Tags

Type your tag names separated by a space and hit enter

Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study.
Eur J Dermatol. 2015 Nov-Dec; 25(6):595-601.EJ

Abstract

BACKGROUND

Necrobiosis lipoidica (NL) is a rare granulomatous disorder of unknown aetiology which can manifest in ulcerative skin lesions and is widely recognised in association with diabetes. We evaluated in total 100 patients to improve knowledge about the epidemiology and clinical course of NL. Additionally we focused on treatment options according to evidence level and expert opinion.

OBJECTIVE

To examine the clinical features of patients with necrobiosis lipoidica and to give recommendations for topical and systemic treatment.

MATERIALS & METHODS

This multicentre retrospective study covers data from 100 patients with the diagnosis of NL of the lower leg, treated during the period between 01/2006 and 06/2014. Data from 5 German dermatological centres with 23 men and 77 women with a median age of 52 years were evaluated. We also asked 15 dermatological experts for their opinions about ulceration, associated diseases and their preferences for treatment modalities of NL.

RESULTS

Patients' ages ranged from 15 to 95 years (median age 52 years, mean age 49.8 years). NL was significantly more common in women (77%). Ulceration of the NL was observed in 33% of cases, in particular in male patients and in patients with concomitant diabetes mellitus. Thyroidal disorders were found in 15% of all cases.

CONCLUSION

Our data confirm that female sex, middle age and endocrine disorders like diabetes mellitus or thyroid dysfunction are characteristics of patients suffering from NL. Existing therapeutic options were very variable and - according to the opinion of our experts - only a few highly effective.

Authors+Show Affiliations

Department of Dermatology, University Hospital Erlangen, Ulmenweg 18, 91054 Erlangen, Germany.Department of Dermatology, Venerology and Allergology, University Hospital Essen, Germany.Department of Dermatology, Venereology and Allergology, University Hospital Leipzig, Leipzig, Germany.Department of Dermatology, Venereology and Allergology, University Hospital Leipzig, Leipzig, Germany.Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.Department of Dermatology, University Hospital Erlangen, Ulmenweg 18, 91054 Erlangen, Germany.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26575980

Citation

Erfurt-Berge, Cornelia, et al. "Updated Results of 100 Patients On Clinical Features and Therapeutic Options in Necrobiosis Lipoidica in a Retrospective Multicentre Study." European Journal of Dermatology : EJD, vol. 25, no. 6, 2015, pp. 595-601.
Erfurt-Berge C, Dissemond J, Schwede K, et al. Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. Eur J Dermatol. 2015;25(6):595-601.
Erfurt-Berge, C., Dissemond, J., Schwede, K., Seitz, A. T., Al Ghazal, P., Wollina, U., & Renner, R. (2015). Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. European Journal of Dermatology : EJD, 25(6), 595-601. https://doi.org/10.1684/ejd.2015.2636
Erfurt-Berge C, et al. Updated Results of 100 Patients On Clinical Features and Therapeutic Options in Necrobiosis Lipoidica in a Retrospective Multicentre Study. Eur J Dermatol. 2015 Nov-Dec;25(6):595-601. PubMed PMID: 26575980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. AU - Erfurt-Berge,Cornelia, AU - Dissemond,Joachim, AU - Schwede,Katharina, AU - Seitz,Anna-Theresa, AU - Al Ghazal,Philipp, AU - Wollina,Uwe, AU - Renner,Regina, PY - 2015/11/18/entrez PY - 2015/11/18/pubmed PY - 2016/11/2/medline KW - experts’opinion KW - leg ulcer KW - necrobiosis lipoidica KW - treatment guidelines SP - 595 EP - 601 JF - European journal of dermatology : EJD JO - Eur J Dermatol VL - 25 IS - 6 N2 - BACKGROUND: Necrobiosis lipoidica (NL) is a rare granulomatous disorder of unknown aetiology which can manifest in ulcerative skin lesions and is widely recognised in association with diabetes. We evaluated in total 100 patients to improve knowledge about the epidemiology and clinical course of NL. Additionally we focused on treatment options according to evidence level and expert opinion. OBJECTIVE: To examine the clinical features of patients with necrobiosis lipoidica and to give recommendations for topical and systemic treatment. MATERIALS & METHODS: This multicentre retrospective study covers data from 100 patients with the diagnosis of NL of the lower leg, treated during the period between 01/2006 and 06/2014. Data from 5 German dermatological centres with 23 men and 77 women with a median age of 52 years were evaluated. We also asked 15 dermatological experts for their opinions about ulceration, associated diseases and their preferences for treatment modalities of NL. RESULTS: Patients' ages ranged from 15 to 95 years (median age 52 years, mean age 49.8 years). NL was significantly more common in women (77%). Ulceration of the NL was observed in 33% of cases, in particular in male patients and in patients with concomitant diabetes mellitus. Thyroidal disorders were found in 15% of all cases. CONCLUSION: Our data confirm that female sex, middle age and endocrine disorders like diabetes mellitus or thyroid dysfunction are characteristics of patients suffering from NL. Existing therapeutic options were very variable and - according to the opinion of our experts - only a few highly effective. SN - 1952-4013 UR - https://www.unboundmedicine.com/medline/citation/26575980/Updated_results_of_100_patients_on_clinical_features_and_therapeutic_options_in_necrobiosis_lipoidica_in_a_retrospective_multicentre_study_ L2 - http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ejd.2015.2636 DB - PRIME DP - Unbound Medicine ER -