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Fat Quality Influences the Obesogenic Effect of High Fat Diets.
Nutrients 2015; 7(11):9475-91N

Abstract

High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

Authors+Show Affiliations

Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. rcrescen@unina.it.Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. francibianco@yahoo.it.Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. arimazzoli@hotmail.it.Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. antonia.giacco@hotmail.it.Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. cancelliererosa@gmail.com.Department of Chemical Sciences, Federico II University, Via Cinthia, 80138 Naples, Italy. difabio@unina.it.Department of Chemical Sciences, Federico II University, Via Cinthia, 80138 Naples, Italy. zarrelli@unina.it. Inter-University Consortium SannioTech, Piazza San G. Moscati, 82030 Apollosa (BN), Italy. zarrelli@unina.it.Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. liverini@unina.it.Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. susiossa@unina.it.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26580650

Citation

Crescenzo, Raffaella, et al. "Fat Quality Influences the Obesogenic Effect of High Fat Diets." Nutrients, vol. 7, no. 11, 2015, pp. 9475-91.
Crescenzo R, Bianco F, Mazzoli A, et al. Fat Quality Influences the Obesogenic Effect of High Fat Diets. Nutrients. 2015;7(11):9475-91.
Crescenzo, R., Bianco, F., Mazzoli, A., Giacco, A., Cancelliere, R., di Fabio, G., ... Iossa, S. (2015). Fat Quality Influences the Obesogenic Effect of High Fat Diets. Nutrients, 7(11), pp. 9475-91. doi:10.3390/nu7115480.
Crescenzo R, et al. Fat Quality Influences the Obesogenic Effect of High Fat Diets. Nutrients. 2015 Nov 16;7(11):9475-91. PubMed PMID: 26580650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fat Quality Influences the Obesogenic Effect of High Fat Diets. AU - Crescenzo,Raffaella, AU - Bianco,Francesca, AU - Mazzoli,Arianna, AU - Giacco,Antonia, AU - Cancelliere,Rosa, AU - di Fabio,Giovanni, AU - Zarrelli,Armando, AU - Liverini,Giovanna, AU - Iossa,Susanna, Y1 - 2015/11/16/ PY - 2015/09/22/received PY - 2015/11/02/revised PY - 2015/11/06/accepted PY - 2015/11/19/entrez PY - 2015/11/19/pubmed PY - 2016/8/31/medline KW - hepatic steatosis KW - high fat diet KW - lipid peroxidation KW - unsaturated fatty acids SP - 9475 EP - 91 JF - Nutrients JO - Nutrients VL - 7 IS - 11 N2 - High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26580650/Fat_Quality_Influences_the_Obesogenic_Effect_of_High_Fat_Diets_ L2 - http://www.mdpi.com/resolver?pii=nu7115480 DB - PRIME DP - Unbound Medicine ER -