Prime

Type your tag names separated by a space and hit enter

Protective Mechanisms of Flavonoids in Parkinson's Disease.

Abstract

Parkinson's disease is a chronic, debilitating neurodegenerative movement disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta region in human midbrain. To date, oxidative stress is the well accepted concept in the etiology and progression of Parkinson's disease. Hence, the therapeutic agent is targeted against suppressing and alleviating the oxidative stress-induced cellular damage. Within the past decades, an explosion of research discoveries has reported on the protective mechanisms of flavonoids, which are plant-based polyphenols, in the treatment of neurodegenerative disease using both in vitro and in vivo models. In this paper, we have reviewed the literature on the neuroprotective mechanisms of flavonoids in protecting the dopaminergic neurons hence reducing the symptoms of this movement disorder. The mechanism reviewed includes effect of flavonoids in activation of endogenous antioxidant enzymes, suppressing the lipid peroxidation, inhibition of inflammatory mediators, flavonoids as a mitochondrial target therapy, and modulation of gene expression in neuronal cells.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pathology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.

    ,

    Department of Pathology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.

    Discipline of Biomedicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD 4811, Australia.

    Source

    MeSH

    Antioxidants
    Dopaminergic Neurons
    Flavonoids
    Humans
    Lipid Peroxidation
    Mitochondria
    Mitogen-Activated Protein Kinases
    Oxidoreductases
    Parkinson Disease
    Protective Agents
    Reactive Oxygen Species

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    26576219

    Citation

    TY - JOUR T1 - Protective Mechanisms of Flavonoids in Parkinson's Disease. AU - Magalingam,Kasthuri Bai, AU - Radhakrishnan,Ammu Kutty, AU - Haleagrahara,Nagaraja, Y1 - 2015/10/20/ PY - 2014/10/22/received PY - 2015/1/29/accepted PY - 2015/10/20/epublish PY - 2015/11/18/entrez PY - 2015/11/18/pubmed PY - 2016/7/28/medline SP - 314560 EP - 314560 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2015 N2 - Parkinson's disease is a chronic, debilitating neurodegenerative movement disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta region in human midbrain. To date, oxidative stress is the well accepted concept in the etiology and progression of Parkinson's disease. Hence, the therapeutic agent is targeted against suppressing and alleviating the oxidative stress-induced cellular damage. Within the past decades, an explosion of research discoveries has reported on the protective mechanisms of flavonoids, which are plant-based polyphenols, in the treatment of neurodegenerative disease using both in vitro and in vivo models. In this paper, we have reviewed the literature on the neuroprotective mechanisms of flavonoids in protecting the dopaminergic neurons hence reducing the symptoms of this movement disorder. The mechanism reviewed includes effect of flavonoids in activation of endogenous antioxidant enzymes, suppressing the lipid peroxidation, inhibition of inflammatory mediators, flavonoids as a mitochondrial target therapy, and modulation of gene expression in neuronal cells. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/26576219/full_citation L2 - http://dx.doi.org/10.1155/2015/314560 ER -