Tags

Type your tag names separated by a space and hit enter

The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial.
J Psychopharmacol 2016; 30(2):140-51JP

Abstract

RATIONALE

Cannabis is mostly grown under illegal and unregulated circumstances, which seems to favour a product increasingly high in its main cannabinoid ∆-9-tetrahydrocannabinol (THC). ∆-9-tetrahydrocannabivarin (THCV) is a relatively untested cannabinoid which is said to be a cannabinoid receptor neutral antagonist, and may inhibit the effects of THC.

OBJECTIVES

To explore the safety and tolerability of repeated THCV administration and its effects on symptoms normally induced by THC in a sample of healthy volunteers.

METHODS

Ten male cannabis users (<25 use occasions) were recruited for this within-subjects, placebo-controlled, double-blind, cross-over pilot study. 10mg oral pure THCV or placebo were administered daily for five days, followed by 1mg intravenous THC on the fifth day.

RESULTS

THCV was well tolerated and subjectively indistinguishable from placebo. THC did not significantly increase psychotic symptoms, paranoia or impair short-term memory, while still producing significant intoxicating effects. Delayed verbal recall was impaired by THC and only occurred under placebo condition (Z=-2.201, p=0.028), suggesting a protective effect of THCV. THCV also inhibited THC-induced increased heart rate (Z=-2.193, p=0.028). Nine out of ten participants reported THC under THCV condition (compared to placebo) to be subjectively weaker or less intense (χ(2)=6.4, p=0.011). THCV in combination with THC significantly increased memory intrusions (Z=-2.155, p=0.031).

CONCLUSION

In this first study of THC and THCV, THCV inhibited some of the well-known effects of THC, while potentiating others. These findings need to be interpreted with caution due to a small sample size and lack of THC-induced psychotomimetic and memory-impairing effect, probably owing to the choice of dose.

Authors+Show Affiliations

Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK amir.englund@kcl.ac.uk.Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26577065

Citation

Englund, Amir, et al. "The Effect of Five Day Dosing With THCV On THC-induced Cognitive, Psychological and Physiological Effects in Healthy Male Human Volunteers: a Placebo-controlled, Double-blind, Crossover Pilot Trial." Journal of Psychopharmacology (Oxford, England), vol. 30, no. 2, 2016, pp. 140-51.
Englund A, Atakan Z, Kralj A, et al. The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. J Psychopharmacol (Oxford). 2016;30(2):140-51.
Englund, A., Atakan, Z., Kralj, A., Tunstall, N., Murray, R., & Morrison, P. (2016). The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. Journal of Psychopharmacology (Oxford, England), 30(2), pp. 140-51. doi:10.1177/0269881115615104.
Englund A, et al. The Effect of Five Day Dosing With THCV On THC-induced Cognitive, Psychological and Physiological Effects in Healthy Male Human Volunteers: a Placebo-controlled, Double-blind, Crossover Pilot Trial. J Psychopharmacol (Oxford). 2016;30(2):140-51. PubMed PMID: 26577065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. AU - Englund,Amir, AU - Atakan,Zerrin, AU - Kralj,Aleksandra, AU - Tunstall,Nigel, AU - Murray,Robin, AU - Morrison,Paul, Y1 - 2015/11/17/ PY - 2015/11/19/entrez PY - 2015/11/19/pubmed PY - 2016/11/1/medline KW - THC KW - THCV KW - cannabinoid KW - cannabis KW - human KW - memory KW - psychosis KW - Δ9-tetrahydrocannabinol KW - Δ9-tetrahydrocannabivarin SP - 140 EP - 51 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 30 IS - 2 N2 - RATIONALE: Cannabis is mostly grown under illegal and unregulated circumstances, which seems to favour a product increasingly high in its main cannabinoid ∆-9-tetrahydrocannabinol (THC). ∆-9-tetrahydrocannabivarin (THCV) is a relatively untested cannabinoid which is said to be a cannabinoid receptor neutral antagonist, and may inhibit the effects of THC. OBJECTIVES: To explore the safety and tolerability of repeated THCV administration and its effects on symptoms normally induced by THC in a sample of healthy volunteers. METHODS: Ten male cannabis users (<25 use occasions) were recruited for this within-subjects, placebo-controlled, double-blind, cross-over pilot study. 10mg oral pure THCV or placebo were administered daily for five days, followed by 1mg intravenous THC on the fifth day. RESULTS: THCV was well tolerated and subjectively indistinguishable from placebo. THC did not significantly increase psychotic symptoms, paranoia or impair short-term memory, while still producing significant intoxicating effects. Delayed verbal recall was impaired by THC and only occurred under placebo condition (Z=-2.201, p=0.028), suggesting a protective effect of THCV. THCV also inhibited THC-induced increased heart rate (Z=-2.193, p=0.028). Nine out of ten participants reported THC under THCV condition (compared to placebo) to be subjectively weaker or less intense (χ(2)=6.4, p=0.011). THCV in combination with THC significantly increased memory intrusions (Z=-2.155, p=0.031). CONCLUSION: In this first study of THC and THCV, THCV inhibited some of the well-known effects of THC, while potentiating others. These findings need to be interpreted with caution due to a small sample size and lack of THC-induced psychotomimetic and memory-impairing effect, probably owing to the choice of dose. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/26577065/The_effect_of_five_day_dosing_with_THCV_on_THC_induced_cognitive_psychological_and_physiological_effects_in_healthy_male_human_volunteers:_A_placebo_controlled_double_blind_crossover_pilot_trial_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881115615104?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -