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Bullous amyloidosis.
Cutis. 1989 Apr; 43(4):346-52.C

Abstract

Amyloidosis may present with involvement of a variety of organ systems. Cutaneous involvement is a relatively common finding in patients with systemic amyloidosis. The occurrence of bullous skin lesions, however, is rare; only a few such cases have been previously reported. We describe a patient who presented with a subepidermal bullous skin disease initially thought to be bullous pemphigoid based on both clinical and histologic appearances. The patient subsequently developed the nephrotic syndrome. Biopsy specimens of the skin and kidney showed involvement of both organs with amyloid, and amyloid was later found in the spleen, heart, and nervous system. No subsequent evidence of myeloma was found in this patient. The clinical, histopathologic, immunofluorescent, and electron microscopic findings of systemic amyloidosis are discussed.

Authors+Show Affiliations

Department of Dermatology, University of Texas Medical School 77030.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

2659287

Citation

Johnson, T M., et al. "Bullous Amyloidosis." Cutis, vol. 43, no. 4, 1989, pp. 346-52.
Johnson TM, Rapini RP, Hebert AA, et al. Bullous amyloidosis. Cutis. 1989;43(4):346-52.
Johnson, T. M., Rapini, R. P., Hebert, A. A., Lowe, L., Verani, R., & Evanoff, G. (1989). Bullous amyloidosis. Cutis, 43(4), 346-52.
Johnson TM, et al. Bullous Amyloidosis. Cutis. 1989;43(4):346-52. PubMed PMID: 2659287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bullous amyloidosis. AU - Johnson,T M, AU - Rapini,R P, AU - Hebert,A A, AU - Lowe,L, AU - Verani,R, AU - Evanoff,G, PY - 1989/4/1/pubmed PY - 1989/4/1/medline PY - 1989/4/1/entrez SP - 346 EP - 52 JF - Cutis JO - Cutis VL - 43 IS - 4 N2 - Amyloidosis may present with involvement of a variety of organ systems. Cutaneous involvement is a relatively common finding in patients with systemic amyloidosis. The occurrence of bullous skin lesions, however, is rare; only a few such cases have been previously reported. We describe a patient who presented with a subepidermal bullous skin disease initially thought to be bullous pemphigoid based on both clinical and histologic appearances. The patient subsequently developed the nephrotic syndrome. Biopsy specimens of the skin and kidney showed involvement of both organs with amyloid, and amyloid was later found in the spleen, heart, and nervous system. No subsequent evidence of myeloma was found in this patient. The clinical, histopathologic, immunofluorescent, and electron microscopic findings of systemic amyloidosis are discussed. SN - 0011-4162 UR - https://www.unboundmedicine.com/medline/citation/2659287/Bullous_amyloidosis_ L2 - http://www.diseaseinfosearch.org/result/380 DB - PRIME DP - Unbound Medicine ER -