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Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies.
Int J Cancer 2016; 138(8):1894-904IJ

Abstract

Results from prospective cohort studies on the association between dietary total fat and fatty acids intake and risk of breast cancer remain controversial. Pertinent prospective cohort studies were identified by a search of Embase and PubMed from inception to September 2015. Study-specific relative risks (RRs) with 95% confidence intervals were pooled using a random-effect model. Between-study heterogeneity and publication bias were assessed, and sensitivity analysis was conducted. Twenty-four independent studies on dietary total fat and fatty acids intake and seven studies on serum fatty acids were included. The pooled RR of breast cancer for the highest vs. lowest category of dietary total fat intake was 1.10 (1.02-1.19); however, no association was observed in studies adjusting for traditional risk factors of breast cancer. No association was observed between animal fat, vegetable fat, saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), n-3 PUFA, n-6 PUFA, eicosapentaenoic acid, docosahexaenoic acid, alpha-linolenic acid, oleic acid, linoleic acid and arachidonic acid and risk of breast cancer. The pooled RRs of breast cancer for the highest vs. lowest category of serum SFA, MUFA, PUFA, n-3 PUFA and n-6 PUFA were 1.00 (0.78-1.28), 1.41 (0.99-2.03), 0.59 (0.27-1.30), 0.81 (0.60-1.10) and 0.84 (0.60-1.18), respectively. Results from this meta-analysis suggested that dietary total fat and fatty acids might be not associated with risk of breast cancer.

Authors+Show Affiliations

Department of Biochemistry, Qingdao University Medical College, Qingdao, China.Department of Biochemistry, Qingdao University Medical College, Qingdao, China.Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26595162

Citation

Cao, Yi, et al. "Dietary Total Fat and Fatty Acids Intake, Serum Fatty Acids and Risk of Breast Cancer: a Meta-analysis of Prospective Cohort Studies." International Journal of Cancer, vol. 138, no. 8, 2016, pp. 1894-904.
Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904.
Cao, Y., Hou, L., & Wang, W. (2016). Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. International Journal of Cancer, 138(8), pp. 1894-904. doi:10.1002/ijc.29938.
Cao Y, Hou L, Wang W. Dietary Total Fat and Fatty Acids Intake, Serum Fatty Acids and Risk of Breast Cancer: a Meta-analysis of Prospective Cohort Studies. Int J Cancer. 2016 Apr 15;138(8):1894-904. PubMed PMID: 26595162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. AU - Cao,Yi, AU - Hou,Lin, AU - Wang,Weijing, Y1 - 2015/12/09/ PY - 2015/09/12/received PY - 2015/10/25/revised PY - 2015/11/18/accepted PY - 2015/11/24/entrez PY - 2015/11/26/pubmed PY - 2016/6/21/medline KW - breast cancer KW - fat KW - fatty acids KW - meta-analysis KW - prospective cohort studies SP - 1894 EP - 904 JF - International journal of cancer JO - Int. J. Cancer VL - 138 IS - 8 N2 - Results from prospective cohort studies on the association between dietary total fat and fatty acids intake and risk of breast cancer remain controversial. Pertinent prospective cohort studies were identified by a search of Embase and PubMed from inception to September 2015. Study-specific relative risks (RRs) with 95% confidence intervals were pooled using a random-effect model. Between-study heterogeneity and publication bias were assessed, and sensitivity analysis was conducted. Twenty-four independent studies on dietary total fat and fatty acids intake and seven studies on serum fatty acids were included. The pooled RR of breast cancer for the highest vs. lowest category of dietary total fat intake was 1.10 (1.02-1.19); however, no association was observed in studies adjusting for traditional risk factors of breast cancer. No association was observed between animal fat, vegetable fat, saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), n-3 PUFA, n-6 PUFA, eicosapentaenoic acid, docosahexaenoic acid, alpha-linolenic acid, oleic acid, linoleic acid and arachidonic acid and risk of breast cancer. The pooled RRs of breast cancer for the highest vs. lowest category of serum SFA, MUFA, PUFA, n-3 PUFA and n-6 PUFA were 1.00 (0.78-1.28), 1.41 (0.99-2.03), 0.59 (0.27-1.30), 0.81 (0.60-1.10) and 0.84 (0.60-1.18), respectively. Results from this meta-analysis suggested that dietary total fat and fatty acids might be not associated with risk of breast cancer. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/26595162/full_citation L2 - https://doi.org/10.1002/ijc.29938 DB - PRIME DP - Unbound Medicine ER -