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Fat Quality Influences the Obesogenic Effect of High Fat Diets.

Abstract

High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.

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  • Authors+Show Affiliations

    ,

    Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. rcrescen@unina.it.

    ,

    Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. francibianco@yahoo.it.

    ,

    Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. arimazzoli@hotmail.it.

    ,

    Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. antonia.giacco@hotmail.it.

    ,

    Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. cancelliererosa@gmail.com.

    ,

    Department of Chemical Sciences, Federico II University, Via Cinthia, 80138 Naples, Italy. difabio@unina.it.

    ,

    Department of Chemical Sciences, Federico II University, Via Cinthia, 80138 Naples, Italy. zarrelli@unina.it. Inter-University Consortium SannioTech, Piazza San G. Moscati, 82030 Apollosa (BN), Italy. zarrelli@unina.it.

    ,

    Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. liverini@unina.it.

    Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. susiossa@unina.it.

    Source

    Nutrients 7:11 2015 Nov 16 pg 9475-91

    MeSH

    Adipose Tissue, Brown
    Alanine Transaminase
    Animals
    Biomarkers
    Body Composition
    Cholesterol
    Diet, High-Fat
    Dietary Fats
    Energy Metabolism
    Fats
    Fatty Acids
    Fatty Acids, Nonesterified
    Fatty Acids, Unsaturated
    Ion Channels
    Linseed Oil
    Lipid Peroxidation
    Liver
    Male
    Mitochondria, Liver
    Mitochondrial Proteins
    Obesity
    Oxidative Stress
    Rats
    Rats, Sprague-Dawley
    Safflower Oil
    Triglycerides
    Uncoupling Protein 1

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26580650

    Citation

    Crescenzo, Raffaella, et al. "Fat Quality Influences the Obesogenic Effect of High Fat Diets." Nutrients, vol. 7, no. 11, 2015, pp. 9475-91.
    Crescenzo R, Bianco F, Mazzoli A, et al. Fat Quality Influences the Obesogenic Effect of High Fat Diets. Nutrients. 2015;7(11):9475-91.
    Crescenzo, R., Bianco, F., Mazzoli, A., Giacco, A., Cancelliere, R., di Fabio, G., ... Iossa, S. (2015). Fat Quality Influences the Obesogenic Effect of High Fat Diets. Nutrients, 7(11), pp. 9475-91. doi:10.3390/nu7115480.
    Crescenzo R, et al. Fat Quality Influences the Obesogenic Effect of High Fat Diets. Nutrients. 2015 Nov 16;7(11):9475-91. PubMed PMID: 26580650.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fat Quality Influences the Obesogenic Effect of High Fat Diets. AU - Crescenzo,Raffaella, AU - Bianco,Francesca, AU - Mazzoli,Arianna, AU - Giacco,Antonia, AU - Cancelliere,Rosa, AU - di Fabio,Giovanni, AU - Zarrelli,Armando, AU - Liverini,Giovanna, AU - Iossa,Susanna, Y1 - 2015/11/16/ PY - 2015/09/22/received PY - 2015/11/02/revised PY - 2015/11/06/accepted PY - 2015/11/19/entrez PY - 2015/11/19/pubmed PY - 2016/8/31/medline KW - hepatic steatosis KW - high fat diet KW - lipid peroxidation KW - unsaturated fatty acids SP - 9475 EP - 91 JF - Nutrients JO - Nutrients VL - 7 IS - 11 N2 - High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26580650/Fat_Quality_Influences_the_Obesogenic_Effect_of_High_Fat_Diets_ L2 - http://www.mdpi.com/resolver?pii=nu7115480 DB - PRIME DP - Unbound Medicine ER -