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Optimization of Ultrasound-Assisted Extraction of Natural Antioxidants from Sugar Apple (Annona squamosa L.) Peel Using Response Surface Methodology.
Molecules. 2015 Nov 17; 20(11):20448-59.M

Abstract

Sugar apple (Annona squamosa L.) is a popular tropical fruit and its peel is a municipal waste. An ultrasound-assisted extraction method was developed for the recovery of natural antioxidants from sugar apple peel. Central composite design was used to optimize solvent concentration (13.2%-46.8%), ultrasonic time (33.2-66.8 min), and temperature (43.2-76.8 °C) for the recovery of natural antioxidants from sugar apple peel. The second-order polynomial models demonstrated a good fit of the quadratic models with the experimental results in respect to total phenolic content (TPC, R²=0.9524, p<0.0001), FRAP (R²=0.9743, p<0.0001), and TEAC (R²=0.9610, p<0.0001) values. The optimal extraction conditions were 20:1 (mL/g) of solvent-to-solid ratio, 32.68% acetone, and 67.23 °C for 42.54 min under ultrasonic irradiation. Under these conditions, the maximal yield of total phenolic content was 26.81 (mg GA/g FW). The experimental results obtained under optimal conditions agreed well with the predicted results. The application of ultrasound markedly decreased extraction time and improved the extraction efficiency, compared with the conventional methods.

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Authors+Show Affiliations

Deng GF
Department of Clinical Nutrition, Nanshan Hospital, Shenzhen 518052, China. misyfly@163.com.
Xu DP
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. xudongping1989@163.com.
Li S
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. lishasl0308@163.com.
Li HB
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.

MeSH

Analysis of VarianceAnnonaAntioxidantsLiquid-Liquid ExtractionPhenolsPlant ExtractsSolventsTemperatureUltrasonic Waves

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26593890

Citation

Deng, Gui-Fang, et al. "Optimization of Ultrasound-Assisted Extraction of Natural Antioxidants From Sugar Apple (Annona Squamosa L.) Peel Using Response Surface Methodology." Molecules (Basel, Switzerland), vol. 20, no. 11, 2015, pp. 20448-59.
Deng GF, Xu DP, Li S, et al. Optimization of Ultrasound-Assisted Extraction of Natural Antioxidants from Sugar Apple (Annona squamosa L.) Peel Using Response Surface Methodology. Molecules. 2015;20(11):20448-59.
Deng, G. F., Xu, D. P., Li, S., & Li, H. B. (2015). Optimization of Ultrasound-Assisted Extraction of Natural Antioxidants from Sugar Apple (Annona squamosa L.) Peel Using Response Surface Methodology. Molecules (Basel, Switzerland), 20(11), 20448-59. https://doi.org/10.3390/molecules201119708
Deng GF, et al. Optimization of Ultrasound-Assisted Extraction of Natural Antioxidants From Sugar Apple (Annona Squamosa L.) Peel Using Response Surface Methodology. Molecules. 2015 Nov 17;20(11):20448-59. PubMed PMID: 26593890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimization of Ultrasound-Assisted Extraction of Natural Antioxidants from Sugar Apple (Annona squamosa L.) Peel Using Response Surface Methodology. AU - Deng,Gui-Fang, AU - Xu,Dong-Ping, AU - Li,Sha, AU - Li,Hua-Bin, Y1 - 2015/11/17/ PY - 2015/09/30/received PY - 2015/11/04/revised PY - 2015/11/09/accepted PY - 2015/11/24/entrez PY - 2015/11/26/pubmed PY - 2016/9/10/medline KW - antioxidant KW - response surface methodology KW - sugar apple peel KW - ultrasound-assisted extraction SP - 20448 EP - 59 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 20 IS - 11 N2 - Sugar apple (Annona squamosa L.) is a popular tropical fruit and its peel is a municipal waste. An ultrasound-assisted extraction method was developed for the recovery of natural antioxidants from sugar apple peel. Central composite design was used to optimize solvent concentration (13.2%-46.8%), ultrasonic time (33.2-66.8 min), and temperature (43.2-76.8 °C) for the recovery of natural antioxidants from sugar apple peel. The second-order polynomial models demonstrated a good fit of the quadratic models with the experimental results in respect to total phenolic content (TPC, R²=0.9524, p<0.0001), FRAP (R²=0.9743, p<0.0001), and TEAC (R²=0.9610, p<0.0001) values. The optimal extraction conditions were 20:1 (mL/g) of solvent-to-solid ratio, 32.68% acetone, and 67.23 °C for 42.54 min under ultrasonic irradiation. Under these conditions, the maximal yield of total phenolic content was 26.81 (mg GA/g FW). The experimental results obtained under optimal conditions agreed well with the predicted results. The application of ultrasound markedly decreased extraction time and improved the extraction efficiency, compared with the conventional methods. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/26593890/Optimization_of_Ultrasound_Assisted_Extraction_of_Natural_Antioxidants_from_Sugar_Apple__Annona_squamosa_L___Peel_Using_Response_Surface_Methodology_ DB - PRIME DP - Unbound Medicine ER -