Tags

Type your tag names separated by a space and hit enter

Serum diamine oxidase activity in patients with histamine intolerance.
Int J Immunopathol Pharmacol. 2016 Mar; 29(1):105-11.IJ

Abstract

INTRODUCTION

Intolerance to various foods, excluding bona fide coeliac disease and lactose intolerance, represents a growing cause of patient visits to allergy clinics.Histamine intolerance is a long-known, multifaceted clinical condition triggered by histamine-rich foods and alcohol and/or by drugs that liberate histamine or block diamine oxidase (DAO), the main enzyme involved in the metabolism of ingested histamine. Histamine limitation diets impose complex, non-standardized restrictions that may severely impact the quality of life of patients.

METHODS

We retrospectively evaluated 14 patients who visited allergy outpatient facilities in northern Italy with a negative diagnosis for IgE-mediated food hypersensitivity, coeliac disease, conditions related to gastric hypersecretion, and systemic nickel hypersensitivity, and who previously underwent a histamine limitation diet with benefits for their main symptoms. Serum diamine oxidase levels and the clinical response to diamine oxidase supplementation were investigated.

RESULTS

We found that 10 out of 14 patients had serum DAO activity<10 U/mL, which was the threshold suggested as a cutoff for probable histamine intolerance. Moreover, 13 out of 14 patients subjectively reported a benefit in at least one of the disturbances related to food intolerances following diamine oxidase supplementation. The mean value (±SD) of diamine oxidase activity in the cohort of patients with histamine intolerance symptoms was 7.04±6.90 U/mL compared to 39.50±18.16 U/mL in 34 healthy controls (P=0.0031).

CONCLUSION

In patients with symptoms triggered by histamine-rich food, measuring the serum diamine oxidase activity can help identify subjects who can benefit from a histamine limitation diet and/or diamine oxidase supplementation.Properly designed, controlled studies investigating histamine intolerance that include histamine provocation are indispensable for providing insights into the area of food intolerances, which are currently primarily managed with non-scientific approaches in Italy.

Authors+Show Affiliations

Allergy Outpatients Service, General Hospital, P. le Ospedale n. 1, 24047 Treviglio, Italy.Laboratory of Cellular and Molecular Allergology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.Department of Medicine and Science of Ageing, G. D'Annunzio University, Chieti, Italy.Laboratory of Cellular and Molecular Allergology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy Department of Medicine and Science of Ageing, G. D'Annunzio University, Chieti, Italy s.burastero@hsr.it.

Pub Type(s)

Letter

Language

eng

PubMed ID

26574488

Citation

Manzotti, G, et al. "Serum Diamine Oxidase Activity in Patients With Histamine Intolerance." International Journal of Immunopathology and Pharmacology, vol. 29, no. 1, 2016, pp. 105-11.
Manzotti G, Breda D, Di Gioacchino M, et al. Serum diamine oxidase activity in patients with histamine intolerance. Int J Immunopathol Pharmacol. 2016;29(1):105-11.
Manzotti, G., Breda, D., Di Gioacchino, M., & Burastero, S. E. (2016). Serum diamine oxidase activity in patients with histamine intolerance. International Journal of Immunopathology and Pharmacology, 29(1), 105-11. https://doi.org/10.1177/0394632015617170
Manzotti G, et al. Serum Diamine Oxidase Activity in Patients With Histamine Intolerance. Int J Immunopathol Pharmacol. 2016;29(1):105-11. PubMed PMID: 26574488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum diamine oxidase activity in patients with histamine intolerance. AU - Manzotti,G, AU - Breda,D, AU - Di Gioacchino,M, AU - Burastero,S E, Y1 - 2015/11/16/ PY - 2015/06/02/received PY - 2015/10/22/accepted PY - 2015/11/18/entrez PY - 2015/11/18/pubmed PY - 2016/4/9/medline KW - diamine oxidase KW - food intolerance KW - histamine intolerance KW - low histamine diet SP - 105 EP - 11 JF - International journal of immunopathology and pharmacology JO - Int J Immunopathol Pharmacol VL - 29 IS - 1 N2 - INTRODUCTION: Intolerance to various foods, excluding bona fide coeliac disease and lactose intolerance, represents a growing cause of patient visits to allergy clinics.Histamine intolerance is a long-known, multifaceted clinical condition triggered by histamine-rich foods and alcohol and/or by drugs that liberate histamine or block diamine oxidase (DAO), the main enzyme involved in the metabolism of ingested histamine. Histamine limitation diets impose complex, non-standardized restrictions that may severely impact the quality of life of patients. METHODS: We retrospectively evaluated 14 patients who visited allergy outpatient facilities in northern Italy with a negative diagnosis for IgE-mediated food hypersensitivity, coeliac disease, conditions related to gastric hypersecretion, and systemic nickel hypersensitivity, and who previously underwent a histamine limitation diet with benefits for their main symptoms. Serum diamine oxidase levels and the clinical response to diamine oxidase supplementation were investigated. RESULTS: We found that 10 out of 14 patients had serum DAO activity<10 U/mL, which was the threshold suggested as a cutoff for probable histamine intolerance. Moreover, 13 out of 14 patients subjectively reported a benefit in at least one of the disturbances related to food intolerances following diamine oxidase supplementation. The mean value (±SD) of diamine oxidase activity in the cohort of patients with histamine intolerance symptoms was 7.04±6.90 U/mL compared to 39.50±18.16 U/mL in 34 healthy controls (P=0.0031). CONCLUSION: In patients with symptoms triggered by histamine-rich food, measuring the serum diamine oxidase activity can help identify subjects who can benefit from a histamine limitation diet and/or diamine oxidase supplementation.Properly designed, controlled studies investigating histamine intolerance that include histamine provocation are indispensable for providing insights into the area of food intolerances, which are currently primarily managed with non-scientific approaches in Italy. SN - 0394-6320 UR - https://www.unboundmedicine.com/medline/citation/26574488/Serum_diamine_oxidase_activity_in_patients_with_histamine_intolerance_ L2 - http://journals.sagepub.com/doi/full/10.1177/0394632015617170?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -