Tags

Type your tag names separated by a space and hit enter

Partial Protection Induced by 2011-2012 Influenza Vaccine Against Serologically Evidenced A(H3N2) Influenza Virus Infections in Elderly Institutionalized People.
Adv Exp Med Biol 2016; 897:45-53AE

Abstract

Ninety-two institutionalized elderly subjects were vaccinated with trivalent influenza inactivated vaccine available for the 2011-2012 season, characterized by a prevalent circulation of A(H3N2) influenza viruses (A/Victoria/208-clade) presenting antigenic and genetic patterns different from the A(H3N2) vaccine component (A/Perth/16/2009-clade). Haemagglutination inhibiting (HI) antibody titers were determined in sera collected before, 1 and 6 months after vaccination and patients were considered positive for serological evidence of recent infection if they had a seroconversion on comparing HI titers found in sera collected 1 and 6 months after vaccination. No seroconversions were found against A(H1N1) and B vaccine components. Instead 17 volunteers seroconverted against all or at least some of the different A(H3N2) antigens examined, i.e. the 2011-2012 (A/Perth/16/2009) and the 2012-2013 (A/Victoria/361/2011) vaccine strains and four drifted viruses belonging to the A/Victoria/208-clade circulating in the area were the elderly people were living. The results obtained suggest that influenza infections in the vaccinated volunteers might be due both to a poor match between vaccine and circulating A(H3N2) viruses, since 1 month after vaccination 15 of the 17 volunteers had post-vaccination HI titers considered protective (≥40) against the A(H3N2) vaccine antigen, but not always against the epidemic strains, and to a waning of vaccine induced immune response, since 6 months after vaccination HI titers of non-infected volunteers were found to be decreased as compared with those found 1 month after vaccination.

Authors+Show Affiliations

Department of Experimental Medicine, University of Perugia, Piazza Gambuli, 06132, Perugia, Italy.Department of Experimental Medicine, University of Perugia, Piazza Gambuli, 06132, Perugia, Italy.RP Bittoni, Città della Pieve, Perugia, Italy.Azienda USL2, Foligno, Italy.Department of Experimental Medicine, University of Perugia, Piazza Gambuli, 06132, Perugia, Italy. annaiorio42@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26577530

Citation

Camilloni, Barbara, et al. "Partial Protection Induced By 2011-2012 Influenza Vaccine Against Serologically Evidenced A(H3N2) Influenza Virus Infections in Elderly Institutionalized People." Advances in Experimental Medicine and Biology, vol. 897, 2016, pp. 45-53.
Camilloni B, Basileo M, Menculini G, et al. Partial Protection Induced by 2011-2012 Influenza Vaccine Against Serologically Evidenced A(H3N2) Influenza Virus Infections in Elderly Institutionalized People. Adv Exp Med Biol. 2016;897:45-53.
Camilloni, B., Basileo, M., Menculini, G., Tozzi, P., & Iorio, A. M. (2016). Partial Protection Induced by 2011-2012 Influenza Vaccine Against Serologically Evidenced A(H3N2) Influenza Virus Infections in Elderly Institutionalized People. Advances in Experimental Medicine and Biology, 897, pp. 45-53. doi:10.1007/5584_2015_5003.
Camilloni B, et al. Partial Protection Induced By 2011-2012 Influenza Vaccine Against Serologically Evidenced A(H3N2) Influenza Virus Infections in Elderly Institutionalized People. Adv Exp Med Biol. 2016;897:45-53. PubMed PMID: 26577530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Partial Protection Induced by 2011-2012 Influenza Vaccine Against Serologically Evidenced A(H3N2) Influenza Virus Infections in Elderly Institutionalized People. AU - Camilloni,Barbara, AU - Basileo,Michela, AU - Menculini,Giuseppe, AU - Tozzi,Paolo, AU - Iorio,Anna Maria, PY - 2015/11/19/entrez PY - 2015/11/19/pubmed PY - 2016/8/19/medline KW - Antigenic drift KW - Influenza virus KW - Protection KW - Vaccination SP - 45 EP - 53 JF - Advances in experimental medicine and biology JO - Adv. Exp. Med. Biol. VL - 897 N2 - Ninety-two institutionalized elderly subjects were vaccinated with trivalent influenza inactivated vaccine available for the 2011-2012 season, characterized by a prevalent circulation of A(H3N2) influenza viruses (A/Victoria/208-clade) presenting antigenic and genetic patterns different from the A(H3N2) vaccine component (A/Perth/16/2009-clade). Haemagglutination inhibiting (HI) antibody titers were determined in sera collected before, 1 and 6 months after vaccination and patients were considered positive for serological evidence of recent infection if they had a seroconversion on comparing HI titers found in sera collected 1 and 6 months after vaccination. No seroconversions were found against A(H1N1) and B vaccine components. Instead 17 volunteers seroconverted against all or at least some of the different A(H3N2) antigens examined, i.e. the 2011-2012 (A/Perth/16/2009) and the 2012-2013 (A/Victoria/361/2011) vaccine strains and four drifted viruses belonging to the A/Victoria/208-clade circulating in the area were the elderly people were living. The results obtained suggest that influenza infections in the vaccinated volunteers might be due both to a poor match between vaccine and circulating A(H3N2) viruses, since 1 month after vaccination 15 of the 17 volunteers had post-vaccination HI titers considered protective (≥40) against the A(H3N2) vaccine antigen, but not always against the epidemic strains, and to a waning of vaccine induced immune response, since 6 months after vaccination HI titers of non-infected volunteers were found to be decreased as compared with those found 1 month after vaccination. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/26577530/Partial_Protection_Induced_by_2011_2012_Influenza_Vaccine_Against_Serologically_Evidenced_A_H3N2__Influenza_Virus_Infections_in_Elderly_Institutionalized_People_ L2 - https://dx.doi.org/10.1007/5584_2015_5003 DB - PRIME DP - Unbound Medicine ER -