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Imprinting of molecular recognition sites combined with π-donor-acceptor interactions using bis-aniline-crosslinked Au-CdSe/ZnS nanoparticles array on electrodes: Development of electrochemiluminescence sensor for the ultrasensitive and selective detection of 2-methyl-4-chlorophenoxyacetic acid.
Biosens Bioelectron. 2016 Mar 15; 77:1134-43.BB

Abstract

A novel strategy is reported for the fabrication of bis-aniline-crosslinked Au nanoparticles (NPs)-CdSe/ZnS quantum dots (QDs) array composite by facil one-step co-electropolymerization of thioaniline-functionalized AuNPs and thioaniline-functionalized CdSe/ZnS QDs onto thioaniline-functionalized Au elctrodes (AuE). Stable and enhanced cathodic electrochemiluminescence (ECL) of CdSe/ZnS QDs is observed on the modified electrode in neutral solution, suggesting promising applications in ECL sensing. An advanced ECL sensor is explored for detection of 2-methyl-4-chlorophenoxyacetic acid (MCPA) which quenches the ECL signal through electron-transfer pathway. The sensitive determination of MCPA with limit of detection (LOD) of 2.2 nmolL(-1) (S/N=3) is achieved by π-donor-acceptor interactions between MCPA and the bis-aniline bridging units. Impressively, the imprinting of molecular recognition sites into the bis-aniline-crosslinked AuNPs-CdSe/ZnS QDs array yields a functionalized electrode with an extremely sensitive response to MCPA in a linear range of 10 pmolL(-1)-50 μmolL(-1) with a LOD of 4.3 pmolL(-1 ()S/N=3). The proposed ECL sensor with high sensitivity, good selectivity, reproducibility and stability has been successfully applied for the determination of MCPA in real samples with satisfactory recoveries. In this study, ECL sensor combined the merits of QDs-ECL and molecularly imprinting technology is reported for the first time. The developed ECL sensor holds great promise for the fabrication of QDs-based ECL sensors with improved sensitivity and furthermore opens the door to wide applications of QDs-based ECL in food safety and environmental monitoring.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Yang Y
Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin Key Laboratory of Food Nutrition and Safety, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China.
Fang G
Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin Key Laboratory of Food Nutrition and Safety, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China. Electronic address: fangguozhen@tust.edu.cn.
Wang X
Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin Key Laboratory of Food Nutrition and Safety, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China.
Liu G
Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin Key Laboratory of Food Nutrition and Safety, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China.
Wang S
Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin Key Laboratory of Food Nutrition and Safety, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China; Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin 300457, China. Electronic address: s.wang@tust.edu.cn.

MeSH

2-Methyl-4-chlorophenoxyacetic AcidAniline CompoundsCadmium CompoundsCross-Linking ReagentsElectrochemistryEnvironmental MonitoringEnvironmental PollutantsEquipment DesignEquipment Failure AnalysisGoldHerbicidesLuminescent MeasurementsMetal NanoparticlesMicroarray AnalysisMicroelectrodesMolecular ImprintingQuantum DotsReproducibility of ResultsSelenium CompoundsSensitivity and SpecificityZinc Compounds

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26569444

Citation

Yang, Yukun, et al. "Imprinting of Molecular Recognition Sites Combined With Π-donor-acceptor Interactions Using Bis-aniline-crosslinked Au-CdSe/ZnS Nanoparticles Array On Electrodes: Development of Electrochemiluminescence Sensor for the Ultrasensitive and Selective Detection of 2-methyl-4-chlorophenoxyacetic Acid." Biosensors & Bioelectronics, vol. 77, 2016, pp. 1134-43.
Yang Y, Fang G, Wang X, et al. Imprinting of molecular recognition sites combined with π-donor-acceptor interactions using bis-aniline-crosslinked Au-CdSe/ZnS nanoparticles array on electrodes: Development of electrochemiluminescence sensor for the ultrasensitive and selective detection of 2-methyl-4-chlorophenoxyacetic acid. Biosens Bioelectron. 2016;77:1134-43.
Yang, Y., Fang, G., Wang, X., Liu, G., & Wang, S. (2016). Imprinting of molecular recognition sites combined with π-donor-acceptor interactions using bis-aniline-crosslinked Au-CdSe/ZnS nanoparticles array on electrodes: Development of electrochemiluminescence sensor for the ultrasensitive and selective detection of 2-methyl-4-chlorophenoxyacetic acid. Biosensors & Bioelectronics, 77, 1134-43. https://doi.org/10.1016/j.bios.2015.11.006
Yang Y, et al. Imprinting of Molecular Recognition Sites Combined With Π-donor-acceptor Interactions Using Bis-aniline-crosslinked Au-CdSe/ZnS Nanoparticles Array On Electrodes: Development of Electrochemiluminescence Sensor for the Ultrasensitive and Selective Detection of 2-methyl-4-chlorophenoxyacetic Acid. Biosens Bioelectron. 2016 Mar 15;77:1134-43. PubMed PMID: 26569444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imprinting of molecular recognition sites combined with π-donor-acceptor interactions using bis-aniline-crosslinked Au-CdSe/ZnS nanoparticles array on electrodes: Development of electrochemiluminescence sensor for the ultrasensitive and selective detection of 2-methyl-4-chlorophenoxyacetic acid. AU - Yang,Yukun, AU - Fang,Guozhen, AU - Wang,Xiaomin, AU - Liu,Guiyang, AU - Wang,Shuo, Y1 - 2015/11/09/ PY - 2015/08/05/received PY - 2015/10/25/revised PY - 2015/11/02/accepted PY - 2015/11/17/entrez PY - 2015/11/17/pubmed PY - 2016/9/13/medline KW - 2-methyl-4-chlorophenoxyacetic acid KW - Au nanoparticles KW - Electrochemiluminescence sensor KW - Molecularly imprinted polymers KW - Quantum dots KW - π-donor–acceptor interactions SP - 1134 EP - 43 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 77 N2 - A novel strategy is reported for the fabrication of bis-aniline-crosslinked Au nanoparticles (NPs)-CdSe/ZnS quantum dots (QDs) array composite by facil one-step co-electropolymerization of thioaniline-functionalized AuNPs and thioaniline-functionalized CdSe/ZnS QDs onto thioaniline-functionalized Au elctrodes (AuE). Stable and enhanced cathodic electrochemiluminescence (ECL) of CdSe/ZnS QDs is observed on the modified electrode in neutral solution, suggesting promising applications in ECL sensing. An advanced ECL sensor is explored for detection of 2-methyl-4-chlorophenoxyacetic acid (MCPA) which quenches the ECL signal through electron-transfer pathway. The sensitive determination of MCPA with limit of detection (LOD) of 2.2 nmolL(-1) (S/N=3) is achieved by π-donor-acceptor interactions between MCPA and the bis-aniline bridging units. Impressively, the imprinting of molecular recognition sites into the bis-aniline-crosslinked AuNPs-CdSe/ZnS QDs array yields a functionalized electrode with an extremely sensitive response to MCPA in a linear range of 10 pmolL(-1)-50 μmolL(-1) with a LOD of 4.3 pmolL(-1 ()S/N=3). The proposed ECL sensor with high sensitivity, good selectivity, reproducibility and stability has been successfully applied for the determination of MCPA in real samples with satisfactory recoveries. In this study, ECL sensor combined the merits of QDs-ECL and molecularly imprinting technology is reported for the first time. The developed ECL sensor holds great promise for the fabrication of QDs-based ECL sensors with improved sensitivity and furthermore opens the door to wide applications of QDs-based ECL in food safety and environmental monitoring. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/26569444/Imprinting_of_molecular_recognition_sites_combined_with_π_donor_acceptor_interactions_using_bis_aniline_crosslinked_Au_CdSe/ZnS_nanoparticles_array_on_electrodes:_Development_of_electrochemiluminescence_sensor_for_the_ultrasensitive_and_selective_detection_of_2_methyl_4_chlorophenoxyacetic_acid_ DB - PRIME DP - Unbound Medicine ER -
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