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Changes in fitness are associated with changes in hippocampal microstructure and hippocampal volume among older adults.

Abstract

This study investigates the effects of fitness changes on hippocampal microstructure and hippocampal volume. Fifty-two healthy participants aged 59-74years with a sedentary lifestyle were randomly assigned to either of two levels of exercise intensity. Training lasted for six months. Physical fitness, hippocampal volumes, and hippocampal microstructure were measured before and after training. Hippocampal microstructure was assessed by mean diffusivity, which inversely reflects tissue density; hence, mean diffusivity is lower for more densely packed tissue. Mean changes in fitness did not differ reliably across intensity levels of training, so data were collapsed across groups. Multivariate modeling of pretest-posttest differences using structural equation modeling (SEM) revealed that individual differences in latent change were reliable for all three constructs. More positive changes in fitness were associated with more positive changes in tissue density (i.e., more negative changes in mean diffusivity), and more positive changes in tissue density were associated with more positive changes in volume. We conclude that fitness-related changes in hippocampal volume may be brought about by changes in tissue density. The relative contributions of angiogenesis, gliogenesis, and/or neurogenesis to changes in tissue density remain to be identified.

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  • Authors+Show Affiliations

    ,

    Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany. Electronic address: kleemeyer@mpib-berlin.mpg.de.

    ,

    Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany; University Clinic Hamburg-Eppendorf, Clinic and Polyclinic for Psychiatry and Psychotherapy, Martinistrasse 52, 20246 Hamburg, Germany. Electronic address: kuehn@mpib-berlin.mpg.de.

    ,

    Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany. Electronic address: prindle@mpib-berlin.mpg.de.

    ,

    Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany. Electronic address: bodammer@mpib-berlin.mpg.de.

    ,

    SMS Medical Institute Berlin/Berliner Akademie für Sportmedizin e.V., Olympiapark Berlin, Hanns-Braun-Straβe/Adlerplatz, 14053 Berlin, Germany. Electronic address: lars.brechtel@medical-institute-berlin.de.

    ,

    German Center for Neurodegenerative Diseases, Fetscherstraβe 105, 01307 Dresden, Germany. Electronic address: alexander.garthe@dzne.de.

    ,

    German Center for Neurodegenerative Diseases, Fetscherstraβe 105, 01307 Dresden, Germany; Center for Regenerative Therapies TU Dresden, Fetscherstraβe 105, 01307 Dresden, Germany. Electronic address: gerd.kempermann@dzne.de.

    ,

    Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany; Leipzig University, Sportwissenschaftliche Fakultät, Jahnallee 59, 04109 Leipzig, Germany. Electronic address: sabine.schaefer@uni-leipzig.de.

    Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany; European University Institute, Via dei Roccettini 9, 50014 San Domenico di Fiesole (FI), Italy. Electronic address: seklindenberger@mpib-berlin.mpg.de.

    Source

    NeuroImage 131: 2016 05 01 pg 155-61

    MeSH

    Aged
    Aging
    Brain Mapping
    Exercise
    Female
    Hippocampus
    Humans
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Neuronal Plasticity
    Organ Size
    Physical Conditioning, Human
    Physical Fitness
    Sedentary Behavior

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    26584869

    Citation

    Kleemeyer, Maike Margarethe, et al. "Changes in Fitness Are Associated With Changes in Hippocampal Microstructure and Hippocampal Volume Among Older Adults." NeuroImage, vol. 131, 2016, pp. 155-61.
    Kleemeyer MM, Kühn S, Prindle J, et al. Changes in fitness are associated with changes in hippocampal microstructure and hippocampal volume among older adults. Neuroimage. 2016;131:155-61.
    Kleemeyer, M. M., Kühn, S., Prindle, J., Bodammer, N. C., Brechtel, L., Garthe, A., ... Lindenberger, U. (2016). Changes in fitness are associated with changes in hippocampal microstructure and hippocampal volume among older adults. NeuroImage, 131, pp. 155-61. doi:10.1016/j.neuroimage.2015.11.026.
    Kleemeyer MM, et al. Changes in Fitness Are Associated With Changes in Hippocampal Microstructure and Hippocampal Volume Among Older Adults. Neuroimage. 2016 05 1;131:155-61. PubMed PMID: 26584869.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Changes in fitness are associated with changes in hippocampal microstructure and hippocampal volume among older adults. AU - Kleemeyer,Maike Margarethe, AU - Kühn,Simone, AU - Prindle,John, AU - Bodammer,Nils Christian, AU - Brechtel,Lars, AU - Garthe,Alexander, AU - Kempermann,Gerd, AU - Schaefer,Sabine, AU - Lindenberger,Ulman, Y1 - 2015/11/14/ PY - 2015/07/01/received PY - 2015/11/05/revised PY - 2015/11/10/accepted PY - 2015/11/21/entrez PY - 2015/11/21/pubmed PY - 2018/1/9/medline KW - Aging KW - Fitness KW - Hippocampal microstructure KW - Hippocampal volume KW - Latent difference modeling KW - Physical exercise SP - 155 EP - 61 JF - NeuroImage JO - Neuroimage VL - 131 N2 - This study investigates the effects of fitness changes on hippocampal microstructure and hippocampal volume. Fifty-two healthy participants aged 59-74years with a sedentary lifestyle were randomly assigned to either of two levels of exercise intensity. Training lasted for six months. Physical fitness, hippocampal volumes, and hippocampal microstructure were measured before and after training. Hippocampal microstructure was assessed by mean diffusivity, which inversely reflects tissue density; hence, mean diffusivity is lower for more densely packed tissue. Mean changes in fitness did not differ reliably across intensity levels of training, so data were collapsed across groups. Multivariate modeling of pretest-posttest differences using structural equation modeling (SEM) revealed that individual differences in latent change were reliable for all three constructs. More positive changes in fitness were associated with more positive changes in tissue density (i.e., more negative changes in mean diffusivity), and more positive changes in tissue density were associated with more positive changes in volume. We conclude that fitness-related changes in hippocampal volume may be brought about by changes in tissue density. The relative contributions of angiogenesis, gliogenesis, and/or neurogenesis to changes in tissue density remain to be identified. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/26584869/Changes_in_fitness_are_associated_with_changes_in_hippocampal_microstructure_and_hippocampal_volume_among_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(15)01048-4 DB - PRIME DP - Unbound Medicine ER -