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Protective Mechanisms of Flavonoids in Parkinson's Disease.
Oxid Med Cell Longev 2015; 2015:314560OM

Abstract

Parkinson's disease is a chronic, debilitating neurodegenerative movement disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta region in human midbrain. To date, oxidative stress is the well accepted concept in the etiology and progression of Parkinson's disease. Hence, the therapeutic agent is targeted against suppressing and alleviating the oxidative stress-induced cellular damage. Within the past decades, an explosion of research discoveries has reported on the protective mechanisms of flavonoids, which are plant-based polyphenols, in the treatment of neurodegenerative disease using both in vitro and in vivo models. In this paper, we have reviewed the literature on the neuroprotective mechanisms of flavonoids in protecting the dopaminergic neurons hence reducing the symptoms of this movement disorder. The mechanism reviewed includes effect of flavonoids in activation of endogenous antioxidant enzymes, suppressing the lipid peroxidation, inhibition of inflammatory mediators, flavonoids as a mitochondrial target therapy, and modulation of gene expression in neuronal cells.

Authors+Show Affiliations

Department of Pathology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.Department of Pathology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.Discipline of Biomedicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD 4811, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26576219

Citation

Magalingam, Kasthuri Bai, et al. "Protective Mechanisms of Flavonoids in Parkinson's Disease." Oxidative Medicine and Cellular Longevity, vol. 2015, 2015, p. 314560.
Magalingam KB, Radhakrishnan AK, Haleagrahara N. Protective Mechanisms of Flavonoids in Parkinson's Disease. Oxid Med Cell Longev. 2015;2015:314560.
Magalingam, K. B., Radhakrishnan, A. K., & Haleagrahara, N. (2015). Protective Mechanisms of Flavonoids in Parkinson's Disease. Oxidative Medicine and Cellular Longevity, 2015, p. 314560. doi:10.1155/2015/314560.
Magalingam KB, Radhakrishnan AK, Haleagrahara N. Protective Mechanisms of Flavonoids in Parkinson's Disease. Oxid Med Cell Longev. 2015;2015:314560. PubMed PMID: 26576219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective Mechanisms of Flavonoids in Parkinson's Disease. AU - Magalingam,Kasthuri Bai, AU - Radhakrishnan,Ammu Kutty, AU - Haleagrahara,Nagaraja, Y1 - 2015/10/20/ PY - 2014/10/22/received PY - 2015/01/29/accepted PY - 2015/11/18/entrez PY - 2015/11/18/pubmed PY - 2016/7/28/medline SP - 314560 EP - 314560 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2015 N2 - Parkinson's disease is a chronic, debilitating neurodegenerative movement disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta region in human midbrain. To date, oxidative stress is the well accepted concept in the etiology and progression of Parkinson's disease. Hence, the therapeutic agent is targeted against suppressing and alleviating the oxidative stress-induced cellular damage. Within the past decades, an explosion of research discoveries has reported on the protective mechanisms of flavonoids, which are plant-based polyphenols, in the treatment of neurodegenerative disease using both in vitro and in vivo models. In this paper, we have reviewed the literature on the neuroprotective mechanisms of flavonoids in protecting the dopaminergic neurons hence reducing the symptoms of this movement disorder. The mechanism reviewed includes effect of flavonoids in activation of endogenous antioxidant enzymes, suppressing the lipid peroxidation, inhibition of inflammatory mediators, flavonoids as a mitochondrial target therapy, and modulation of gene expression in neuronal cells. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/26576219/full_citation L2 - https://dx.doi.org/10.1155/2015/314560 DB - PRIME DP - Unbound Medicine ER -