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House dust mite-specific IgA2 is associated with protection against eczema in allergic patients.
Allergy 2016; 71(4):563-6A

Abstract

Upon inhalation, house dust mite (HDM) allergens are deposited at the nasal and oral mucosa, where IgA is produced abundantly. IgA subclasses have been linked to protection against respiratory allergy previously. It is currently not known whether and how the human IgA subclasses IgA1 and IgA2 contribute to the clinical status of house dust mite-allergic patients. Saliva and serum samples were collected, and HDM-specific, IgE, IgG4, IgA1 and IgA2 levels were determined. HDM-specific levels of IgA in serum were similar to levels measured in nonallergic controls, but HDM-specific levels of IgA2 in saliva were decreased in allergic subjects. HDM-allergic patients who suffered from rhinitis and eczema showed a significant decrease in IgA2-levels compared to patients who suffered from rhinitis only. Taken together, our findings indicate that HDM-specific IgA2, but not IgA1, levels in serum and saliva are reduced in HDM-allergic patients suffering from eczema.

Authors+Show Affiliations

Cell Biology & Immunology Group, Wageningen University, Wageningen, The Netherlands.Cell Biology & Immunology Group, Wageningen University, Wageningen, The Netherlands. FrieslandCampina, Amersfoort, The Netherlands.HAL Allergy, Leiden, The Netherlands.Department of Otorhinolaryngology, Radboud University Medical Centre, Nijmegen, The Netherlands.Cell Biology & Immunology Group, Wageningen University, Wageningen, The Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26582722

Citation

den Hartog, G, et al. "House Dust Mite-specific IgA2 Is Associated With Protection Against Eczema in Allergic Patients." Allergy, vol. 71, no. 4, 2016, pp. 563-6.
den Hartog G, van Neerven RJ, Boot JD, et al. House dust mite-specific IgA2 is associated with protection against eczema in allergic patients. Allergy. 2016;71(4):563-6.
den Hartog, G., van Neerven, R. J., Boot, J. D., Jansen, A. P., & Savelkoul, H. F. (2016). House dust mite-specific IgA2 is associated with protection against eczema in allergic patients. Allergy, 71(4), pp. 563-6. doi:10.1111/all.12807.
den Hartog G, et al. House Dust Mite-specific IgA2 Is Associated With Protection Against Eczema in Allergic Patients. Allergy. 2016;71(4):563-6. PubMed PMID: 26582722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - House dust mite-specific IgA2 is associated with protection against eczema in allergic patients. AU - den Hartog,G, AU - van Neerven,R J J, AU - Boot,J D, AU - Jansen,A P H, AU - Savelkoul,H F J, Y1 - 2016/01/18/ PY - 2015/11/12/accepted PY - 2015/11/20/entrez PY - 2015/11/20/pubmed PY - 2016/12/15/medline KW - IgA KW - eczema KW - house dust mite allergy KW - saliva KW - serum SP - 563 EP - 6 JF - Allergy JO - Allergy VL - 71 IS - 4 N2 - Upon inhalation, house dust mite (HDM) allergens are deposited at the nasal and oral mucosa, where IgA is produced abundantly. IgA subclasses have been linked to protection against respiratory allergy previously. It is currently not known whether and how the human IgA subclasses IgA1 and IgA2 contribute to the clinical status of house dust mite-allergic patients. Saliva and serum samples were collected, and HDM-specific, IgE, IgG4, IgA1 and IgA2 levels were determined. HDM-specific levels of IgA in serum were similar to levels measured in nonallergic controls, but HDM-specific levels of IgA2 in saliva were decreased in allergic subjects. HDM-allergic patients who suffered from rhinitis and eczema showed a significant decrease in IgA2-levels compared to patients who suffered from rhinitis only. Taken together, our findings indicate that HDM-specific IgA2, but not IgA1, levels in serum and saliva are reduced in HDM-allergic patients suffering from eczema. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/26582722/House_dust_mite_specific_IgA2_is_associated_with_protection_against_eczema_in_allergic_patients_ L2 - https://doi.org/10.1111/all.12807 DB - PRIME DP - Unbound Medicine ER -