Tags

Type your tag names separated by a space and hit enter

Nervous System Lyme Disease.
Clin Lab Med. 2015 Dec; 35(4):779-95.CL

Abstract

Nervous system involvement occurs in 10% to 15% of patients infected with the tick-borne spirochetes Borrelia burgdorferi, B afzelii, and B garinii. Peripheral nervous system involvement is common. Central nervous system (CNS) involvement, most commonly presenting with lymphocytic meningitis, causes modest cerebrospinal fluid (CSF) pleocytosis. Parenchymal CNS infection is rare. If the CNS is invaded, however, measuring local production of anti-B burgdorferi antibodies in the CSF provides a useful marker of infection. Most cases of neuroborreliosis can be cured with oral doxycycline; parenteral regimens should be reserved for patients with particularly severe disease.

Authors+Show Affiliations

Department of Neurosciences, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA; Sidney Kimmel Medical College of Thomas Jefferson University, 132 South, 10th street, Philadelphia, PA 19107, USA. Electronic address: john.halperin@atlantichealth.org.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26593257

Citation

Halperin, John J.. "Nervous System Lyme Disease." Clinics in Laboratory Medicine, vol. 35, no. 4, 2015, pp. 779-95.
Halperin JJ. Nervous System Lyme Disease. Clin Lab Med. 2015;35(4):779-95.
Halperin, J. J. (2015). Nervous System Lyme Disease. Clinics in Laboratory Medicine, 35(4), 779-95. https://doi.org/10.1016/j.cll.2015.07.002
Halperin JJ. Nervous System Lyme Disease. Clin Lab Med. 2015;35(4):779-95. PubMed PMID: 26593257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nervous System Lyme Disease. A1 - Halperin,John J, Y1 - 2015/09/18/ PY - 2015/11/24/entrez PY - 2015/11/26/pubmed PY - 2016/9/22/medline KW - Diagnosis KW - Garin Bujadoux Bannwarth syndrome KW - Lyme disease KW - Nervous system KW - Neuroborreliosis KW - Spinal fluid KW - Treatment SP - 779 EP - 95 JF - Clinics in laboratory medicine JO - Clin. Lab. Med. VL - 35 IS - 4 N2 - Nervous system involvement occurs in 10% to 15% of patients infected with the tick-borne spirochetes Borrelia burgdorferi, B afzelii, and B garinii. Peripheral nervous system involvement is common. Central nervous system (CNS) involvement, most commonly presenting with lymphocytic meningitis, causes modest cerebrospinal fluid (CSF) pleocytosis. Parenchymal CNS infection is rare. If the CNS is invaded, however, measuring local production of anti-B burgdorferi antibodies in the CSF provides a useful marker of infection. Most cases of neuroborreliosis can be cured with oral doxycycline; parenteral regimens should be reserved for patients with particularly severe disease. SN - 1557-9832 UR - https://www.unboundmedicine.com/medline/citation/26593257/Nervous_System_Lyme_Disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-2712(15)00095-5 DB - PRIME DP - Unbound Medicine ER -