. doi:10.1016/j.advms.2015.09.001.
Nowak B, et al. The Influence of Bexarotene, a Selective Agonist of the Retinoid Receptor X (RXR), and Tazarotene, a Selective Agonist of the Retinoid Acid Receptor (RAR), On Bone Metabolism in Rats. Adv Med Sci. 2016;61(1):85-9. PubMed PMID: 26569440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of bexarotene, a selective agonist of the retinoid receptor X (RXR), and tazarotene, a selective agonist of the retinoid acid receptor (RAR), on bone metabolism in rats. AU - Nowak,Beata, AU - Matuszewska,Agnieszka, AU - Filipiak,Jarosław, AU - Nikodem,Anna, AU - Merwid-Ląd,Anna, AU - Pieśniewska,Małgorzata, AU - Fereniec-Gołębiewska,Lidia, AU - Kwiatkowska,Joanna, AU - Szeląg,Adam, Y1 - 2015/09/25/ PY - 2014/01/19/received PY - 2015/08/30/revised PY - 2015/09/10/accepted PY - 2015/11/17/entrez PY - 2015/11/17/pubmed PY - 2017/1/10/medline KW - Bone turnover KW - Retinoid acid receptor (RAR) KW - Retinoid receptor X (RXR) KW - Stress yield SP - 85 EP - 9 JF - Advances in medical sciences JO - Adv Med Sci VL - 61 IS - 1 N2 - PURPOSE: The purpose of this study was to investigate the influence of selective agonists of the retinoid receptor X (RXR) and the retinoid acid receptor (RAR) on bone metabolism in rats. METHODS: Thirty six male Wistar rats were divided into three groups: receiving bexarotene, or tazarotene, or to control group. Serum biochemical markers of bone turnover (osteocalcin - OC, tartrate resistant acid phosphatase 5 - TRACP5b and osteoprotegerin - OPG) and mechanical properties of bones were analyzed. RESULTS: There was a significant decrease in the femur index value in groups receiving tazarotene and bexarotene on Day 14 (8% and 20% respectively, p=0.0039). On Day 28, 14 days after discontinuation of tazarotene and bexarotene, the difference in femur indexes was still significant (4% for T1-6 and B1-6, p=0.0270). In the bexarotene group an increase in mean plasma osteocalcin level and mean plasma TRACP5b level was detected. In the tazarotene group the mean osteocalcin level remained unchanged and the mean plasma TRACP5b level decreased. An increased yield stress was detected in groups receiving retinoids comparing to controls after 14 days of tazarotene and bexarotene administration. CONCLUSION: Although bexarotene and tazarotene administration caused decrease in the femur index, mechanisms responsible for that effect seem to be different. Our results suggest that bexaroten increases bone turnover. On the contrary, tazaroten seems to have inhibitory effect on bone turnover. A counter influence of selective RAR and RXR agonists on the bone turnover might be the reason for inconsistency in results from published research concerning the influence of retinoids on bone metabolism. SN - 1898-4002 UR - https://www.unboundmedicine.com/medline/citation/26569440/The_influence_of_bexarotene_a_selective_agonist_of_the_retinoid_receptor_X__RXR__and_tazarotene_a_selective_agonist_of_the_retinoid_acid_receptor__RAR__on_bone_metabolism_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1896-1126(15)00048-6 DB - PRIME DP - Unbound Medicine ER -