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Sjögren's syndrome-associated interstitial lung disease: A multicenter study.
Reumatol Clin. 2016 Jul-Aug; 12(4):201-5.RC

Abstract

Primary Sjögren syndrome (PSS) is a chronic inflammatory autoimmune disease. Interstitial lung disease (ILD) can be an extraglandular complication.

OBJECTIVE

To evaluate the clinical characteristics of patients diagnosed with PSS with ILD.

METHODS

Multicentre cohort study with 25 patients diagnosed with PSS and ILD. Data of PSS, prognostic factors, pulmonary involvement variables, complementary tests that suggest a worse diagnosis and treatment given were collected. EULAR index was measured for Sjögren's syndrome.

RESULTS

We identified 25 patients. In 15/25 the diagnosis of ILD was done before the diagnosis of PSS. The histopathological patterns found were: 12 NSIP, 5 UIP, 4 OP, 2 LIP. PFRs showed restrictive pattern. The majority of the patients received glucocorticoid therapy, antimalarial or immunosuppressive treatment.

CONCLUSIONS

Patients affected with PSS must be screened to catch a precocious diagnosis of ILD. The majority of the patients were diagnosed of ILD before being diagnosed of PSS. Multicenter cohorts are increasingly demanded and a multidisciplinary management is needed.

Authors+Show Affiliations

Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain. Electronic address: deliareinasanz@gmail.com.Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain.Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain.Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain.Servicio de Reumatología, Hospital de Sant Pau, Spain.Servicio de Reumatología, Hospital de Sant Pau, Spain.Servicio de Reumatología, Hospital Parc Taulí, Spain.Servicio de Reumatología, Hospital de Bellvitge, Spain.Servicio de Reumatología, Hospital de Granollers, Spain.Servicio de Neumología, Hospital Sant Joan Despí Moisès Broggi, Spain.Clinical Epidemiology Department, Consorci Sanitari Integral, Spain.Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng spa

PubMed ID

26573882

Citation

Reina, Delia, et al. "Sjögren's Syndrome-associated Interstitial Lung Disease: a Multicenter Study." Reumatologia Clinica, vol. 12, no. 4, 2016, pp. 201-5.
Reina D, Roig Vilaseca D, Torrente-Segarra V, et al. Sjögren's syndrome-associated interstitial lung disease: A multicenter study. Reumatol Clin. 2016;12(4):201-5.
Reina, D., Roig Vilaseca, D., Torrente-Segarra, V., Cerdà, D., Castellví, I., Díaz Torné, C., Moreno, M., Narváez, J., Ortiz, V., Blavia, R., Martín-Baranera, M., & Corominas, H. (2016). Sjögren's syndrome-associated interstitial lung disease: A multicenter study. Reumatologia Clinica, 12(4), 201-5. https://doi.org/10.1016/j.reuma.2015.09.003
Reina D, et al. Sjögren's Syndrome-associated Interstitial Lung Disease: a Multicenter Study. Reumatol Clin. 2016 Jul-Aug;12(4):201-5. PubMed PMID: 26573882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sjögren's syndrome-associated interstitial lung disease: A multicenter study. AU - Reina,Delia, AU - Roig Vilaseca,Daniel, AU - Torrente-Segarra,Vicenç, AU - Cerdà,Dacia, AU - Castellví,Ivan, AU - Díaz Torné,Cèsar, AU - Moreno,Mireia, AU - Narváez,Javier, AU - Ortiz,Vera, AU - Blavia,Rosana, AU - Martín-Baranera,Montserrat, AU - Corominas,Hèctor, Y1 - 2015/11/11/ PY - 2015/07/31/received PY - 2015/09/14/revised PY - 2015/09/24/accepted PY - 2015/11/18/entrez PY - 2015/11/18/pubmed PY - 2017/4/15/medline KW - Enfermedad pulmonar intersticial KW - Interstitial lung disease KW - Sjögren syndrome KW - Síndrome de Sjögren SP - 201 EP - 5 JF - Reumatologia clinica JO - Reumatol Clin VL - 12 IS - 4 N2 - UNLABELLED: Primary Sjögren syndrome (PSS) is a chronic inflammatory autoimmune disease. Interstitial lung disease (ILD) can be an extraglandular complication. OBJECTIVE: To evaluate the clinical characteristics of patients diagnosed with PSS with ILD. METHODS: Multicentre cohort study with 25 patients diagnosed with PSS and ILD. Data of PSS, prognostic factors, pulmonary involvement variables, complementary tests that suggest a worse diagnosis and treatment given were collected. EULAR index was measured for Sjögren's syndrome. RESULTS: We identified 25 patients. In 15/25 the diagnosis of ILD was done before the diagnosis of PSS. The histopathological patterns found were: 12 NSIP, 5 UIP, 4 OP, 2 LIP. PFRs showed restrictive pattern. The majority of the patients received glucocorticoid therapy, antimalarial or immunosuppressive treatment. CONCLUSIONS: Patients affected with PSS must be screened to catch a precocious diagnosis of ILD. The majority of the patients were diagnosed of ILD before being diagnosed of PSS. Multicenter cohorts are increasingly demanded and a multidisciplinary management is needed. SN - 1885-1398 UR - https://www.unboundmedicine.com/medline/citation/26573882/Sjögren's_syndrome_associated_interstitial_lung_disease:_A_multicenter_study_ L2 - http://www.elsevier.es/en/linksolver/pdf/pii/S1699-258X(15)00156-4 DB - PRIME DP - Unbound Medicine ER -