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A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery.
Vasc Endovascular Surg 2015; 49(8):220-7VE

Abstract

A pilot randomized controlled trial that evaluated the effect of remote ischemic preconditioning (RIPC) on clinical outcomes following major vascular surgery was performed. Eligible patients were those scheduled to undergo open abdominal aortic aneurysm repair, endovascular aortic aneurysm repair, carotid endarterectomy, and lower limb revascularization procedures. Patients were randomized to RIPC or to control groups. The primary outcome was a composite clinical end point comprising any of cardiovascular death, myocardial infarction, new-onset arrhythmia, cardiac arrest, congestive cardiac failure, cerebrovascular accident, renal failure requiring renal replacement therapy, mesenteric ischemia, and urgent cardiac revascularization. Secondary outcomes were components of the primary outcome and myocardial injury as assessed by serum troponin values. The primary outcome occurred in 19 (19.2%) of 99 controls and 14 (14.1%) of 99 RIPC group patients (P = .446). There were no significant differences in secondary outcomes. Our trial generated data that will guide future trials. Further trials are urgently needed.

Authors+Show Affiliations

Department of Vascular Surgery, University Hospital Limerick, Limerick, Ireland donagh1@hotmail.com.Department of Surgery Cork, University Hospital, Cork, Ireland.Department of Surgery, University Hospital Waterford, Waterford, Ireland.Department of Surgery, University Hospital Waterford, Waterford, Ireland.Department of Surgery, University Hospital Waterford, Waterford, Ireland.Department of Medicine, Graduate Entry Medical School, University of Limerick, Limerick, Ireland.Department of Medicine, Graduate Entry Medical School, University of Limerick, Limerick, Ireland.Department of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.Clinical Research Facility, National University of Ireland Galway, Galway, Ireland.Clinical Research Facility, National University of Ireland Galway, Galway, Ireland.Department of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.Department of Surgery, University Hospital Waterford, Waterford, Ireland.Department of Surgery, University Hospital Waterford, Waterford, Ireland.Department of Surgery, University Hospital Waterford, Waterford, Ireland.Clinical Research Facility, National University of Ireland Galway, Galway, Ireland.Department of Surgery Cork, University Hospital, Cork, Ireland.Department of Surgery Cork, University Hospital, Cork, Ireland.Department of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.Department of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.Department of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.Health Research Institute, University of Limerick, Limerick, Ireland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Pragmatic Clinical Trial
Randomized Controlled Trial

Language

eng

PubMed ID

26574485

Citation

Healy, D A., et al. "A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery." Vascular and Endovascular Surgery, vol. 49, no. 8, 2015, pp. 220-7.
Healy DA, Boyle E, McCartan D, et al. A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery. Vasc Endovascular Surg. 2015;49(8):220-7.
Healy, D. A., Boyle, E., McCartan, D., Bourke, M., Medani, M., Ferguson, J., ... Walsh, S. R. (2015). A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery. Vascular and Endovascular Surgery, 49(8), pp. 220-7. doi:10.1177/1538574415614404.
Healy DA, et al. A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery. Vasc Endovascular Surg. 2015;49(8):220-7. PubMed PMID: 26574485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery. AU - Healy,D A, AU - Boyle,E, AU - McCartan,D, AU - Bourke,M, AU - Medani,M, AU - Ferguson,J, AU - Yagoub,H, AU - Bashar,K, AU - O'Donnell,M, AU - Newell,J, AU - Canning,C, AU - McMonagle,M, AU - Dowdall,J, AU - Cross,S, AU - O'Daly,S, AU - Manning,B, AU - Fulton,G, AU - Kavanagh,E G, AU - Burke,P, AU - Grace,P A, AU - Moloney,M Clarke, AU - Walsh,S R, AU - ,, Y1 - 2015/11/16/ PY - 2015/11/18/entrez PY - 2015/11/18/pubmed PY - 2016/9/23/medline KW - aortic aneurysm KW - carotid endarterectomy KW - clinical trial KW - lower limb bypass KW - myocardial infarction KW - perioperative care KW - remote ischemic preconditioning KW - vascular surgery SP - 220 EP - 7 JF - Vascular and endovascular surgery JO - Vasc Endovascular Surg VL - 49 IS - 8 N2 - A pilot randomized controlled trial that evaluated the effect of remote ischemic preconditioning (RIPC) on clinical outcomes following major vascular surgery was performed. Eligible patients were those scheduled to undergo open abdominal aortic aneurysm repair, endovascular aortic aneurysm repair, carotid endarterectomy, and lower limb revascularization procedures. Patients were randomized to RIPC or to control groups. The primary outcome was a composite clinical end point comprising any of cardiovascular death, myocardial infarction, new-onset arrhythmia, cardiac arrest, congestive cardiac failure, cerebrovascular accident, renal failure requiring renal replacement therapy, mesenteric ischemia, and urgent cardiac revascularization. Secondary outcomes were components of the primary outcome and myocardial injury as assessed by serum troponin values. The primary outcome occurred in 19 (19.2%) of 99 controls and 14 (14.1%) of 99 RIPC group patients (P = .446). There were no significant differences in secondary outcomes. Our trial generated data that will guide future trials. Further trials are urgently needed. SN - 1938-9116 UR - https://www.unboundmedicine.com/medline/citation/26574485/A_MultiCenter_Pilot_Randomized_Controlled_Trial_of_Remote_Ischemic_Preconditioning_in_Major_Vascular_Surgery_ L2 - http://journals.sagepub.com/doi/full/10.1177/1538574415614404?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -